MLB Game Preview: Baltimore Orioles (44-55) vs. Cleveland Guardians (49-50)

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Cleveland Guardians logo

Matchup Overview

  • Venue: Progressive Field, Cleveland, OH
  • Date: Tuesday, July 22, 2025
  • Time: 6:40 PM ET
  • Broadcast: MASN2 (Orioles), CLEG (Guardians)
  • Streaming: FuboTV, MLB.TV (regional restrictions may apply)

Starting Pitchers

TeamPitcherRecordERAStrikeouts
OriolesBrandon Young (RHP)0-47.5225
GuardiansJoey Cantillo (LHP)1-04.1754
  • Brandon Young has struggled in his rookie campaign, allowing a .330 opponent batting average and failing to record a quality start in six outings.
  • Joey Cantillo has shown flashes of dominance, striking out 11.9 batters per nine innings and limiting opponents to a .245 average.

Key Players to Watch

Cleveland Guardians

  • José Ramírez: Batting .294 with 20 HR, 55 RBI, and 29 stolen bases. He homered in Monday’s win and continues to be Cleveland’s offensive catalyst.
  • Steven Kwan: Hitting .285 with 20 doubles and 11 stolen bases. Reached base five times in Monday’s game.
  • Bo Naylor & Kyle Manzardo: Both homered in the series opener, showcasing Cleveland’s emerging power.

Baltimore Orioles

  • Gunnar Henderson: Batting .279 with 11 HR, 35 RBI, and 13 stolen bases. He’s hit safely in seven of his last nine games.
  • Ramón Laureano: Drove in four runs Monday, including a two-run homer. He’s heating up at the plate.
  • Ryan O’Hearn & Jackson Holliday: Provide depth and pop in the middle of the lineup.

Team Stats & Trends

StatOriolesGuardians
Record44-5549-50
Batting Average.239 (23rd in MLB).225 (29th in MLB)
Runs Scored407 (23rd)381 (26th)
Home Runs115 (12th)105 (19th)
Slugging Percentage.397 (16th).373 (27th)
OBP.302 (24th).297 (29th)
Team ERA4.96 (27th)3.96 (17th)
  • Cleveland has won 8 of its last 10 games and is surging post-All-Star break.
  • Baltimore has dropped 5 of its last 6 and is struggling to find consistency.

Final Takeaway

The Cleveland Guardians enter Tuesday’s matchup with momentum and a favorable pitching edge. Joey Cantillo has the tools to neutralize Baltimore’s lineup, while José Ramírez and Steven Kwan continue to anchor Cleveland’s offense. The Baltimore Orioles, led by Gunnar Henderson and Ramón Laureano, will need a bounce-back effort from Brandon Young to stay competitive.

Game Odds

Baltimore Orioles            8.5

Cleveland Guardians      – 140

Odds Courtesy of Sports Odd Direct as of Monday, July 21, 2025