MLB Game Preview: San Francisco Giants (71-69) vs. St. Louis Cardinals (70-71)

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St. Louis Cardinals logo

Venue & First Pitch

  • Location: Busch Stadium, St. Louis, Missouri
  • Date: Friday, September 5, 2025
  • Time: 8:15 PM ET
  • Broadcast: NBCS‑BA (SF), Bally Sports Midwest (STL), MLB.TV
  • Capacity: 45,494

Weather Forecast (St. Louis – First Pitch)

  • Conditions: Clear skies, warm evening
  • Temperature: ~82°F (28°C)
  • Wind: SSW at 5–7 mph
  • Precipitation: <5%
  • Impact: Minimal — hitter-friendly temps, light breeze toward LF

Injury Report

Giants

  • No major new injuries; bullpen fully available
  • Several relievers on season-ending IL (various arm injuries)

Cardinals

  • Willson Contreras (suspension) – Out for series
  • Key relievers on IL: Ryan Helsley (elbow), Giovanny Gallegos (shoulder)

Recent Form

Giants (Last 10): 9‑1, +37 run diff — swept Rockies, 10‑8 win in finale (Chapman 2 HR)
Cardinals (Last 10): 6‑4, +8 run diff — took 2 of 3 from Athletics, 5‑1 win in finale

Probable Pitchers

  • SF: RHP Carson Seymour (0‑2, 4.74 ERA, 1.50 WHIP, 6.6 K/9)
    • Last start: 3 IP, 4 ER vs. BAL
    • Road: 0‑0, 4.09 ERA in 11 IP
  • STL: RHP Michael McGreevy (6‑2, 4.17 ERA, 1.19 WHIP, 5.2 K/9)
  • Last start: 6 IP, 1 ER vs. CIN (W)
  • Career vs. SF: 1‑0, 1.13 ERA in 8 IP

Key Player Matchups

  • Matt Chapman (SF) vs. McGreevy
    • 20 HR on season; 4 HR in last 7 games
  • Nolan Gorman (STL) vs. Seymour
    • 14 HR since June 3; 3‑for‑3 with HR in last game
  • LaMonte Wade Jr. (SF) – .380 OBP; table-setter for SF’s middle order
  • Masyn Winn (STL) – .255 AVG, 27 doubles; speed threat

Series History

  • All-Time: STL leads 2,079‑1,992
  • 2024: STL won 5 of 6, outscoring SF 31‑18

Betting Trends

  • Cardinals: 51.6% win rate as favorite; OVER in 5 of last 10
  • Giants: 47.4% win rate as underdog; 4‑1 in last 5 road games
  • Head-to-Head: UNDER in 3 of last 5 meetings

Game Odds

San Francisco Giants      8

St. Louis Cardinals           – 120

Odds Courtesy of Sports Odd Direct as of Thursday, September 4, 2025