MLB Game Preview: Boston Red Sox (72-60) vs. Baltimore Orioles (60-71)

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Baltimore Orioles logo

Game Details

First pitch is set for 6:35 p.m. ET.

Betting Trends

  • Boston has been the favorite 77 times this season and won 45 (58.4%) of those games.
  • Baltimore is 32–36 as an underdog (47.1%) this year.
  • The Sox have a 4–6–0 ATS mark over their past 10 games, with five of those going over 9 runs.
  • The O’s are 6–4–0 ATS in their last 10 and have gone over the total six times in those outings.

Key Storylines

  • This is the 11th meeting of the season between these AL East rivals, with the series tied 5–5 heading into Game 2.
  • Boston owns a 31–35 road record, while Baltimore is 31–34 at home.
  • The Red Sox are 46–12 when scoring five or more runs; the Orioles are 26–17 when hitting at least two homers in a game.

Players to Watch

Boston Red Sox

  • Jarren Duran, OF: Leads the club with a .334 OBP and a .442 slugging percentage, totaling 131 hits this season.
  • Trevor Story, IF: Carries 82 RBI and a .260 average into Camden Yards, adding speed on the basepaths.
  • Alex Bregman, IF: Hitting .305 with 24 doubles, 16 homers and 39 walks on the campaign.

Baltimore Orioles

  • Gunnar Henderson, 3B: Paces Baltimore with 16 home runs, 59 RBI and a .283 batting average.
  • Jackson Holliday, OF: Riding a seven-game hit streak, he’s at .246 with 15 homers and 37 walks.
  • Colton Cowser, OF: Provides pop in the middle of the lineup with 11 homers and a .216 average.

Pitching Matchup

  • Red Sox: Lucas Giolito is 8-2 with a 3.72 ERA, a 1.27 WHIP and 91 strikeouts over 111 1⁄3 innings this season.
  • Orioles: Kyle Bradish seeks his first win, making his debut with Baltimore after recovering from injury.

X-Factors

  • Weather & Wind: Expect warm, sunny conditions in the low-80s with light southwest winds at 7 mph—ideal for both pitchers and sluggers.
  • Bullpen Depth: Boston’s late-inning arms have a 3.36 ERA over their last 10 games; Baltimore’s relievers sit at 3.63 in the same span.
  • Home-Run Impact: An early homer by either side could tilt the tight over/under line.

Game Odds

Boston Red Sox                 – 116

Baltimore Orioles            9

Odds Courtesy of Sports Odds Direct as of Monday, August 25, 2025