Venue & Game Details
Kickoff Time: 4:05 PM EDT / 1:05 PM PDT
Venue: SoFi Stadium, Inglewood, California
Capacity: ~70,240 (expandable to 100,000)
Broadcast: FOX: Kevin Kugler, Daryl Johnston, Allison Williams (field reporter)
Injury Report
Indianapolis Colts:
QB Daniel Jones – healthy, 6 total TDs (3 pass, 3 rush), 0 turnovers through 3 games.
RB Jonathan Taylor – healthy, averaging 5.6 ypc, 4 total TDs.
CB Kenny Moore II – doubtful (hamstring).
WR Alec Pierce – questionable (ankle).
CB Jaylon Jones – IR.
Los Angeles Rams:
QB Matthew Stafford – healthy, 5 TDs, 2 INTs through 3 games.
RB Kyren Williams – healthy, averaging 4.8 ypc.
LB Nick Hampton – questionable (shoulder).
G Steve Avila – questionable (knee).
CB Ahkello Witherspoon – IR.
Key Player Matchups
Daniel Jones (IND QB) vs. Rams Pass Rush
Jones has yet to turn the ball over in 2025.
Rams’ front, led by Aaron Donald, will test Indy’s O-line.
Jonathan Taylor (IND RB) vs. Rams Run Defense
Taylor averaging 5.6 ypc, 4 TDs.
Rams rank top-10 in rush defense efficiency.
Matthew Stafford (LAR QB) vs. Colts Secondary
Stafford has 5 TDs in 3 games.
Colts’ defense has 4 INTs and 1 fumble recovery this season.
Michael Pittman Jr. (IND WR) vs. Rams CBs
Pittman is Jones’ top target.
Rams’ secondary is thin with Witherspoon out.
Recent Team Form
Indianapolis Colts (3–0)
W 41–20 vs. Titans (Week 3)
W 27–17 vs. Texans (Week 2)
W 24–17 vs. Jaguars (Week 1)
Strengths: Balanced offense, no turnovers, opportunistic defense.
Weaknesses: Secondary depth, untested against elite teams.
Los Angeles Rams (2–1)
L 26–33 @ Eagles (Week 3)
W 33–19 @ Titans (Week 2)
W 27–20 vs. Cardinals (Week 1)
Strengths: Veteran QB play, strong defensive front.
Weaknesses: Special teams miscues (2 blocked FGs vs. Eagles).
Conference vs. Conference
Colts: AFC South
Rams: NFC West
Cross-conference matchup; no direct playoff tiebreaker impact, but a strong test for both teams.
Series History
All-time series: Rams lead 24–21–2.
Last meeting: Rams beat Colts 27–24 in Indianapolis (Sept. 19, 2021).
Trend: Rams have won 3 of last 4 meetings.
Betting Trends
Indianapolis Colts:
3–0 ATS in 2025.
5–1 ATS in last 6 games.
Over is 5–1 in last 6 games.
Los Angeles Rams:
2–1 ATS in 2025.
5–1 ATS in last 6 games.
Over is 7–0 in last 7 meetings vs. Colts.
Historical Betting Results
2021: Rams -3.5 covered in 27–24 win (Over cashed).
2017: Rams -3 covered in 46–9 win (Over cashed).
2013: Rams +7.5 upset Colts 38–8 (Under cashed).
COLTS NOTES
• COLTS are 3-0 for 1st time since 2009, when they started season 14-0. Rank 2nd in NFL in total offense (418.7 yards/game) & scoring offense (34.3 points/game). • QB DANIEL JONES completed 18 of 25 atts. (72 pct.) for 228 yards & TD vs. 0 INTs with 113.4 rating & had season-high 27 rush yards last week. Is only QB in NFL with 225+ pass yards, TD pass & 0 INTs in each of 1st 3 weeks of season. Aims for 4th in row with 105+ rating. Has rush TD in 4 of his past 5. • RB JONATHAN TAYLOR led team with 118 scrimmage yards (102 rush, 16 rec.) & had 3 rush TDs last week, 3rd-career game with 3+ rush TDs. Aims for 3rd in row with 100+ rush yards & TD. Aims for 3rd in row on road with 2+ rush TDs. Has 1,179 scrimmage yards (147.4 per game) & 11 TDs (9 rush, 2 rec.) over his past 8 games, with 95+ scrimmage yads in each game. Leads NFL with 431 scrimmage yards & 338 rush yards & tied for lead with 4 TDs (3 rush, 1 rec.). • WR MICHAEL PITTMAN led team with 6 catches for 73 yards & TD last week. Has 6 catches, 70+ rec. yards & rec. TD in 2 of 3 games this season. Aims for his 6th in row on road with 5+ catches, 4th in row with 55+ rec. yards & 3rd in row with rec. TD. • WR ALEC PIERCE aims for 3rd in row with 65+ rec. yards. • TE TYLER WARREN ranks 2nd among rookies with 193 rec. yards & tied-2nd with 14 catches this season. • DE KWITY PAYE had 1st sack of season in Week 3. Has TFL in 2 of past 3. • DE TYQUAN LEWIS had career-high 3 TFL with 2 sacks last week, 3rd-career 2-sack game & 1st since 2020. Had TFL in last meeting. • DT DEFOREST BUCKNER aims for 3rd in row with 5+ tackles. • DT NEVILLE GALLIMORE had 1st sack of season in Week 3. • LB ZAIRE FRANKLIN had season-high 7 tackles & PD last week. Aims for 3rd in row with 5+ tackles & PD. Had 12 tackles & half sack in last meeting. • S NICK CROSS had 7 tackles & TFL in Week 3. Has TFL in 3 of past 4. • S CAM BYNUM has INT in 2 of 3 games this season.
RAMS NOTES
• QB MATTHEW STAFFORD had 2 TD passes in Week 3 & has 382 career reg. season TD passes, 9th-most in NFL history. Aims for his 3rd in row with 2+ TD passes. Has 100+ rating in 3 of his past 4 at home. Has 1,586 pass yards (317.2 per game) & 11 TDs vs. 4 INTs for 99.9 rating in 5 career starts vs. Ind., incl. 275+ pass yards in each game. • RB KYREN WILLIAMS had 112 scrimmage yards (94 rush, 18 rec.) & 6th-career rec. TD in Week 3. Has 50+ scrimmage yards in 31 straight games, longest active streak in NFL. Had 127 scrimmage yards (103 rush, 24 rec.) & 2 rush TDs in last meeting. Has 18 TDs (15 rush, 3 rec.) in his past 15 at home, incl. rush TD in each of his past 4 home games. • WR PUKA NACUA had 11 catches for 112 yards last week & became 5th player ever with 10+ catches & 100+ rec. yards in 6 games within 1st 3 career seasons. Leads NFL in receptions (29) & rec. yards (333) in 2025. Has 5+ catches & 50+ rec. yards in 11 straight games. Had 9 catches for 163 yards & rec. TD in last meeting. • WR DAVANTE ADAMS had 56 rec. yards & 105th-career TD catch last week, 10th-most reg. season rec. TDs all-time. Aims for his 3rd in row with rec. TD. Has 100+ rec. yards in 3 of his past 4 vs. Ind. & TD catch in 4 of his 5 career games vs. Ind. • LB BYRON YOUNG had career-high 3 TFL & sack last week, 1 of 4 in NFC with sack in each of 1st 3 weeks. • LB JARED VERSE had 2 TFL, 1st sack of season & 3rd-career FF last week. • LB NATE LANDMAN aims for his 3rd in row with FR. • S QUENTIN LAKE had career-high 4 PD last week. • S KAM CURL led team with 9 tackles last week & ranks tied-3rd among DBs with 26 tackles in 2025. • S JAYLEN MCCOLLOUGH has sack in 2 of 3 games this season.
Game Odds
Indianapolis Colts 49.5
Los Angeles Rams – 3.5
Odds Courtesy of Sports Odd Direct as of Saturday, September 27, 2025
