MLB Game Preview: San Diego Padres (27-19) vs. Toronto Blue Jays (23-24)

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Toronto Blue Jays logo

Game Details

  • Matchup: San Diego Padres (27-19) vs. Toronto Blue Jays (23-24)
  • Date: Wednesday, May 21, 2025
  • Time: 7:07 PM ET
  • Venue: Rogers Centre, Toronto, ON
  • TV Broadcast: Sportsnet, Bally Sports San Diego

Team Overview & Recent Performance

San Diego Padres

The Padres are looking to snap a four-game losing streak after struggling offensively in recent matchups. They’ve scored just three total runs over their last four games and have been 0-for-24 with runners in scoring position during that stretch. Despite their struggles, Luis Arraez has been a bright spot, extending his seven-game hitting streak while batting .333 over that span.

San Diego’s pitching has been solid, ranking eighth in MLB with a 3.42 ERA. However, their offense needs to wake up if they want to avoid another loss.

Toronto Blue Jays

The Blue Jays are aiming to clinch the series victory after winning the opener 3-0 on Tuesday. Vladimir Guerrero Jr. and Anthony Santander provided the offense with home runs, while Toronto’s pitching shut down San Diego’s lineup. Guerrero Jr. has been on a 20-game on-base streak, the longest active streak in MLB.

Toronto’s .247 team batting average ranks 12th in MLB, and their pitching has been solid, with Kevin Gausman set to take the mound.

Starting Pitchers

San Diego Padres: Randy Vasquez (3-3, 3.45 ERA)

Vasquez has been steady, posting a 1.80 ERA in his lone career start against Toronto. He’ll need to be sharp against a Blue Jays lineup that has been heating up.

Toronto Blue Jays: Kevin Gausman (3-4, 4.59 ERA)

Gausman has had an up-and-down season, but he holds a 2-1 record with a 3.35 ERA in eight career games against San Diego. He’ll look to continue his dominance against the Padres.

Key Matchups

Fernando Tatis Jr. vs. Blue Jays’ Pitching

Tatis Jr. has been San Diego’s most dangerous hitter, but he’ll need to break out of his slump to give the Padres a chance.

Vladimir Guerrero Jr. vs. Padres’ Pitching

Guerrero Jr. has been Toronto’s most consistent hitter, and his on-base streak makes him a key player to watch.

Bullpen Battle

Toronto’s bullpen was dominant in Game 1, while San Diego’s relief pitching has struggled. If the game is close late, the Blue Jays have the edge.

Toronto has the momentum and a clear pitching advantage, making them the favorites to clinch the series. Expect a low-scoring game, with the Blue Jays having the edge.

Game Odds

San Diego Padres             8.5

Toronto Blue Jays             – 162

Odds Courtesy of Sports Odds Direct as of Tuesday, May 20, 2025