MLB Game Preview: San Diego Padres (74-58) vs. Seattle Mariners (71-61)

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MLB Editor
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Seattle Mariners

Game Details

First pitch is scheduled for 9:40 p.m. ET. This marks the fifth meeting of the season, with Seattle leading the series 4–0.

Betting Trends

  • Seattle Mariners: Moneyline –114; Over/Under 7.5 runs
  • San Diego Padres: Moneyline –105; Over/Under 7.5 runs

Seattle is 40–26 at home, while San Diego is 31–36 on the road. The Mariners have gone 51–11 in games they out-hit their opponent, and the Padres’ pitching staff owns a 3.57 ERA, second-best in MLB this season.

Key Storylines

  • San Diego looks to snap a four-game road skid and back-to-back losses, having dropped the first four meetings against Seattle.
  • Seattle aims to reinforce its interleague supremacy at T-Mobile Park after Cal Raleigh clubbed his 50th homer to fuel a 9–6 opener win.
  • Both clubs are jockeying for postseason positioning in their respective divisions, amplifying the significance of each contest down the stretch.

Players to Watch

Seattle Mariners

  • Cal Raleigh, C: Leads MLB with 50 home runs and 19 doubles, anchoring the middle of Seattle’s order.
  • Julio Rodríguez, OF: 11-for-41 with five doubles, a homer and six RBI over his last 10 games, providing a dynamic spark atop the lineup.

San Diego Padres

  • Fernando Tatís Jr., OF: Has compiled 25 doubles, two triples, 18 home runs and 54 RBI, pacing San Diego’s offense.
  • Dylan Cease, RHP: The Padres’ ace has amassed 178 strikeouts over 137.2 innings and continues to miss bats despite a 4.71 ERA.

Pitching Matchup

Castillo and Cease face off in a battle of righty strikeout artists in Seattle, with Castillo sporting a 3.57 ERA and 1.27 WHIP at home, while Cease brings a 4.71 ERA with 178 punchouts this season.

X-Factors

  • Weather: Comfortable upper-70s temperatures and light northwest winds at 5–8 mph should minimize the homerun suppression typically at T-Mobile Park, potentially aiding both offenses.
  • Hit Differential: Seattle is 51–11 when it outhits its opponent, highlighting the importance of a strong offensive showing in this matchup.

Game Odds

San Diego Padres             – 114

Seattle Mariners              7.5

Odds Courtesy of Sports Odds Direct as of Monday, August 25, 2025