MLB Game Preview: Cleveland Guardians (60-55) vs. Chicago White Sox (42-74)

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Game Context

The Guardians enter tonight riding a four-game win streak and holding second place in the AL Central. The White Sox are buried at the bottom of the division, are looking to salvage pride and play spoiler. Cleveland leads the season series 7–1 and has outscored Chicago by 19 runs over their last 10 games.

Pitching Matchup

TeamStarting Pitcher2025 Stats
GuardiansJoey Cantillo (LHP)2–2, 4.37 ERA, 1.44 WHIP, 72 K
White SoxSean Burke (RHP)4–8, 4.23 ERA, 1.41 WHIP, 100 K

Cantillo’s underlying metrics (3.30 xFIP) suggest he’s been unlucky and could thrive against a weak White Sox lineup. Burke’s 4.89 xFIP points to regression, and he’s projected to allow nearly 3 ER in under 5 innings.

Key Players to Watch

Cleveland Guardians

  • José Ramírez: 23 HR, .520 SLG — elite production and clutch hitting.
  • Kyle Manzardo: 11-for-30 with 2 HR and 6 RBI over last 10 games.
  • Steven Kwan: .271 AVG, 12-for-44 in last 10 — table-setter with elite contact skills.

Chicago White Sox

  • Luis Robert Jr.: .997 OPS over last two weeks — heating up at the plate.
  • Lenyn Sosa: 13-for-34 with 4 HR in last 10 games — breakout potential.
  • Colson Montgomery: 6 HR, .816 OPS in last two weeks — rising star in the lineup.

Team Trends & Stats

CategoryGuardiansWhite Sox
Last 10 Games8–2 (.267 BA, 2.84 ERA)4–6 (.253 BA, 4.90 ERA)
Road/Home Record31–28 (Away)24–33 (Home)
Record When 5+ Runs38–728–7
Season SeriesGuardians lead 7–1White Sox trail 1–7

Injury Report

White Sox: Missing key arms including Miguel Castro, Martin Perez, and Drew Thorpe.
Guardians: Lane Thomas, Will Brennan, and Ben Lively remain sidelined.

Final Take

Cleveland is surging and has dominated this matchup all season. With Cantillo’s deceptive arsenal and the Guardians’ ability to capitalize on weak defense, they’re well-positioned to extend their win streak. Chicago’s offense has improved post-All-Star break, but their pitching depth and fielding remain liabilities.

Game Odds

Cleveland Guardians      – 131

Chicago White Sox          8.5

Odds Courtesy of Sports Odd Direct as of Friday, August 8, 2025