MLB Game Preview: St. Louis Cardinals (55-56) vs. San Diego Padres (61-49)

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San Diego Padres logo

Venue: Petco Park, San Diego, CA
First Pitch: 10:10 PM ET
Broadcast: FOX Sports San Diego, Bally Sports Midwest, MLB.TV

Game Storylines

  • Padres on Fire: San Diego (61–49) has won six straight and sits in the final NL Wild Card spot, just three games behind the Dodgers in the NL West.
  • Cardinals Slumping: St. Louis (55–56) has lost three straight and scored just one run in their last three games.
  • Pitching Matchup: Randy Vasquez (3–4, 3.65 ERA) starts for the Padres, while Michael McGreevy (2–2, 4.91 ERA) takes the mound for the Cardinals.

Pitching Matchup Breakdown

PitcherTeamRecordERAWHIPK/BBNotes
Randy VasquezPadres3–43.651.3752/39Hasn’t gone 5 IP in last 3 starts, but just 4 ER in 13.1 IP
Michael McGreevyCardinals2–24.911.2119/51.4 BB/9 and 5.2 K/9 over 33 IP

Player Spotlight

St. Louis Cardinals

  • Willson Contreras: 15 HR, 62 RBI – leads team in both categories
  • Alec Burleson: .284 AVG – team leader in batting average
  • Masyn Winn: .271 AVG, 23 doubles – solid OBP and speed threat

San Diego Padres

  • Manny Machado: .302 AVG, 20 HR, 71 RBI – 9-game hit streak, batting .452 over last 10 games
  • Luis Arraez: .297 AVG – 14-game hit streak, batting .425 over last 10 games
  • Fernando Tatis Jr.: .267 AVG, 17 HR – 53rd in MLB in home runs

Team Trends & Stats

TeamLast 10 GamesBatting AvgERARun Diff
Padres6–4.2892.93+17
Cardinals3–7.2054.03–18
  • Padres Home Record: 35–18
  • Cardinals Road Record: 23–32
  • Season Series: Tied 2–2 entering Game 5

Game Odds

St. Louis Cardinals           8.5

San Diego Padres             – 149

Odds Courtesy of Sports Odd Direct as of Friday, August 1, 2025