Venue & Game Details
Location: Lumen Field, 800 Occidental Ave S, Seattle, WA 98134
Kickoff: 4:05 PM ET / 1:05 PM PT
Broadcast: CBS: Kevin Harlan, Trent Green, Melanie Collins (field reporter)
Weather Forecast (Seattle)
Conditions: Overcast skies, chance of light rain
Temperature: Low 50s °F at kickoff
Wind: 8–12 mph, swirling winds possible
Factor: Classic “Seattle football weather,” could favor the Seahawks’ physical style
Injury Report
Cardinals:
QB Kyler Murray – OUT (injury)
QB Jacoby Brissett – starting in his place
WR Marvin Harrison Jr. – active, key target
OL depth thin after multiple injuries
Seahawks:
WR Rashid Shaheed – newly acquired at trade deadline, expected to debut
Secondary mostly healthy
OL has allowed just 9 sacks all season, among NFL’s best
Key Player Matchups
Jacoby Brissett (Cardinals QB) vs. Seahawks pass rush – Brissett threw for 261 yards & 2 TDs vs. Dallas, but was sacked 5 times. Seattle has 27 sacks this season.
Marvin Harrison Jr. (Cardinals WR) vs. Tariq Woolen (Seahawks CB) – Harrison is Arizona’s top weapon; Woolen’s length and speed make this a marquee duel.
Sam Darnold (Seahawks QB) vs. Cardinals secondary – Darnold went 16-for-16, 282 yards, 4 TDs in the first half vs. Washington last week. Arizona’s defense has been inconsistent.
Seahawks WR corps (Smith-Njigba, Horton, Shaheed) vs. Cardinals corners – Seattle’s depth at receiver could overwhelm Arizona’s coverage.
Recent Team Form
Cardinals: Snapped a 5-game skid with 27-17 win over Cowboys on MNF. Defense forced 3 turnovers, Brissett efficient.
Seahawks: Dominated Washington 38-14, Darnold threw 4 TDs, offense rolling. Won 6 of last 7.
Series History
All-time: Seahawks lead 30-22-1
Recent: Seahawks have won 8 straight vs. Cardinals
Earlier this season: Seattle won 23-20 in Arizona (Week 4)
Betting Trends
Cardinals: 3-5 ATS; UNDER 5-3 this season
Seahawks: Best ATS record in NFL (6-2); averaging +8.6 points above spread
Head-to-head: Seahawks 8-0 SU last 8 vs. Cardinals
Historical Betting Results
Cardinals games: 62.5% UNDER in 2025
Seahawks games: 62.5% OVER in 2025
Seattle has covered in 6 of 8 games this season
Projected Final Score: Seahawks 28 – Cardinals 17
CARDINALS NOTES:
• QB JACOBY BRISSETT passed for 261 yards & had 3 TDs (2 pass, 1 rush) vs. 0 INTs for 115.1 rating in Week 9, his 4th-career game with both TD pass & rush TD. Has 250+ pass yards & 2+ TD passes in each of his 3 starts in 2025. Aims for his 3rd in row with 110+ rating. Had TD pass vs. 0 INTs in his last start vs. Sea. (9/15/24 w/ NE). • QB KYLER MURRAY aims for his 3rd in row vs. Sea. with 2+ TD passes. Has 20+ completions in 4 of his 5 starts this season. • RB EMARI DEMERCADO rushed for 79 yards last week & has 75+ scrimmage yards in 2 of his past 3. Had TD catch in Week 4 meeting. • RB BAM KNIGHT aims for his 4th in row with 45+ scrimmage yards. • TE TREY MCBRIDE had 5 catches for 55 yards & 5th rec. TD of season last week & became 3rd TE ever (HOFer Tony Gonzalez & Travis Kelce) with 5+ catches in 10 straight games. Aims for his 4th in row with rec. TD. Tied career-high 12 catches and set a career-high 133 yards in last road meeting (11/24/24) & aims for his 4th in row vs. Sea. with 7+ catches. • WR MARVIN HARRISON JR. had career-high 7 catches for 96 yards & 3rd rec. TD of season last week. Has 50+ rec. yards in 4 of his past 5, incl. 6 catches for 66 yards & TD catch in Week 4 meeting. • LB JOSH SWEAT had 2 sacks last week & has 50 career sacks. Is 1 of 3 (Brian Burns & Myles Garrett) with 6+ sacks in each of past 6 seasons. • LB MACK WILSON had 5th-career FF last week. Has TFL & PD in 3 of his past 4 on road. • DL CALAIS CAMPBELL had 2 sacks in Week 9. Is 1 of 4 since 1982 (HOFers Julius Peppers, Bruce Smith & Reggie White) with 5+ sacks in 15+ career seasons (15). • DL WALTER NOLEN (rookie) had 2 TFL, sack & PD in NFL debut last week. • CB WILL JOHNSON (rookie) had 1st-career FF in Week 9. Had 6 PD in 6 career games. • S BUDDA BAKER had 6th-career FR in Week 9. Has 26 straight games with 5+ tackles, 3rd-longest active streak in NFL.
SEAHAWKS NOTES:
• QB SAM DARNOLD completed 21 of 24 atts. (career-high 87.5 pct.) for 330 yards & 4 TDs vs. INT for 141 rating, his 13th-career game with 300+ pass yards & 5th-career game with 4+ TD passes. Since 2024, leads NFL with 18 games with 100+ rating. Leads NFC & ranks 3rd with 116 rating in 2025. Passed for 242 yards & TD with 111.4 rating in Week 4 meeting & aims for his 3rd in row vs. Ari. with 110+ rating. • RB KENNETH WALKER has 634 scrimmage yards (105.7 per game) & 3 rush TDs in 6 career games vs. Ari., with 110+ scrimmage yards in 4 of 6 games. Aims for his 7th in row vs. Ari. with 80+ scrimmage yards. • RB ZACH CHARBONNET aims for his 3rd in row vs. Ari. with rush TD. Has 4 rush TDs in 3 home games in 2025 & aims for his 4th in row at home with rush TD. • WR JAXON SMITH-NJIGBA had 8 catches for 129 yards last week, his 4thstraight game with 8+ catches & 100+ rec. yards. Can become 1st player ever with 8+ catches & 120+ rec. yards in 5 straight games. Leads NFL with 948 rec. yards & 6 games with 100+ rec. yards, tied-most in single season in franchise history. Aims for his 4th in row at home with TD catch, 9th in row at home with 75+ rec. yards & 11th in row at home with 5+ catches. • WR TORY HORTON had 1st-career game with 2 rec. TDs last week & ranks tied-1st among rookies with 5 rec. TDs in 2025. • DE LEONARD WILLIAMS had 4th sack of season last week. Had 1.5 sacks in Week 4 meeting. Aims for his 3rd in row overall & 5th in row vs. Ari. with TFL. • LB DEMARCUS LAWRENCE aims for his 4th in row with 0.5+ sacks. • LB TYRICE KNIGHT had season-high 10 tackles last week, his 4th-career 10+ tackle game. Aims for his 4th in row vs. Ari. with TFL. • LB ERNEST JONES had half sack & INT in Week 4 meeting. • LB DRAKE THOMAS has 6 TFL & 6 PD in his past 5. • CB DEVON WITHERSPOON had 7+ tackles in each of his 3 games in 2025.
Game Odds
Arizona Cardinals 45.5
Seattle Seahawks – 6.5
Odds Courtesy of Sports Odd Direct as of Saturday, November 8, 2025
