MLB Game Preview: Houston Astros (16-15) vs. Chicago White Sox (9-23)

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Game Overview

  • Matchup: Houston Astros vs. Chicago White Sox
  • Date: Sunday, May 4, 2025
  • Location: Guaranteed Rate Field, Chicago, IL
  • Broadcast: Space City Home Network, Chicago Sports Network
  • First Pitch: 2:10 PM ET

Team Breakdown

Houston Astros (16-15, 2nd in AL West)

  • Recent Form: Coming off a 7-4 loss to the Tigers, snapping a three-game win streak
  • Key Strengths: Strong pitching rotation, balanced lineup
  • Key Players:
    • Jeremy Peña – Batting .275, 5 HR, 18 RBI
    • Jose Altuve – Batting .286, 4 HR, 22 RBI
    • Yainer Diaz – Batting .289, 2 HR, 7 RBI in last 10 games
    • Lance McCullers Jr. – Making his first start since the 2022 World Series

Chicago White Sox (9-23, 5th in AL Central)

  • Recent Form: Coming off an 8-0 win against the Brewers, one of their best performances of the season
  • Key Strengths: Home-field advantage, aggressive hitting
  • Key Players:
    • Luis Robert Jr. – Batting .265, 5 HR, 20 RBI
    • Miguel Vargas – Batting .280, 3 HR, 15 RBI
    • Brooks Baldwin – Batting .250, 1 HR, 4 RBI in last 10 games
    • Bryse Wilson – 0-1, 5.00 ERA, 11 K

Pitching Matchup

  • Astros Starter: Lance McCullers Jr. (First start since 2022 World Series)
  • White Sox Starter: Bryse Wilson (0-1, 5.00 ERA, 11 K)

McCullers returns to the mound after 915 days away from MLB action. Wilson has struggled, allowing a 5.00 ERA in his limited starts.

Game Odds

Houston Astros                 – 218

Chicago White Sox          8

Odds Courtesy of Sports Odds Direct as of Saturday, May 3, 2025