NFL Game Preview: Denver Broncos (1-1) vs. Los Angeles Chargers (2-0)

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Venue & Logistics

Venue: SoFi Stadium, Inglewood, California

Kickoff Time: 4:05 PM ET / 1:05 PM PT

Broadcast: CBS: Kevin Harlan, Trent Green, Melanie Collins (field reporter)

Weather Forecast (Inglewood, CA)

Conditions: Sunny, warm

Temperature: ~82°F (28°C) at kickoff, cooling to 76°F (24°C) by the fourth quarter

Winds: 6–9 mph from the west

Precipitation:

Impact: Minimal; excellent football weather

Injury Report

Denver Broncos:

QB Bo Nix (rookie, 4 turnovers in 2 games) – Healthy, starting

TE Nate Adkins – Questionable

LB Dre Greenlaw – Questionable

Los Angeles Chargers:

QB Justin Herbert – Healthy, starting

DE Khalil Mack – Questionable

DB Elijah Molden – Questionable

Key Player Matchups

Bo Nix (DEN) vs. Chargers’ Secondary – Nix has shown flashes but also costly turnovers; LA’s defense picked off Geno Smith 3 times in Week 2.

Justin Herbert (LAC) vs. Broncos’ Pass Rush – Herbert has 560 yards, 5 TDs, 0 INTs through two games; Denver must pressure him to have a chance.

Courtland Sutton (DEN) vs. Asante Samuel Jr. (LAC) – Sutton is Nix’s top target; Samuel will be tasked with limiting big plays.

Chargers WR Duo (Allen & Johnston) vs. Broncos’ Secondary – Both scored in Week 2; Denver’s corners must contain them.

Recent Team Form

Denver Broncos (1-1):

W vs. Tennessee Titans 24-17 (Week 1)

L vs. Indianapolis Colts 29-28 (Week 2)

Offense averaging 26.0 PPG; defense allowing 23.0 PPG.

Los Angeles Chargers (2-0):

W vs. Kansas City Chiefs 27-24 (Week 1)

W vs. Las Vegas Raiders 20-9 (Week 2, MNF)

Offense averaging 23.5 PPG; defense allowing 16.5 PPG.

Series History

All-Time Meetings: Broncos lead 73–57–1

Most Recent: Chargers swept Denver in 2024 (34-27 at home, 23-16 in Denver)

Trend: Chargers have won 3 of last 4

Betting Trends

Broncos are 0-2 ATS in 2025

Chargers are 2-0 ATS in 2025

The Over is 1-1 in both teams’ games this season

Broncos are 4-4 ATS as road underdogs with Bo Nix starting

Historical Betting Results

2024 (Week 17): Chargers -7, won 34-27 → No Cover, Over

2024 (Week 6): Chargers -3.5, won 23-16 → Cover, Under

2023 (Week 14): Broncos -2.5, won 24-7 → Cover, Under

BRONCOS NOTES:

• QB BO NIX completed 22 of 30 atts. (73.3 pct.) for 206 yards & 3 TDs vs. INT with 111.2 rating last week, 6th-career game with 3+ TD passes. Has 2+ TD passes in 5 of his past 6. Has 12 TDs vs. 2 INTs with 107.5 rating over past 5 road games. Had 2 TD passes in both games vs. LAC last season. Has 15 TDs (14 pass, 1 rush) vs. INT with 112.2 rating in 6 career games vs. division, with 2+ TD passes in each game. • RB J.K. DOBBINS rushed for 76 yards & TD last week & is 1 of 5 RBs with rush TD in each of 1st 2 weeks of season. Totaled career-high 1,058 scrimmage yards (905 rush, 153 rec.) & had 9 rush TDs in 2024 with LAC. • WR COURTLAND SUTTON has 5+ catches & 50+ rec. yards in 5 of his past 6 on road. Has TD catch in 3 of his past 4 vs. LAC & in 4 of his past 5 vs. division. • WR TROY FRANKLIN led team with career highs in catches (8) & rec. yards (89) & had 3rd-career TD catch in Week 2. Aims for 3rd in row with 4+ catches. • WR MARVIN MIMS had 8th-career rec. TD last week. Aims for his 3rd in row on road with TD catch. Had 62 rec. yards in last meeting. • TE ADAM TRAUTMAN had 10th-career TD catch in Week 2. • LB NIK BONITTO has TFL in 3 of his past 4 vs. LAC & in 8 of past 9 vs. division. • LB JONATHON COOPER aims for his 5th in row with TFL. Has 0.5+ sacks in 2 of his past 3 vs. LAC & in 5 of his past 6 vs. division. • LB JUSTIN STRNAD is 1 of 6 LBs with sack in each of 1st 2 weeks of season. • LB ALEX SINGLETON aims for his 9th in row with 6+ tackles. Has 57 tackles (14.3 per game) over his past 4 games vs. LAC, with 11+ tackles in each game. • DE ZACH ALLEN has 7 TFL in 5 career games vs. LAC. • CB PAT SURTAIN II led team with career-high 11 tackles & had PD last week. Aims for 3rd in row with PD. Has PD in 2 of his past 3 vs. LAC. • CB RILEY MOSS aims for 3rd in row with 5+ tackles & PD. • S TALANOA HUFANGA is only DB in NFL with 10+ tackles in each of 1st 2 weeks of season. Had INT in only career game vs. LAC (11/13/22 w/ SF).

CHARGERS NOTES:

• CHARGERS are 2-0 for 2nd consecutive season & can begin 3-0 for 1st time since 2002. Rank 3rd in NFL in scoring defense (15 points per game allowed). • QB JUSTIN HERBERT completed 19 of 27 atts. (70.4 pct.) for 242 yards & 2 TDs vs. 0 INTs with 122.8 rating & had 31 rush yards last week. Is 1st QB since 2021 with 70+ comp. pct., 2+ TD passes & 0 INTs in each of team’s 1st 2 games of season. Aims 7th in row with 2+ TD passes, 6th in row with 110+ rating & 5th in row with 0 INTs. Aims for 3rd in row vs. Den. with 90+ rating. Has 13 TDs vs. INT with 109.3 rating over past 8 starts vs. division. • RB NAJEE HARRIS had 48 scrimmage yards (28 rush, 20 rec.) last week. Has 216 scrimmage yards (108 per game) & rush TD in 2 career games vs. Den. • WRs KEENAN ALLEN & QUENTIN JOHNSTON are only 2 players in NFL with 60+ rec. yards & TD catch in each of 1st 2 weeks of season. Allen has 6+ catches & 65+ rec. yards in 5 of his past 6 vs. Den. Johnston aims for 4th in row overall with 70+ rec. yards. • WR LADD MCCONKEY has 5+ catches in 9 straight games, 3rd-longest active streak in NFL & longest active streak in AFC. Aims for his 8th in row at SoFi Stadium with 50+ rec. yards. Had 6 catches for 87 yards in last meeting. • LB DAIYAN HENLEY had 10 tackles, 2 PD, sack & 2nd-career INT last week. Aims for 3rd in row with 8+ tackles & sack. Had 10 tackles & TFL in last meeting. • LB TULI TUIPULOTU had 5 tackles, career-high 2 PD & TFL in Week 2. • DT JAMAREE CALDWELL (rookie) had 1st-career sack last week. • CB TARHEEB STILL had career-high 9 tackles with 2 PD & TFL last week. Has 7+ tackles & TFL in 2 of past 3. Had PD in both games vs. Den. last season. • S DERWIN JAMES had 7 tackles & 2 PD in Week 2. Aims for 3rd in row with 7+ tackles & has TFL in 3 of his past 4. Has PD in 4 of his past 5 vs. Den. • S TONY JEFFERSON had 5 tackles, 2 PD & 5th-career INT in season debut last week. Has 5+ tackles in each of 3 career games vs. Den.

Game Odds

Denver Broncos                                45.5

Los Angeles Chargers                     – 2.5

Odds Courtesy of Sports Odd Direct as of Saturday, September 20, 2025