MLB Game Preview: New York Yankees (3-0) vs. Seattle Mariners (2-2)

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Seattle Mariners

First Pitch is scheduled for 9:40 PM ET
Venue: T-Mobile Park, Seattle, Washington
TV: YES Network, MLB.TV, Root Sports NW | Radio: WFAN 660 AM / 101.9 FM (NYY), Seattle Sports 710 AM (SEA)

Game Overview

This early-season interleague series opener sends the red-hot visiting New York Yankees (3-0, 2nd in AL East) to T-Mobile Park to face the host Seattle Mariners (2-2, 4th in AL West). The Yankees have stormed out of the gate with a perfect start after sweeping their opening series, while Seattle has shown competitive play but sits .500 after four games. The Mariners host the three-game set, looking to slow down New York’s momentum in what figures to be a classic AL East vs. AL West pitching duel.

Recent Team Forms

Yankees (3-0): New York has looked dominant early, averaging solid run production while posting a strong team ERA and capitalizing on timely hitting. They enter this road series 3-0 straight up with offensive momentum and a deep (though injury-hit) lineup.

Mariners (2-2): Seattle has been competitive with flashes of strong pitching and power but has shown some inconsistency offensively. They’re 2-2 SU at home to begin the year and will rely on their ace to steady the ship in this series opener.

Probable Pitchers & Player Matchups

Yankees: LHP Ryan Weathers (0-0, making Yankees debut; career 4.94 ERA) vs. Mariners: RHP Luis Castillo (0-0, veteran ace with 3.55 career ERA)

Weathers, acquired in the offseason and making his club debut, brings a solid two-pitch mix (primarily fastball/changeup) with ground-ball tendencies but has shown command issues in past samples. He’ll face a Mariners lineup featuring Randy Arozarena (LF), Cole Bliss (2B), Dominic Canzone (RF), and speed/power threats like Julio Rodríguez and Cal Raleigh.

Castillo, Seattle’s longtime ace, relies on elite velocity, a devastating changeup, and slider to generate strikeouts and weak contact. He’ll square off against the Yankees’ star-studded core, including Aaron Judge (RF/DH), Juan Soto (LF), Giancarlo Stanton (DH/OF), and young contributors like Jasson Domínguez.

Key matchup edges: Castillo’s swing-and-miss arsenal and home dominance versus Weathers’ efficiency against Seattle’s patient, high-contact approach; Weathers’ ground-ball profile versus T-Mobile Park’s pitcher-friendly dimensions. Expect a low-scoring, high-strikeout affair.

Injury Report

Yankees

Anthony Volpe (SS): 10-Day IL (left shoulder surgery recovery) – out until early May.

Carlos Rodón (SP): 15-Day IL (left elbow surgery recovery) – out until late April/early May.

Gerrit Cole (SP): 15-Day IL (Tommy John surgery recovery) – out until mid-May.

Clarke Schmidt (SP): 60-Day IL (right elbow/internal brace surgery) – out until late May.
New York’s rotation and infield depth are significantly impacted early, forcing reliance on call-ups and bullpen games if needed.

Mariners

J.P. Crawford (SS): 10-Day IL (right shoulder soreness) – out until early April.

Miles Mastrobuoni (3B/INF): 10-Day IL (right calf strain) – out until early April.

Bryce Miller (SP): 15-Day IL (left oblique inflammation) – out until late April.

Carlos Vargas (RP): 15-Day IL (right lat strain) – out until early April.

Logan Evans (SP): 60-Day IL (arm) – long-term.
Seattle is thin in the infield and rotation but has promoted depth arms to cover short-term absences.

Series History

The Yankees have owned recent head-to-head play, going 5-1 against the Mariners in 2025 and holding a 13-6 edge over the last three seasons. All-time, the clubs remain competitive in interleague action, but New York has performed well on the road in these matchups. This marks the 2026 opener of the three-game series at T-Mobile Park.

Weather Updates

Game-time conditions at T-Mobile Park (retractable roof — status TBD but mild forecast favors open or partially open): ~49–50°F, mostly cloudy, light wind 4–7 mph (NNE), humidity ~54%, precipitation chance ~0–9% (no delays expected). Cool early-season evening weather with neutral park effects — no extreme wind or carry anticipated, favoring pitchers.

Game Odds

New York Yankees           – 115

Seattle Mariners              7.5

Odds Courtesy of Sports Odds Direct as of Sunday, March 29, 2026