MLB Game Preview: San Diego Padres (55-46) vs. Miami Marlins (47-53)

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The San Diego Padres and Miami Marlins face off in the rubber match of their three-game series. First pitch is scheduled for 12:10 PM ET, with both teams looking to gain momentum in the second half of the MLB regular season. After splitting the first two games—San Diego winning 2–1 on Monday and Miami edging out a 4–3 victory Tuesday—this matchup features two high-strikeout starters and playoff implications for the Padres.

Matchup Overview

  • Venue: loanDepot Park, Miami, FL
  • Date: Wednesday, July 23, 2025
  • Time: 12:10 PM ET
  • Broadcast: SDPA (Padres), FDSFL (Marlins)
  • Streaming: MLB.TV, FuboTV (regional restrictions may apply)

Starting Pitchers

TeamPitcherRecordERAWHIPStrikeouts
PadresDylan Cease (RHP)3–94.641.30139
MarlinsSandy Alcantara (RHP)4–97.141.5073
  • Dylan Cease is coming off a dominant 10-strikeout, scoreless outing vs. Washington and ranks 2nd in MLB in K/9 (11.5). He’s allowed just 4 hits in his last start and has six quality starts this season.
  • Sandy Alcantara, the 2022 Cy Young winner, has struggled in 2025 with a 7.14 ERA. He’s allowed 15 earned runs over his last three starts and gave up 6 ER in 4 IP in his last outing vs. San Diego.

Key Players to Watch

San Diego Padres

  • Manny Machado: .285 AVG, 18 HR, 60 RBI – team leader in power and run production.
  • Fernando Tatis Jr.: .265 AVG, 16 HR, 55 BB – dynamic threat with speed and plate discipline.
  • Luis Arraez: .283 AVG – riding a four-game hit streak; .300 over his last five games.
  • Xander Bogaerts: .268 AVG, 21 doubles – hitting .389 over his last five games with 4 RBI.

Miami Marlins

  • Kyle Stowers: .295 AVG, 22 HR, 60 RBI – ranks top 15 in MLB in homers and RBI.
  • Otto Lopez: .251 AVG, 11 HR – 10-for-37 with 8 RBI over his last 10 games.
  • Xavier Edwards: .292 AVG – 16 hits in 18 July games; .333 over his last 10.
  • Agustin Ramirez: .241 AVG, 14 HR – 2 hits and 2 runs scored in Tuesday’s win.

Team Stats & Trends

CategoryPadresMarlins
Batting Average.246 (16th MLB).253 (9th MLB)
Slugging Percentage.375 (25th).391 (19th)
Home Runs86 (27th)91 (26th)
Runs Scored402 (25th)424 (19th)
Team ERA3.61 (5th)4.57 (24th)
  • San Diego is 3–2 vs. Miami this season and has won 4 of its last 5 road games following a loss.
  • Miami has won 5 of its last 10 and is 23–29 at home.

Final Takeaway

The Padres vs. Marlins matchup features two high-upside pitchers trying to rebound and two lineups capable of late-inning fireworks. With Dylan Cease trending upward and Sandy Alcantara fighting inconsistency, San Diego has the edge on the mound. Expect Manny Machado, Kyle Stowers, and Xander Bogaerts to be central figures in what could be a high-scoring finale.

Game Odds

San Diego Padres             – 143

Miami Marlins                  8

Odds Courtesy of Sports Odd Direct as of Tuesday, July 22, 2025