MLB Game Preview: St. Louis Cardinals (30-24) vs. Baltimore Orioles (19-34)

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Baltimore Orioles logo

Game Overview

The Orioles hold a 1-0 series lead after securing a 5-2 victory in Game 1, powered by Dylan Carlson’s three-run homer against his former team. Baltimore is looking to extend its three-game winning streak, while St. Louis aims to bounce back and even the series.

Team Comparisons

CategorySt. Louis CardinalsBaltimore Orioles
Record30-24 (5th in NL)19-34 (9th in AL)
Runs Per Game4.84.2
Home Runs49 (21st in MLB)59 (7th in AL)
Team ERA3.73 (12th in MLB)5.45 (29th in MLB)
WHIP1.219 (11th in MLB)1.483 (4th highest in MLB)

The Cardinals have been stronger on the mound, ranking 12th in team ERA, while the Orioles have struggled with one of the highest ERAs in baseball.

Probable Pitchers

  • St. Louis Cardinals: Andre Pallante (RHP, 4-3, 4.18 ERA, 35 K in 56.2 IP)
  • Baltimore Orioles: Tomoyuki Sugano (RHP, 4-3, 3.07 ERA, 42 K in 58.2 IP)

Pallante has four quality starts this season and is looking for his fourth consecutive outing of five or more innings. Sugano has been Baltimore’s most consistent starter, boasting a 3.07 ERA and solid strikeout numbers.

Key Players to Watch

St. Louis Cardinals

  • Nolan Arenado (3B) – 10 doubles, 5 home runs, .234 batting average.
  • Lars Nootbaar (OF) – Leads the team with 7 home runs, batting .273.
  • Brendan Donovan (INF) – Team-high .328 batting average, 3 home runs.

Baltimore Orioles

  • Cedric Mullins (OF) – 10 home runs, 31 RBIs, leading Baltimore’s offense.
  • Ryan O’Hearn (1B) – Batting .340, carrying a six-game hitting streak.
  • Gunnar Henderson (SS) – 7 home runs, 10 doubles, hitting .266.

Matchup Breakdown

  • Cardinals’ Pitching vs. Orioles’ Offense – St. Louis has a solid pitching staff, while Baltimore has struggled with consistency at the plate.
  • Orioles’ Power vs. Cardinals’ Control – Baltimore ranks 7th in the AL in home runs, while St. Louis has allowed the second-fewest homers in MLB.
  • Bullpen Battle – The Orioles’ bullpen has a 5.52 ERA, ranking 29th in MLB, while the Cardinals’ relievers have been more reliable.

Game Odds

St. Louis Cardinals           – 118

Baltimore Orioles            9

Odds Courtesy of Sports Odds Direct as of Monday, May 26, 2025