The NFC West wraps up the 2025 NFL regular season with a Week 18 matchup pitting the struggling Cardinals against the playoff-bound Rams, who are locked into the postseason but could improve seeding with a win and help from other results. Arizona, amid a rebuild plagued by injuries and offensive woes, aims to play spoiler in this divisional rivalry, while Los Angeles focuses on momentum heading into the playoffs, potentially resting key players if seeding is secured early. The Rams’ high-powered offense, led by Matthew Stafford and new additions like Davante Adams, faces a Cardinals defense ranked near the bottom of the league, setting up a potential blowout at SoFi Stadium.
Venue Location
SoFi Stadium, Inglewood, California. This state-of-the-art domed facility, opened in 2020, seats approximately 70,240 fans for NFL games and features a translucent roof, advanced video boards, and climate control, hosting events like Super Bowl LVI.
Kickoff is scheduled for 4:25 p.m. ET (3:25 p.m. CT / 1:25 p.m. PT / 2:25 p.m. MT).
Broadcast: The game will be broadcast on FOX: Kenny Albert, Jonathan Vilma, Megan Olivi (field reporter
Streaming available via the FOX Sports app or NFL+.
Injury Report
Both teams enter the finale with lengthy lists, but the Cardinals are more severely impacted, particularly on offense, while the Rams manage ailments amid potential rest for starters in a game with limited seeding implications.
Arizona Cardinals Injuries:
WR Marvin Harrison Jr.: Out (foot/heel).
RT Kelvin Beachum: DNP (rest).
LG Evan Brown: DNP (personal).
CB Kitan Crawford: DNP (ankle).
S Jaden Hicks: DNP (knee).
LB Mack Wilson Sr.: DNP (concussion).
S Budda Baker: Limited (concussion/thumb).
RB DeeJay Dallas: Limited (illness).
OT Jonah Williams: Limited (knee).
OT Paris Johnson Jr.: Full (knee).
Total: 9 players on the report, with Harrison’s absence a major blow to the passing game.
Los Angeles Rams Injuries:
WR Davante Adams: Likely out (hamstring).
RB Blake Corum: DNP (ankle).
CB Josh Wallace: DNP (ankle).
G Kevin Dotson: DNP (ankle).
TE Tyler Higbee: Returns to practice (ankle; limited).
S Quentin Lake: Returns to practice Thursday (elbow; limited).
OT Alaric Jackson: Expected to play (knee).
Total: 11 players listed, with 4 DNPs and 6 limited on Wednesday.
Player Matchups
Injuries tilt advantages toward the Rams, particularly if Adams sits, shifting focus to other weapons against Arizona’s porous defense.
Rams QB Matthew Stafford vs. Cardinals Secondary: Stafford exploits a Cardinals unit allowing 238 passing YPG (28th), with targets to Puka Nacua and Cooper Kupp; Arizona’s Crawford (ankle) out weakens coverage.
Cardinals QB Kyler Murray vs. Rams Pass Rush: Murray faces pressure from a Rams front that’s generated 48 sacks, but Dotson’s ankle DNP could open lanes if Jackson plays.
Rams RB Kyren Williams/Blake Corum vs. Cardinals Run Defense: Williams leads the ground attack against Arizona’s 29th-ranked run D (142 YPG allowed); Corum’s ankle DNP may increase Williams’ load.
Cardinals WR Marvin Harrison Jr. (out) vs. Rams CBs: Burden shifts to Trey McBride and others against Lake (elbow, returning), potentially limiting Arizona’s air attack.
Recent Team Forms
The Cardinals have stumbled to a 1-4 mark in their last 5 games, including heavy losses like 45-17 to the Rams and 44-22 to the Seahawks, averaging just 17.2 PPG amid injuries and averaging 303 first downs (31st).
The Rams are 4-1 in their last 5, with wins over strong opponents, averaging 30.1 PPG (1st) and allowing 20.4 PPG, going 10-4 ATS as favorites.
Series History
The Rams lead the all-time series 52-41-2, including 2-0 in playoffs, dating back to 1937. Los Angeles has dominated recently, winning 9 of the last 10 regular-season meetings, including a 45-17 rout of Arizona earlier in 2025. The Cardinals’ last win streak was 8 games from 2014-2017.
Betting Trends
Rams: 11-5 ATS overall; 10-4 ATS as favorites; 15-3 SU in last 18 vs. Cardinals.
Cardinals: 7-9 ATS; 1-6 ATS in last 7; 1-4 ATS on road lately.
Head-to-Head: Rams 4-1 ATS last 5; overs in 6 of last 10.
CARDINALS NOTES:
• QB JACOBY BRISSETT passed for 212 yards & 2 TDs for 91.3 rating in Week 17. Aims for 12th in row with TD pass. Has 200+ pass yards & TD in all 11 starts this season. Ranks 1st with 293 completions, 2nd 3,123 pass yards & tied-3rd with 21 TD passes since Week 6. • RB MICHAEL CARTER has 65+ scrimmage yards in 2 of his past 3. • WR MICHAEL WILSON led team with 89 rec. yards & had TD in Week 17. Aims for 5th in row with TD reception. Had season-high 142 rec. yards & 2 TDs in Week 14 meeting. • TE TREY MCBRIDE had 10 receptions for 76 yards & TD in Week 17, his 36th game with 5+ receptions, most by a TE in 1st 4 seasons in NFL history. Has career-high & franchise-record 119 catches this season, most receptions by a TE in a season in NFL history. Is 1st TE all-time with 110+ receptions in multiple career seasons (111 catches in 2024). • LB JOSH SWEAT ranks tied-2nd with 4 FFs this season & tied-9th with 11 sacks this season. • LB AKEEM DAVIS-GAITHER had 5th PD this season in Week 17. Has 11+ tackles in 2 of his past 3. 1st career season with FF, FR & INT. • LB CODY SIMON (rookie) led team with 15 tackles, tied-2nd most by a rookie in a single game in 2025 & had half sack in Week 17. Aims for 3rd in row with 7+ tackles. • DL CALAIS CAMPBELL had sack in Week 17 & has 117 sacks since 2008, 4thmost in the NFL. Has blocked kick in 2 of his past 3. • CB DENZEL BURKE (rookie) had 6 tackles & 2 PD in Week 17. Has 3 INTs this season, 2nd-most among rookies. • S BUDDA BAKER has 8+ tackles in 5 of his past 6. • S DADRION TAYLOR-DEMERSON had 9 tackles in Week 17 & aims for 3rd in row with 9+ tackles.
RAMS NOTES:
• QB MATTHEW STAFFORD passed for 269 yards & 2 TD in Week 17. Ranks 1st with 42 TD passes & 2nd with 4,448 pass yards in 2025. Has TD pass in 16 straight games this season, tied-longest active streak (Jared Goff). aims for 7th in row at home with 2+ TD passes. Passed for 281 yards & 3 TDs in Week 14 meeting. • RB KYREN WILLIAMS led team with 130 scrimmage yards (92 rush, 38 rec.) in Week 17. Had 84 rush yards & TD in Week 14 meeting. Aims for 6th in row vs. Ari. with TD. • RB BLAKE CORUM had 128 rush yards & TD in Week 14 meeting. Has rush TD in 4 of his past 5 games. • WR PUKA NACUA had 5 receptions for 47 yards & TD in Week 17. Has 303 career receptions & is 5th player in NFL history with 300+ receptions in 1st 3 career seasons. Had 167 rec. yards & 2 TDs in Week 14 meeting. Aims for 3rd in row vs. Ari. with 120+ rec. yards. • TE COLBY PARKINSON aims for 4th in row at home with TD catch. • TE TERRANCE FERGUSON (rookie) had TD catch in Week 17 & aims for 3rd in row with TD catch. • LB NATE LANDMAN had 6 tackles & TFL in Week 17. Aims for 4th in row with TFL. Had INT & 2 PD in Week 14 meeting. • LB BYRON YOUNG had 8 tackles & TFL in Week 17. Had sack in Week 14 meeting & aims for 3rd in row vs. Ari. with sack. • DE KOBIE TURNER has sack in 3 of his past 4. Had sack in Week 14 meeting & aims for 5th in row vs. Ari. with sack. • LB OMAR SPEIGHTS had 8 tackles in Week 17 & aims for 3rd in row with 7+ tackles. • CB EMMANUEL FORBES had PD in Week 17 & aims for 5th in row with PD. Ranks tied-4th with 17 PD this season. • S KAM CURL led team with 9 tackles in Week 17. Has 6+ tackles in 3 of his past 4. Had 6 tackles & sack in Week 14 meeting.
Game Odds
Arizona Cardinals 46.5
Los Angeles Rams – 7.5
Odds Courtesy of Sports Odd Direct as of Saturday, January 3, 2026
