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MLB Game Preview: Chicago White Sox (5-16) vs. Boston Red Sox (12-11)

The Chicago White Sox and Boston Red Sox are set to face off in the final game of their four-game series on Monday, April 21, 2025, at Fenway Park in Boston. The White Sox are looking to build momentum after snapping their six-game losing streak with an 8-4 victory on Sunday, while the Red Sox aim to bounce back and secure the series win.

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Game Details

  • Date: Monday, April 21, 2025
  • Time: 11:10 AM ET
  • Venue: Fenway Park, Boston
  • TV Broadcast: NESN, CHSN
  • Series Status: White Sox lead 2-1

Team Overview & Key Players

Boston Red Sox (11-11 Record, 4th in AL East)

The Red Sox entered this series riding a four-game winning streak, but their momentum was halted in Sunday’s 8-4 loss. Despite the setback, Boston remains a strong offensive team, ranking 11th in batting average (.246) and 12th in slugging percentage (.397).

Key Players

  • Rafael Devers (3B) – Leads the team with six home runs and 18 RBIs.
  • Wilyer Abreu (OF) – Hit a three-run homer in Sunday’s game.
  • Trevor Story (SS) – Batting .321 with five home runs this season.
  • Walker Buehler (SP) – Set to start; holds a 2-1 record with a 5.23 ERA.

Chicago White Sox (6-16 Record, 5th in AL Central)

The White Sox snapped their six-game losing streak with an 8-4 win on Sunday, marking their first road victory of the season. Their offense has struggled, ranking last in MLB in batting average (.194) and total hits (125), but they showed signs of life in their latest outing.

Key Players

  • Andrew Vaughn (1B) – Hit a two-run homer in Sunday’s win.
  • Luis Robert Jr. (OF) – Scored twice and contributed offensively.
  • Edgar Quero (C) – Delivered a go-ahead two-run single in the seventh inning.
  • Jonathan Cannon (SP) – Set to start; holds a 0-2 record with a 4.42 ERA.

Game 3 Recap (April 20, 2025)

The White Sox defeated the Red Sox 8-4, ending their worst road start in franchise history. Key moments included:

  • Matt Thaiss’ two-run homer in the first inning.
  • Wilyer Abreu’s three-run homer for Boston in the first inning.
  • Edgar Quero’s clutch two-run single in the seventh inning.
  • Andrew Vaughn’s two-run homer in the eighth inning to seal the win.

Game 4 Outlook & Predictions

  • Red Sox’s Strategy: Boston will look to capitalize on Chicago’s struggling pitching staff, with Buehler aiming to control the game early.
  • White Sox’s Adjustments: Chicago must continue their offensive momentum and avoid late-inning collapses.
  • X-Factor: Jonathan Cannon’s ability to limit Boston’s power hitters could determine the outcome.

Chicago White Sox                          9

Boston Red Sox                                 – 298

Odds Courtesy of Sports Odds Direct as of Sunday, April 20, 2025

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