Venue & Game Info
Location: Levi’s Stadium, Santa Clara, CA
Kickoff: 8:20 p.m. ET (5:20 p.m. PT)
Broadcast: NBC: Mike Tirico, Cris Collinsworth, Melissa Stark (field reporter)
Westwood One: Ryan Radtke, Marcel Reece
Surface: Natural grass
Note: Levi’s Stadium will also host Super Bowl LX in February 2026
Weather Forecast
Temperature: ~64°F at kickoff
Conditions: Clear skies, 0% chance of rain
Wind: 6 mph NW
Impact: Minimal — perfect conditions for passing and kicking
Injury Report
Falcons
WR Darnell Mooney (hamstring) – Questionable
CB Clark Phillips III (triceps) – Questionable
OT Jake Matthews (ankle) – Questionable
S Billy Bowman Jr. (knee) – Questionable
LB Troy Andersen (knee, PUP) – Out
49ers
LB Fred Warner (ankle) – Out, season-ending
DE Nick Bosa (ACL) – Out, season-ending
TE George Kittle (hamstring) – Questionable, trending toward return
WR Brandon Aiyuk (knee, PUP) – Out
QB Brock Purdy (toe) – Questionable
QB Mac Jones (knee) – Questionable
Player Matchups
Michael Penix Jr. (ATL) vs. 49ers Secondary: Rookie QB Penix (1,168 yds, 4 TD, 3 INT) is coming off a strong MNF win vs. Buffalo.
Bijan Robinson (ATL) vs. 49ers Front Seven: Robinson leads NFL in scrimmage yards (822) and faces a defense missing Warner and Bosa.
Christian McCaffrey (SF) vs. Falcons Run Defense: McCaffrey (447 rush yds, 3 TD; 311 rec yds) remains the centerpiece of SF’s offense.
Drake London (ATL) vs. 49ers CBs: London (269 yds, 1 TD) could exploit a secondary stretched thin by injuries.
49ers QB Situation: Whether it’s Purdy or Mac Jones, protection is a concern — SF has allowed 17 sacks in 6 games.
Team Recent Form
Falcons (3-2): Beat Bills 24-14 in Week 6; offense averaging 378.8 yds/game, defense allowing just 253.4 yds/game (2nd in NFL).
49ers (4-2): Lost 30-19 to Buccaneers; defense has allowed 4.5 YPC over last three games. Still tied atop NFC West.
Series History
All-time: 49ers lead 48–33–1
Last Meeting: Falcons 28, 49ers 14 (Oct. 2022)
Playoffs: Split 1–1 (1998 Falcons win, 2012 49ers win in NFC Championship)
Betting Trends
Falcons are 4-1 to the Under in last 5 games
Falcons are 3-13 SU in last 16 games at San Francisco
49ers are 1-5 ATS in last 6 home games
Over is 4-1 in 49ers’ last 5 games
Projection: Falcons 27, 49ers 24
FALCONS NOTES:
• QB MICHAEL PENIX passed for 250 yards & TD vs. 0 INTs for 97.1 rating in Week 6. Has TD pass in 2 of his 3 career primetime starts. Aims for his 3rd in row with 20+ completions & TD pass. • RB BIJAN ROBINSON had 6 catches, career-high 238 scrimmage yards (career high tying 170 rush, 68 rec) & rush TD in Week 6. Leads NFL with 822 scrimmage yards, most by player in team’s 1st 5 games of season since 2019 (Christian McCaffrey w/ CAR). Is only player with 110+ scrimmage yards in 5 games this season & aims for his 7th in row with 110+ scrimmage yards. Has 95+ scrimmage yards in 10 of his past 11 on road. Has 523 yards (130.8 per game) & 2 rush TDs in 4 career road primetime games. • RB TYLER ALLGEIER has rush TD in 3 of his past 4. • WR DRAKE LONDON had 10 catches for 158 yards & rec. TD in Week 6, his 4thcareer game with 10+ receptions & 150+ rec. yards. Has 5+ catches & 50+ rec. yards in 5 of his past 6. Aims for 3rd in row with 110+ rec. yards & TD catch. • TE KYLE PITTS had rec. TD in last meeting. • LB KADEN ELLIS had 1st FF of season last week. Had 13 tackles in his only career game at SF (11/27/22 w/ NO). • LB DIVINE DEABLO had PD in 4 of his past 5 primetime games & aims for his 4th in row in primetime with PD. Has PD in 4 of 5 games this season. • DL DAVID ONYEMATA had 1st sack of season last week. Aims for his 3rd in row vs. SF with PD. • DL RUKE ORHORHORO had 1st career full sack in Week 6. • CB A.J. TERRELL had 2 PD in 2 of his 3 games this season. Had PD & FR in last meeting. • CB DEE ALFORD had career-high 3 PD, 2nd-career INT & 1st sack of season last week. Aims for his 3rd in row with 5+ tackles. • S XAVIER WATTS (rookie) has 5+ tackles in 4 of his 5 career games.
49ERS NOTES:
• QB BROCK PURDY has TD pass & rush TD in 2 of his past 3 home primetime starts. Has 300+ pass yards in 3 of his past 4 home starts. • QB MAC JONES passed for season-high 347 yards last week. Can become 4th QB in past 5 seasons with 25+ completions & 275+ pass yards in 5 straight games. • RB CHRISTIAN MCCAFFREY had 7 catches, 111 scrimmage yards (57 rec., 54 rush) & 1st rush TD of season in Week 6. Leads all RBs & ranks 2nd in NFL with 46 receptions, tied-most by RB in team’s 1st 6 games of a season all-time. Is 1st RB ever with 50+ rec. yards in each of team’s 1st 6 games of season & 5th RB ever with 5+ catches in each of team’s 1st 6 games of season. Has 46 career games with 50+ rec. yards, tied 4th-most by RB all-time. Is only player with 6 games of 100+ scrimmage yards in 2025 & ranks 2nd in NFL with 780 scrimmage yards in 2025. Aims for his 4th in row with TD. Has 791 scrimmage yards (131.8 per game) & rush TD in 6 career games vs. Atl., incl. 135+ scrimmage yards in each of his past 4 vs. Atl. Has 16 TDs (10 rush, 6 rec.) in 16 career primetime games. • WR KENDRICK BOURNE aims for his 3rd in row with 140+ rec. yards. • TE JAKE TONGES is 1 of 5 NFC TEs with 25+ catches (25) this season. • TE GEORGE KITTLE has 27 catches (9 per game) for 310 yards (103.3 per game) in 3 career games vs. Atl. Has 7 rec. TDs in 7 career home primetime games. • DL MYKEL WILLIAMS (rookie) had 1st-career sack last week. • LB TATUM BETHUNE led team with career-high 10 tackles in Week 6. • LB DEE WINTERS has PD in 3 of his past 4. Aims for his 4th in row at home with 8+ tackles. • CB RENARDO GREEN has 10 PD in his past 8 games. Aims for his 3rd in row with PD. • CB UPTON STOUT (rookie) has 5+ tackles in 4 of his past 5 games. • S MARQUES SIGLE (rookie) had 1st-career TFL last week.
Game Odds
Atlanta Falcons 47.5
San Francisco 49ers – 2.5
Odds Courtesy of Sports Odd Direct as of Saturday, October 18, 2025
