MLB Game Preview: Cincinnati Reds (72-71) vs. San Diego Padres (78-65)

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San Diego Padres logo

Venue & Game Details

  • First Pitch: 9:40 p.m. ET / 6:40 p.m. PT
  • Venue: PETCO Park, San Diego, California
  • Series: Game 1 of a 3-game set

Weather Forecast (San Diego, CA)

  • Conditions: Clear skies
  • Temperature at First Pitch: ~76°F (24°C)
  • Wind: 5–7 mph from the west
  • Impact: Mild, pitcher-friendly conditions; minimal wind effect.

Injury Report

Cincinnati Reds

  • No major new injuries reported; bullpen arms rested after off day.

San Diego Padres

  • Nestor Cortes — 15-Day IL (elbow)
  • Jason Adam — 15-Day IL (quadriceps)
  • Xander Bogaerts — 10-Day IL (foot)
  • Michael King — 15-Day IL (knee)
  • Jhony Brito — 60-Day IL (forearm)
  • Joe Musgrove — 60-Day IL (elbow)

Key Player Matchups

  1. Elly De La Cruz (CIN) vs. Padres’ Bullpen
    • De La Cruz’s speed and power (20+ HR, 40+ SB) can disrupt games; Padres’ relievers must keep him off base.
  2. Fernando Tatis Jr. (SD) vs. Reds’ Starting Pitcher
    • Tatis enters with a 4-game hitting streak and 20 HR; his ability to spark the offense is critical.
  3. Matt McLain (CIN) vs. Padres’ Infield Defense
  • McLain’s recent power surge (3 HR in last 10 games) could test San Diego’s range up the middle.

Team Records & Recent Form

  • Reds: 32–37 on the road; 8th in NL in team ERA (3.94).
  • Padres: 43–25 at home; 5th in NL in OBP (.323).

Series History

  • 2025 Season Series: Padres lead 2–1.
  • Last Meeting: Padres took 2 of 3 in Cincinnati.

Betting Trends

  • Padres are 29–20 this season when favored at -141 or shorter.
  • Reds are 14–20 as underdogs of +119 or longer.
  • Over has hit in 5 of Padres’ last 10 games; Reds 4–6 to the over in that span.

Game Odds

Cincinnati Reds                 7.5

San Diego Padres             – 141

Odds Courtesy of Sports Odds Direct as of Sunday, September 7, 2025