Venue & Game Details
Kickoff: 4:05 PM ET / 2:05 PM MT
Venue: Lucas Oil Stadium, Indianapolis, Indiana
Broadcast: CBS: Kevin Harlan, Trent Green, Melanie Collins (field reporter), streaming via Fubo
Weather Forecast (Indianapolis, IN)
Kickoff Temp: ~78°F (26°C) outside
Conditions: Partly sunny, light southwest wind (5–8 mph)
Impact: None — game played indoors under a retractable roof.
Injury Report
Denver Broncos:
LB Dre Greenlaw — Questionable
TE Nate Adkins — Questionable
TE Evan Engram — Questionable
Indianapolis Colts:
RB Tyler Goodson — Questionable
CB Charvarius Ward — Questionable
CB Jaylon Jones — Questionable
Recent Form
Broncos: W-W-L-W-L — Defense allowing just 14.8 PPG in that span.
Colts: W-L-W-L-L — Offense averaging 21.0 PPG in last 5.
Series History
All-Time: Colts lead 15–14
Last Meeting: 2024 — Broncos won 31-13 in Denver
Trend: Denver has won 2 of the last 3 meetings; Colts have taken 3 of last 4 in Indianapolis.
Key Player Matchups
QB Battle:
Bo Nix (DEN): Rookie QB showed poise in Week 1 despite turnovers; faces a secondary that forced 3 INTs vs. Miami.
Daniel Jones (IND): 272 PASS YDS, 1 TD, plus 2 RUSH TDs in Week 1; must navigate Denver’s elite pass rush.
Skill Positions:
DEN RB Javonte Williams vs. IND run defense — Colts allowed just 78 rush yards in Week 1, but on limited attempts.
IND RB Jonathan Taylor vs. DEN front seven — Taylor’s ability to control tempo could be key against a defense that held Tennessee to 133 total yards.
Defensive Spotlight:
Patrick Surtain II (DEN) vs. Michael Pittman Jr. (IND) — shutdown corner vs. Colts’ top target.
Betting Trends
Broncos are 0-1 ATS in 2025; Bo Nix is 12-7 ATS as a starter (college + NFL).
Colts are 1-0 ATS in 2025.
Under is 1-0 for both teams this season.
Broncos held opponents under 20 points in 6 of last 8 games.
Colts have covered in 4 of last 5 home games as underdogs.
BRONCOS NOTES:
• BRONCOS can begin 2-0 for 1st time since 2021. Led NFL with 6 sacks last week. • QB BO NIX passed for 176 yards & TD last week. Finished 2024 season with 2+ TD passes & 90+ rating in each of his final 4 reg. season starts on road. Passed for 3 TDs in last meeting. • RB J.K. DOBBINS rushed for 63 yards & TD last week in Den. debut. Aims for his 15th in row with 50+ scrimmage yards. • RB RJ HARVEY (rookie) led team with 70 rush yards last week in NFL debut, 2nd-most rush yards by any rookie in Week 1. • WR COURTLAND SUTTON led team with 6 catches for 61 yards & TD last week. Aims for his 4th in row in reg. season with rec. TD. Had TD catch in last meeting & has 70+ rec. yards in 2 of 3 career games vs. Ind. • WR TROY FRANKLIN had 4 catches for 44 yards in Week 1. • TE EVAN ENGRAM had 3 catches last week in Den. debut. Has 5+ catches in each of his 5 career games vs. Ind. Since entering NFL in 2017, ranks 4th among TEs with 499 catches. • TE ADAM TRAUTMAN had TD catch in last meeting. • LB NIK BONITTO had 2 TFL & sack last week. Had 5 tackles, half sack, FF & 50-yard FR-TD in last meeting. Had 5 sacks in 9 road games last season. • LB JONATHON COOPER had sack in Week 1. Aims for 4th in row in reg. season with sack. Had TFL in last meeting. • LB JUSTIN STRNAD had 5 tackles & sack last week. Had 9 tackles & TFL in last meeting. • DE ZACH ALLEN had sack in Week 1. Aims for his 4th in row on road with TFL. • CB PAT SURTAIN II had PD last week. Had 2 PD & INT in last meeting. • CB JA’QUAN MCMILLIAN had sack & FF in Week 1. Had PD in last meeting. • CB RILEY MOSS had 7 tackles & 2 PD last week. • S TALANOA HUFANGA led team with 10 tackles & had 3rd-career FF in Den. debut last week, 3rd-career game with 10+ tackles.
COLTS NOTES:
• COLTS won season-opening game for 1st time since 2013. Became 1st team in at least 47 years (1978) to score on every offensive possession of a game. Can begin season 2-0 for 1st time since 2009. • QB DANIEL JONES completed 22 of 29 atts. (75.9 pct.) for 272 yards & TD vs. 0 INTs with 115.9 rating & rushed for 26 yards & TD last week in Ind. debut. Became 1st QB with 2+ rush TDs, TD pass & 0 INTs in 1st start with team since Jones did so in his 1st start with NYG in 2019. Totaled 294 yards (267 pass, 27 rush) & 2 TDs (1 pass, 1 rush) vs. 0 INTs in only career start vs. Den. (9/12/21 w/ NYG). • RB JONATHAN TAYLOR led team with 98 scrimmage yards (71 rush, 27 rec.) last week, his 6th-straight game with 95+ scrimmage yards. Rushed for 107 yards in last meeting. • RB DJ GIDDENS (rookie) rushed for 41 yards in Week 1 in NFL debut. • WR MICHAEL PITTMAN had 6 catches for team-high 80 rec. yards & TD last week. Has 5+ catches in 7 of his past 8. Has 5+ catches & 55+ rec. yards in each of his 2 career games vs. Den. • TE TYLER WARREN (rookie) had 7 catches for 76 yards last week in NFL debut, tied-3rd most catches by TE in 1st-career game in NFL history. • DE KWITY PAYE had TFL in Week 1, 4th-straight game with TFL. • DE LAIATU LATU had 1st-career INT last week, only INT by DL in NFL in Week 1. • DE SAMSON EBUKAM had sack last week in 1st game since 2023 season. • DT DEFOREST BUCKNER aims for his 3rd in row vs. Den. with sack. • CB KENNY MOORE had sack, FF & PD last week. • S XAVIEN HOWARD had 6th-career FR last week in Ind. debut. Has 7 PD & 3 INTs in 3 career games vs. Den. • S CAM BYNUM had 2 PD & 9th-career INT last week in Ind. debut. Had 8 tackles in only career game vs. Den. (11/19/23 w/ Min.). • S NICK CROSS had 6 tackles & 2nd-career sack in Week 1. Had INT in last meeting.
Game Odds
Denver Broncos – 2.5
Indianapolis Colts 42.5
Odds Courtesy of Sports Odd Direct as of Saturday, September 13, 2025
