MLB Game Preview: Arizona Diamondbacks (44-46) vs. San Diego Padres (48-41)

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San Diego Padres logo

The San Diego Padres host the Arizona Diamondbacks in a crucial divisional battle to open a three-game series at Petco Park. With both teams jockeying for postseason positioning in the NL West, this matchup features a compelling pitching duel between Yu Darvish, making his season debut, and Zac Gallen, who looks to rebound from recent struggles. Arizona enters the series having lost four of its last five, while San Diego is riding momentum after a series win over the Texas Rangers.

Game Details

MatchupArizona Diamondbacks vs San Diego Padres
DateMonday, July 7, 2025
First Pitch9:40 PM ET
VenuePetco Park, San Diego, CA
BroadcastBally Sports Arizona, Bally Sports San Diego, MLB.tv
Season SeriesFirst meeting of 2025

Team Records & Recent Form

TeamRecordLast 5 GamesDivision Rank
San Diego Padres48–413–22nd in NL West
Arizona Diamondbacks44–461–44th in NL West
  • The Padres are 22–11 this season when favored by –133 or more on the moneyline.
  • The Diamondbacks have won 11 of 16 games this season when listed as underdogs of +111 or longer.

Starting Pitching Matchup

San Diego Padres: Yu Darvish (Season Debut)

  • Making his first start of 2025 after recovering from an elbow injury
  • Last pitched on October 12, 2024: 6.2 IP, 2 ER vs. Dodgers
  • 2024 stats: 7–3, 3.31 ERA, 1.07 WHIP in 16 starts
  • Padres will likely monitor his pitch count closely

Arizona Diamondbacks: Zac Gallen (6–9, 5.45 ERA)

  • 104.2 IP, 98 K, 1.42 WHIP
  • Last outing: 7 IP, 1 ER, 6 K vs. Royals
  • Allowed 12 ER in the two starts prior to that
  • Fastball velocity down 1.2 mph from 2024 (now 92.6 mph)

Players to Watch

San Diego Padres

  • Fernando Tatis Jr.: .278 AVG, 18 HR, 17 SB – elite power-speed combo
  • Manny Machado: .292 AVG, 14 HR, 52 RBI – team leader in RBI
  • Luis Arraez: .290 AVG – 6-for-9 in last series vs. Texas
  • Jake Cronenworth: .265 AVG – clutch hitter with walk-off hit last week

Arizona Diamondbacks

  • Christian Walker: 22 HR, 68 RBI – top 10 in MLB in both categories
  • Ketel Marte: .281 AVG, 15 HR – switch-hitting spark plug
  • Alek Thomas: .244 AVG – 90 mph average exit velocity, but just 74.2 mph over last 7 days
  • Corbin Carroll: .258 AVG, 21 SB – dynamic leadoff threat

Injury Report Highlights

San Diego Padres

  • Yu Darvish – activated from 60-day IL (elbow)
  • Joe Musgrove, Michael King, Jhony Brito – 60-day IL
  • Xander Bogaerts – day-to-day (shoulder)
  • Ryan Bergert, Logan Gillaspie – 15-day IL

Arizona Diamondbacks

  • Gabriel Moreno – 10-day IL (hand)
  • Pavin Smith, Ildemaro Vargas – 10-day IL
  • Kendall Graveman, Ryan Thompson – 15-day IL
  • Corbin Burnes, Blake Walston – 60-day IL

Game Odds

Arizona Diamondbacks 8.5

San Diego Padres             – 195

Odds Courtesy of Sports Odd Direct as of Sunday, July 6, 2025