Venue & Logistics
Venue: Nissan Stadium, Nashville, Tennessee
Kickoff Time: 1:00 PM ET / 12:00 PM CT
Broadcast: CBS: Tom McCarthy, Ross Tucker, Amanda Balionis (field reporter
Weather Forecast (Nashville, TN)
Conditions: Partly sunny, warm
Temperature: ~82°F (28°C) at kickoff, cooling to 75°F (24°C) by the fourth quarter
Winds: 6–10 mph from the southwest
Precipitation: ~20% chance of light showers
Impact: Minimal; excellent football weather
Injury Report
Indianapolis Colts:
QB Daniel Jones (healthy, starting)
RB Jonathan Taylor (ankle soreness) – Probable
WR Tyler Warren (hamstring) – Questionable
CB1 (shoulder) – Out
Tennessee Titans:
QB Cameron Ward (healthy, starting)
RB Tony Pollard (hamstring tightness) – Probable
WR Calvin Ridley (groin) – Questionable
DB1 (concussion protocol) – Out
Key Player Matchups
Daniel Jones (IND) vs. Titans’ Secondary – Jones has 588 yards, 2 TDs, 0 INTs through two games; Tennessee’s DBs must force turnovers.
Jonathan Taylor (IND) vs. Titans’ Run Defense – Taylor rushed for 165 yards in Week 2; Titans rank near the bottom in run defense.
Cameron Ward (TEN) vs. Colts’ Pass Rush – Ward has been sacked 11 times in two games; Indy’s front will look to exploit protection issues.
Calvin Ridley (TEN) vs. Colts’ Corners – If healthy, Ridley is Tennessee’s best chance for explosive plays.
Recent Team Form
Indianapolis Colts (2-0):
W vs. Miami Dolphins 33-0 (Week 1)
W vs. Denver Broncos 29-28 (Week 2)
Offense averaging 31.0 PPG; defense allowing 14.0 PPG.
Tennessee Titans (0-2):
L vs. Los Angeles Rams 33-19 (Week 2)
L vs. Cleveland Browns 24-10 (Week 1)
Offense averaging 14.5 PPG; defense allowing 28.5 PPG.
Series History
All-Time Meetings: Colts lead 37–22
Most Recent: Colts swept Titans in 2024
Trend: Indianapolis has won 5 of the last 6 matchups
Betting Trends
Colts are 4-1 ATS in last 5 games.
Titans are 1-6 ATS in last 7 overall.
The Over has hit in 5 of Indianapolis’ last 7 games.
Colts are 5-1 SU in last 6 vs. Titans.
Historical Betting Results
2024 (Week 13): Colts -2.5, won 27-20 → Cover, Over
2024 (Week 5): Colts -3.5, won 24-17 → Cover, Under
2023 (Week 13): Colts -1.5, won 31-28 (OT) → Cover, Over
COLTS NOTES:
• COLTS are 2-0 for 1st time since 2009. Became 1st team in SB era to not punt in either of 1st 2 games of season. • QB DANIEL JONES passed for 316 yards & had 2 TDs (1 pass, 1 rush) vs. 0 INTs with 107 rating last week, 10th-career 300-yard game. Is only QB in NFL with TD pass, rush TD & 0 INTs in each of 1st 2 weeks of season. Completed 17 of 21 atts. (career-high 81 pct.) for 188 yards & 2 TDs with 115.9 rating in only career start vs. Ten. (9/11/22 w/ NYG). Ranks 2nd in NFL with 588 pass yards in 2025. • RB JONATHAN TAYLOR had 215 scrimmage yards (165 rush, 50 rec.) with 6thcareer TD catch last week, 1st 200-yard game in NFL this season & 5th-career 200-yard game. Has 95+ scrimmage yards in 7 straight games, 2nd-longest active streak in NFL (Bijan Robinson – 8). Rushed for 218 yards & 3 TDs in last meeting. Leads NFL with 313 scrimmage yards & 236 rush yards in 2025. • WR MICHAEL PITTMAN had 4 catches for 40 yards last week. Aims for his 5th in row on road with 5+ catches. Aims for his 3rd in row at Ten. with rec. TD. • WR JOSH DOWNS led team with 6 catches & had 51 rec. yards in Week 2. Aims for his 3rd in row vs. Ten. with 60+ rec. yards & TD catch. • TE TYLER WARREN (rookie) is only TE in NFL with 75+ rec. yards in each of 1st 2 weeks of season & only TE in NFL history with 75+ rec. yards in each of 1st 2 career games. • DT DEFOREST BUCKNER had 6 tackles & team-high 2 TFL last week. Has TFL in 5 of his past 6 on road. Had 5 tackles, TFL & PD in last meeting. • DT GROVER STEWART had 7 tackles & TFL last week. Has TFL in 3 of his past 4. • DE KWITY PAYE has TFL in 4 of his past 5. Had sack in last meeting & has sack in 3 of his past 4 vs. Ten. • LB ZAIRE FRANKLIN had 5 tackles & PD last week. Had 7 tackles in last meeting. • CB KENNY MOORE had TFL last week. Had 2 INTs in last meeting. • S CAM BYNUM is 1 of 2 in NFL (Jordan Battle) with INT in each of 1st 2 weeks of season. • S NICK CROSS had 7 tackles & PD in Week 2. Had PD in last meeting.
TITANS NOTES:
• QB CAM WARD (rookie) passed for 175 yards & 1st-career TD with 0 INTs last week. Is 1st No. 1 overall pick QB ever with 0 INTs in each of 1st 2 career starts. • RB TONY POLLARD rushed for 92 yards last week. Aims for his 3rd in row with 85+ scrimmage yards. Has rush TD in 2 of 3 career games vs. Ind. • WR CALVIN RIDLEY led team with 57 rec. yards last week. Has 55+ rec. yards in 4 of his past 5. Had 78 rec. yards & TD catch in last meeting. Needs 5 catches for 400 career catches. • WR ELIC AYOMANOR (rookie) had 4 catches for 56 yards & 1st-career TD in Week 2. • WR TYLER LOCKETT had 100 rec. yards & 2 TD catches in his last game vs. Ind. (9/12/21 w/ Sea.). Aims for his 3rd in row vs. Ind. with 65+ rec. yards. • TE CHIG OKONKWO had 4 catches last week. Set career highs in catches (9) & rec. yards (81) in last meeting. Has 60+ rec. yards in 2 of his past 3 vs. Ind. • DT JEFFERY SIMMONS tied career high with 9 tackles & had sack in last meeting. Aims for his 3rd in row vs. Ind. with TFL. • LB CODY BARTON had 5 tackles & 6th-career INT last week. Has 5+ tackles in 7 of his past 8. Had 8 tackles in his last game vs. Ind. (12/15/24 w/ Den.). • LB DRE’MONT JONES had TFL last week. Had half sack in his last game vs. Ind. (10/6/22 w/ Den.). • CB JARVIS BROWNLEE aims for 3rd in row with 8+ tackles. Had TFL in last meeting. • CB L’JARIUS SNEED led team with 2 PD last week & aims for his 3rd in row with PD. Had 8 tackles & TFL in last home meeting. • CB ROGER MCCREARY aims for his 3rd in row with 5+ tackles & PD. • S AMANI HOOKER tied for team lead with 8 tackles & had 1st-career sack in Week 2. Aims for his 7th in row with 5+ tackles. Had INT in both games vs. Ind. last season & aims for his 4th in row vs. Ind. with PD. • S XAVIER WOODS had 6 tackles last week.
Game Odds
Indianapolis Colts – 4.5
Tennessee Titans 43.5
Odds Courtesy of Sports Odd Direct as of Saturday, September 20, 2025
