MLB Game Preview: Philadelphia Phillies (54-40) vs. San Diego Padres (51-43)

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San Diego Padres logo

Venue: Petco Park, San Diego, CA
First Pitch: 7:35 PM ET
Broadcast: FOX, NBC Sports Philadelphia, Bally Sports San Diego, MLB.tv

Game Overview

The Philadelphia Phillies (54–40) and San Diego Padres (51–43) clash in Game 2 of their three-game series at Petco Park. San Diego took the opener 4–2 behind a clutch eighth-inning homer from Manny Machado, while Philadelphia looks to bounce back after dropping three of their last four games. Saturday’s matchup features a marquee pitching duel between Zack Wheeler and Yu Darvish, two veterans with postseason pedigree and elite strikeout potential.

Starting Pitchers Breakdown

Philadelphia Phillies – Zack Wheeler (9–3, 2.17 ERA)

  • NL Cy Young contender with 148 strikeouts and a 0.84 WHIP
  • Has gone six straight starts with 6+ strikeouts
  • Dominant on the road: no earned runs allowed in last three away starts
  • Career vs Padres: 3–0, 0.76 ERA, including a 10-strikeout gem on June 30

San Diego Padres – Yu Darvish (0–1, 4.91 ERA)

  • Making his second start since returning from injury
  • Struggled in season debut: 3.2 IP, 2 ER vs Arizona
  • Career vs Phillies: 3–1, 2.15 ERA over 8 starts
  • Needs to limit long balls against a power-heavy Phillies lineup

Key Players to Watch

Philadelphia Phillies

  • Kyle Schwarber: 30 HR, 69 RBI — ranks 4th in MLB HR, 9th in RBI
  • Trea Turner: .294 AVG, 111 hits — leads team in batting average
  • Nick Castellanos: .276 AVG, 22 doubles, 11 HR — consistent bat with recent power surge
  • Alec Bohm: .282 AVG, 8 HR — hitting .278 over last five games

San Diego Padres

  • Manny Machado: .291 AVG, 16 HR, 54 RBI — team leader in all categories
  • Fernando Tatis Jr.: 16 HR, 42 RBI — on a four-game hit streak, dynamic threat
  • Luis Arraez: .285 AVG, 17 doubles — elite contact hitter with gap power
  • Gavin Sheets: .269 AVG, 14 HR — emerging slugger with solid OBP
  • Phillies are 25–7 when favored at –167 or shorter
  • Padres are 4–7 as underdogs at +139 or worse
  • Over has hit in 3 of Phillies’ last 10 games, 4 of Padres’ last 10
  • Phillies are 7–3 ATS in their last 10; Padres are 4–6 ATS

Game Odds

Philadelphia Phillies      – 167

San Diego Padres             8

Odds Courtesy of Sports Odd Direct as of Friday, July 11, 2025