MLB Game Preview: Pittsburgh Pirates (64-81) vs. Baltimore Orioles (67-77)

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Baltimore Orioles logo

Venue & Game Details

  • First Pitch: 6:35 PM ET
  • Venue: Oriole Park at Camden Yards, 333 West Camden Street, Baltimore, MD 21201
  • Broadcast: MASN (Baltimore), SportsNet Pittsburgh, MLB.TV

Weather Forecast (Baltimore, MD)

  • Kickoff Temp: ~78°F (26°C)
  • Conditions: Mostly sunny, light southwest wind (6 mph)
  • Impact: Ideal baseball weather — minimal effect on ball flight or pitching grip.

Injury Report

Baltimore Orioles:

  • C Adley Rutschman — 10-day IL (oblique)
  • C Samuel Basallo — Day-to-day (hand)
  • SP Dean Kremer — Day-to-day (forearm)
  • INF Jordan Westburg — 10-day IL (ankle)
  • RP Felix Bautista — 60-day IL (shoulder)
  • OF Tyler O’Neill — 10-day IL (wrist)
  • SP Grayson Rodriguez — 60-day IL (elbow)
  • Multiple other depth injuries on 15- and 60-day IL

Pittsburgh Pirates:

  • OF Jack Suwinski — 10-day IL (groin)
  • C Endy Rodriguez — 60-day IL (elbow)
  • INF Enmanuel Valdez — 60-day IL (shoulder)
  • RP Justin Lawrence — 60-day IL (elbow)
  • SP Jared Jones — 60-day IL (elbow)

Series History

  • All-Time: Pirates lead 14–6
  • Last Meeting: 2022 — Pirates won 2 of 3 in Pittsburgh
  • Trend: First meeting of 2025 season; interleague play has been rare between these clubs.

Key Player Matchups

  • Pitching Probables:
    • PIT: Mike Burrows (2–4, 4.08 ERA, 1.26 WHIP, 82 K)
    • BAL: Kyle Bradish (0–1, 3.60 ERA, 1.00 WHIP, 15 K)
  • Hot Bats:
  • BAL: Gunnar Henderson — .274 AVG, 16 HR, 61 RBI; Ryan Mountcastle — 12-for-42 last 10 games with 4 doubles, 1 HR.
  • PIT: Oneil Cruz — 17 2B, 2 3B, 19 HR, 56 RBI; Nick Gonzales — 11-for-39 last 10 games with 4 doubles.

Betting Trends

  • Orioles are 7-3 in last 10 games ATS
  • Pirates are 41-25 when not allowing a home run
  • Over is 4-1 in last 5 Orioles home games vs. NL opponents
  • Pirates are 2-8 in last 10 road games vs. AL East

Game Odds

Pittsburgh Pirates            – 156

Baltimore Orioles      7

Odds Courtesy of Sports Odds Direct as of Tuesday, September 9, 2025