MLB Game Preview: San Francisco Giants (44-37) vs. Chicago White Sox (26-55)

Match Details

• Fixture: San Francisco Giants vs Chicago White Sox
• Competition: Major League Baseball – Regular Season
• Date: Friday, June 27, 2025
• First Pitch: 7:40 PM ET
• Venue: Guaranteed Rate Field, Chicago, IL
• Broadcast: NBC Sports Bay Area, NBC Sports Chicago, Fubo (regional restrictions may apply)

Match Significance

This Giants vs White Sox MLB 2025 series opener features two teams on opposite ends of the standings. The Giants are in the thick of the NL Wild Card race, while the White Sox are in full rebuild mode and looking to play spoiler. With both teams sending right-handers to the mound, this game could hinge on early offense and bullpen execution.

San Francisco Giants – Team Overview

• Record: 44-36 (2nd in NL West)
• Last 10 Games: 3-7
• Manager: Bob Melvin
• Probable Starter: Landen Roupp (RHP, 5-5, 3.79 ERA)

Strengths

• Roupp has 7 quality starts in 15 outings and a 1.28 WHIP
• Heliot Ramos (13 HR, .255 AVG) and Casey Schmitt (.295 AVG last 10 games) lead the offense
• Giants are 9-6 when favored by -165 or more

Concerns

• Team batting average of .230 ranks 24th in MLB
• Bullpen has struggled in high-leverage spots
• Just 19-20 on the road this season

Keys to Victory

Roupp must continue his efficient form and limit walks. If Ramos and Schmitt can generate early offense, San Francisco’s bullpen can protect a lead against a struggling White Sox lineup.

Chicago White Sox – Team Overview

• Record: 26-55 (5th in AL Central)
• Last 10 Games: 3-7
• Manager: Pedro Grifol
• Probable Starter: Aaron Civale (RHP, 1-4, 5.03 ERA)

Strengths

• Civale has a 2.01 ERA in 4 career starts vs Giants
• Miguel Vargas leads the team with 10 HR and 20 doubles
• White Sox are 18-10 when out-hitting opponents

Concerns

• Team batting average of .220 ranks 29th in MLB
• 64 home runs (28th in MLB) and .345 slugging percentage (29th)
• Civale has allowed 5+ runs in 3 of his last 5 starts

Keys to Victory

Civale must rediscover his command and keep the ball in the park. If Vargas and Mike Tauchman can spark the offense, Chicago could pull off an upset at home.

Head-to-Head & Betting Insights

• Season Series: First meeting of 2025
• Last Meeting: Giants won 2 of 3 in 2024

Recent Trends

• Giants: 22-14 when recording 8+ hits
• White Sox: 17-23 at home
• Over/Under: Giants games have gone OVER in 36 of 80 contests

Tactical Insight & Prediction

Expect a low-scoring affair early with Roupp and Civale both capable of working deep into games. The Giants’ edge in pitching and lineup depth gives them the upper hand, but if Civale can channel his past success vs San Francisco, the White Sox could keep it close.