The San Diego Padres (16-7) and Detroit Tigers (14-9) are set to face off in the second game of their three-game series on Tuesday, April 22, 2025, at Comerica Park in Detroit. The Tigers secured a 6-4 victory in the series opener, marking their fourth win in five games.

Game Details
- Date: Tuesday, April 22, 2025
- Time: 6:40 PM ET
- Venue: Comerica Park, Detroit, MI
- TV Broadcast: Bally Sports San Diego, Bally Sports Detroit
- Series Status: Tigers lead 1-0
Team Overview & Key Players
Detroit Tigers (14-9, 2nd in AL Central)
The Tigers have been strong at home, boasting an 8-2 record at Comerica Park. Their offense has been consistent, ranking ninth in the AL with a .387 slugging percentage.
Key Players
- Spencer Torkelson (1B) – Leads the Tigers with seven home runs and 21 RBIs, hitting .288.
- Zach McKinstry (INF) – Went 3-for-4 in Game 1, continuing his hot streak.
- Kerry Carpenter (OF) – Batting .417 over his last 10 games.
- Keider Montero (SP) – Set to start; holds a 0-1 record with a 9.00 ERA, looking to bounce back.
San Diego Padres (16-7, 1st in NL West)
The Padres have been dominant offensively, leading MLB with a .346 team on-base percentage. However, they struggled in Game 1, managing just seven hits.
Key Players
- Fernando Tatis Jr. (OF) – Second on the team with eight home runs, looking to spark the offense.
- Luis Arraez (INF) – Batting .256, but dealing with a neck injury.
- Manny Machado (3B) – Provides veteran leadership, hitting .326 over his last 10 games.
- Randy Vasquez (SP) – Set to start; holds a 1-1 record with a 1.74 ERA, aiming to keep Detroit’s bats in check.
Game 2 Pitching Matchup
Pitcher | Team | Record | ERA | Last Start |
---|---|---|---|---|
Keider Montero | Tigers | 0-1 | 9.00 | 5.0 IP, 5 ER vs. Royals |
Randy Vasquez | Padres | 1-1 | 1.74 | 5.0 IP, 1 ER vs. White Sox |
Montero struggled in his season debut, while Vasquez has been solid, allowing just four earned runs in four starts.
Game Outlook & Predictions
- Tigers’ Strategy: Expect Detroit to rely on early offense, using Torkelson and McKinstry to set the tone.
- Padres’ Adjustments: San Diego must capitalize on scoring opportunities and limit strikeouts against Montero.
- X-Factor: Fernando Tatis Jr.’s ability to drive in runs could be the difference-maker.
Game Odds
San Diego Padres 7.5
Detroit Tigers – 115
Odds Courtesy of Sports Odds Direct as of Monday, April 21, 2025