NFL Game Preview: Houston Texans (6-5) vs. Indianapolis Colts (8-3)

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High/Low: 34°F / 23°F

Conditions: Mostly cloudy, breezy

Winds: 17 mph from the northwest

Precipitation: 2–4% chance — cold but dry

Injury Report

Texans:

QB C.J. Stroud (concussion) – Questionable, limited practice

S Jimmie Ward (foot) – OUT

LB Jamal Hill (hamstring) – Questionable

S Jalen Pitre (concussion) – Questionable

CB Ajani Carter (hamstring) – Questionable

Colts:

QB Daniel Jones (leg) – Playing but not 100%

WR Ashton Dulin (hamstring) – Questionable

LB Jaylon Carlies (ankle – IR window) – Eligible but not activated

QB Anthony Richardson (eye – IR) – Eligible but not activated

DT DeForest Buckner – Injured reserve

Team Recent Form

Houston Texans: Winners of 3 straight, 4 of last 5. Defense allows just 16.5 points per game.

Indianapolis Colts: Lost 2 of last 3, including OT loss at Kansas City. Still undefeated at home (6-0).

Player Matchups

QB Battle: Daniel Jones (2,840 yds, 17 TD, 7 INT) vs C.J. Stroud (1,702 yds, 11 TD, 5 INT).

RB Spotlight: Jonathan Taylor leads NFL in rushing yards and TDs; 964 yds, 10 TDs in 8 career games vs Texans.

Defense: Texans rank 2nd in points allowed (16.5/game) vs Colts’ offense averaging 31.0 points/game.

Series History

All-time: Colts lead 33–13–1

Recent: Texans have won 3 straight (2023–2024)

Playoffs: Colts won lone postseason meeting (2018 Wild Card, 21–7)

Betting Trends

ATS Records: Texans 5–6 ATS; Colts 7–3–1 ATS

Totals: Texans UNDER 7–3–1; Colts OVER 6–4

Home/Away Trends: Colts 6–0 at home; Texans 2–3 on road

Bottom Line: This is a classic strength-on-strength matchup: Colts’ explosive offense vs Texans’ stingy defense. With Indianapolis perfect at home and Jonathan Taylor historically dominant against Houston, the Colts are favored. But Houston’s recent surge and defensive resilience make this a dangerous divisional clash.

TEXANS NOTES:

• TEXANS rank 2nd in NFL in points allowed per game (16.5). • QB DAVIS MILLS passed for 153 yards & 2 TDs last week. Aims for 4th in row with TD pass. Has 250+ pass yards in 2 of his past 3. • QB C.J. STROUD aims for his 4th in row on road with 200+ pass yards & TD pass. Has 225+ pass yards & TD in each of his 4 career starts vs. Ind., incl. 2+ TD passes in 3 starts. • RB WOODY MARKS led team with 74 rush yards in Week 12. Aims for 4th in row with 50+ scrimmage yards. Ranks 6th among rookies with 422 rush yards in 2025. • WR CHRISTIAN KIRK had 30th career TD catch last week. Had 4 rec. for 88 yards in his last game vs. Ind. (10/6/24 w/ Jax.). • WR JAYDEN HIGGINS (rookie) had TD catch in Week 12. Ranks tied-5th in rec. TD (4) among rookies this season. • DE WILL ANDERSON JR. led team with season-high 2.5 sacks & had PD last week. Ranks 4th in NFL with 10.5 sacks this season. Has sack in 6 consecutive games, longest active streak. • DE DANIELLE HUNTER had 2 sacks last week & ranks 3rd in the NFL with 11 in sacks this season (11). Has 4 games with 2+ sacks in 2025, tied-most in NFL (Brian Burns & Myles Garrett). Aims for his 3rd in row 1.5+ sacks. • DE TIM SETTLE had 1st sack of season & 2 TFL last week. • DE DEREK BARNETT had sack in Week 12. • LB HENRY TO’OTO’O had 7 tackles & sack in Week 12. Had 7 tackles, TFL & PD in his last game vs. Ind. (9/8/24). • LB AZEEZ AL-SHAAIR had 7 tackles & PD last week. • S CALEN BULLOCK had career-high 2 INTs & FF in Week 12, only player to do so in a single game this season. • S JAYLEN REED led team with 11 tackles & FR last week.

COLTS NOTES:

• QB DANIEL JONES completed 19 of 31 atts. (61.3 pct.) for 181 yards & 2 TDs in Week 12. Is 1 of 3 QBs with 210+ pass yards in 10+ games (10) this season & 1 of 4 with TD pass in 11 games. Has 100+ rating in each of 5 starts at Lucas Oil Stadium this season. Completed 13 of 17 atts. (76.5 pct.) for 197 yards & 2 TDs vs. 0 INTs with 153.3 rating in only career start vs. Hou. (11/13/22 w/ NYG). • RB JONATHAN TAYLOR led team with 66 scrimmage yards (58 rush, 8 rec.) last week. Ranks 2nd NFL in scrimmage yards (1,465), rush yards (1,197) & scrimmage TDs (17) this season. Has 130+ scrimmage yards & TD in 3 of his past 4 at Lucas Oil Stadium in 2025. Has 1,067 scrimmage yards (133.4 per game) and 10 TDs (9 rush, 1 rec.) in 8 career games vs. Hou. • WR MICHAEL PITTMAN had 5 catches for 27 yards & TD in Week 12. Has 5+ catches is 4 of his past 5. Aims for his 4th in row vs. division with 6+ catches & 70+ rec. yards. • WR ALEC PIERCE aims for his 4th in row at Lucas Oil Stadium with 45+ rec. yards. • TE TYLER WARREN had 5 catches for 45 yards last week. Has most receptions (55) & ranks 3rd in rec. yards (662) among rookies in 2025. Has TD catch in 2 of his past 3 at Lucas Oil Stadium. • LB ZAIRE FRANKLIN had 14 tackles, TFL & FF in Week 12. Aims for his 3rd in row with 10+ tackles & TFL. Had 11 tackles & TFL in last meeting. • LB GERMAINE PRATT led team with career-high 20 tackles & had TFL & PD last week. Has TFL in 3 of his past 4. Aims for his 4th in row with PD. • DE LAIATU LATU had 6 tackles, sack & INT in Week 12. Has sack in 4 of his past 5. • DT GROVER STEWART had 1st half sack of season last week. Had 6 tackles & 2 TFL in last meeting. • S CAMRYN BYMUM had 3 tackles in Week 12. Had 6 tackles & INT in only career game vs. Hou. (9/22/24 w/ Min.). • CB SAUCE GARDNER had 7 tackles & PD last week. Aims for his 6th in row with PD.

Game Odds

Houston Texans                44.5

Indianapolis Colts            – 3.5

Odds Courtesy of Sports Odd Direct as of Saturday, November 29, 2025