MLB Game Preview: San Diego Padres (68-52) vs. San Francisco Giants (59-61)

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San Francisco Giants logo

Venue: Oracle Park, San Francisco, CA
Time: 3:45 PM ET
Broadcast: NBC Sports Bay Area, MLB.tv, ESPN

The San Diego Padres look to complete a three-game sweep of the San Francisco Giants in Wednesday’s matinee at Oracle Park. San Diego has won four straight and leads the season series 6–2, while the Giants have dropped four in a row and continue to slide out of playoff contention.

Pitching Matchup

TeamStarterRecordERAWHIPNotes
PadresNick Pivetta11–42.940.96139 K in 134.2 IP; 9.3 K/9 and elite road splits
GiantsKai-Wei Teng1–15.401.32Rookie making 3rd MLB appearance; 8 K in 8.1 IP
  • Edge: Pivetta – proven veteran with dominant metrics vs. Giants’ rookie

Team Form & Key Stats

San Diego Padres

  • Record: 68–52 (Tied for 1st in NL West)
  • Road Record: 30–32
  • Last 10 Games: 7–3 (.260 AVG, 4.11 ERA, +7 run diff)
  • Strengths:
    • 18–3 when hitting 2+ HR
    • Elite bullpen depth (Jason Adam 8–3, 1.68 ERA)
  • Top Performers:
  • Manny Machado: 29 doubles, 20 HR
  • Xander Bogaerts: 11-for-39, 3 HR, 6 RBI last 10 games
  • Jackson Merrill: HR in Tuesday’s win; .263 AVG

San Francisco Giants

  • Record: 59–61 (3rd in NL West)
  • Home Record: 29–30
  • Last 10 Games: 4–6 (.244 AVG, 4.09 ERA, -2 run diff)
  • Struggles:
    • Lost 12 of last 13 at Oracle Park
    • Scored just 4 runs in last 4 games
  • Top Performers:
  • Casey Schmitt: 4-hit game Tuesday; .254 AVG
  • Rafael Devers: 10-for-36, 4 HR last 10 games
  • Wilmer Flores: 2-for-4, RBI Tuesday

Injury Report

San Diego Padres

  • Out: Jhony Brito (forearm), Joe Musgrove (elbow)

San Francisco Giants

  • Out: Jerar Encarnacion (hamstring), Landen Roupp (elbow), Erik Miller (elbow), Tom Murphy (back)

Betting Insights

  • Trend: 6 of 8 matchups this season have gone Under 9 runs
  • Lean: Padres ML and Under 8.0 – Pivetta’s control + Giants’ offensive slump

Game Odds

San Diego Padres             – 159

San Francisco Giants      8

Odds Courtesy of Sports Odd Direct as of Tuesday, August 12, 2025