The St. Louis Cardinals and Chicago White Sox face off in a straight doubleheader on Thursday, June 19, 2025, at Guaranteed Rate Field in Chicago. After Wednesday’s game was postponed due to rain, both clubs will play two pivotal interleague matchups with postseason implications for St. Louis and pride on the line for a rebuilding White Sox squad.
📍 Game 1 Details
- Time: 2:10 PM ET
- Pitching Matchup:
- Cardinals: Erick Fedde (3–6, 3.65 ERA)
- White Sox: Sean Burke (3–7, 4.71 ERA)
- Broadcast: Bally Sports Midwest, NBC Sports Chicago, MLB.tv
📍 Game 2 Details
- Time: 7:40 PM ET (approx.)
- Pitching Matchup:
- Cardinals: Michael McGreevy (1–1, 3.09 ERA)
- White Sox: Mike Vasil (3–2, 1.99 ERA)
Game 1 Breakdown: Cardinals vs. White Sox
Erick Fedde returns to face his former team after being traded from Chicago to St. Louis in 2024. He’s been solid on the road with a 3.13 ERA and .211 opponent average. The Cardinals offense, led by Brendan Donovan (.323 AVG) and Willson Contreras (9 HR, 45 RBI), will look to jump on Sean Burke, who’s allowed 15 hits and 9 runs in his last 10.2 innings.
Key Trends:
- Cardinals are 5–1 in their last 6 games at Guaranteed Rate Field.
- White Sox have lost 6 straight and are 23–50 overall.
- St. Louis is 40–32 ATS, while Chicago is 43–51 ATS.
Best Bet: Cardinals -1.5. Fedde’s consistency and the White Sox’s offensive struggles make St. Louis the clear favorite in Game 1.
Game 2 Breakdown: Cardinals vs. White Sox
Michael McGreevy makes just his third MLB start, while Mike Vasil has been dominant at home with a 1.65 ERA and .206 opponent average over 27.1 innings. This game could be tighter, with both teams likely leaning on bullpen depth.
Key Players to Watch:
- Nolan Arenado (Cardinals): 8-game hit streak, .286 AVG over last 10 games.
- Miguel Vargas (White Sox): 10 HR, 31 RBI, 6-game hit streak, .270 AVG over last 10.
- Alec Burleson (Cardinals): 3 HR in last 5 road games after rest days.
- Luis Robert Jr. (White Sox): 21 SB, 6 HR, .190 AVG — a wild card on the basepaths.
Best Bet: Under 8.5 total runs. Both starters have shown the ability to limit damage, and the White Sox offense ranks near the bottom in slugging and OBP.
Series & Betting Insights
- Season Series: Cardinals lead 1–0 after a 12–2 win in Game 1.
- Total Trends: The Over has hit in 7 of St. Louis’ last 8 vs. AL teams, but Game 2 leans Under.
- Prop Watch:
- Willson Contreras has recorded an RBI in 7 of his last 8 day games.
- Miguel Vargas has homered in 7 of his last 10 vs. NL Central teams with winning records.
Final Thoughts
The Cardinals are the better team on paper, with a deeper lineup, more reliable pitching, and playoff aspirations. But the White Sox have been sneaky competitive at home, especially in Game 2 scenarios. Expect Game 1 to favor St. Louis, while Game 2 could be a toss-up if Vasil continues his breakout campaign.
