Kickoff: 12:00 PM ET
Venue: Memorial Stadium (“Death Valley”), Clemson, South Carolina
Broadcast: ESPN
Weather Forecast (Clemson, SC)
Temperature: ~81°F (27°C) at kickoff
Conditions: Mostly sunny, light humidity, winds 5–7 mph
Impact: Excellent football weather; no disruptions expected for passing or kicking.
Injury Report
Syracuse Orange (ACC):
QB Steve Angeli (417 yards, 5 TD, 0 INT vs. Colgate) healthy and in rhythm.
RB Will Nixon (66 yards, 1 TD vs. Colgate) available.
WR Darrell Gill Jr. (152 yards, 2 TDs vs. Colgate) healthy.
No major defensive absences reported.
#12 Clemson Tigers (ACC):
QB Cade Klubnik (207 yards, 1 TD, 1 INT vs. Georgia Tech; plus 62 rushing yards, 1 TD) healthy.
RB Adam Randall (80 yards, 1 TD vs. GT) available.
WR Bryant Wesco Jr. (126 yards, 1 TD vs. GT) active.
Defense intact, led by LB Barrett Carter.
Key Player Matchups
QB Steve Angeli (Syracuse) vs. Clemson Secondary
Angeli is coming off a 5-TD performance; Clemson’s DBs must contain his deep ball.
WR Darrell Gill Jr. (Syracuse) vs. Clemson Corners
Gill’s speed and big-play ability will test Clemson’s coverage.
QB Cade Klubnik (Clemson) vs. Syracuse Pass Rush
Klubnik’s dual-threat ability is key; Syracuse must pressure him to force mistakes.
RB Adam Randall (Clemson) vs. Syracuse Front Seven
Randall’s physical running could wear down Syracuse’s defense.
Recent Team Form
Syracuse Orange (2–1)
8/30/25: W 31–14 vs. Temple
9/6/25: L 27–20 @ Ohio
9/13/25: W 66–24 vs. Colgate
Trend: Offense explosive behind Angeli; defense inconsistent.
#12 Clemson Tigers (1–2)
8/30/25: L 27–24 vs. Alabama
9/6/25: W 34–10 vs. Louisiana Tech
9/13/25: L 24–21 vs. Georgia Tech
Trend: Defense solid, but offense struggling with turnovers and inconsistency.
Series History
Clemson leads the all-time series 10–2.
Last 5 meetings: Clemson 5–0 SU.
2024: Clemson defeated Syracuse 31–14 in the Carrier Dome.
Syracuse’s last win came in 2017 (27–24 in the Carrier Dome).
Betting Trends
Clemson:
0–3 ATS in 2025.
Unders hit in all 3 games.
0–1 ATS as a 17.5+ point favorite this season.
Syracuse:
1–2 ATS in 2025.
Overs hit in 2 of 3 games.
Covered in 2 of last 5 vs. Clemson.
Head-to-Head:
Clemson 5–0 SU in last 5 meetings.
Syracuse has kept 3 of last 5 within two scores.
Historical Betting Results
Clemson: Reliable SU at home, but has struggled ATS early in 2025.
Syracuse: Often undervalued as a double-digit underdog; has covered multiple times vs. Clemson in past decade.
ACC Trends: Conference games between these two often trend under, with defenses dictating pace.
Game Odds
Syracuse Orange 55.5
Clemson Tigers – 17.5
Odds Courtesy of Sports Odd Direct as of Friday, September 19, 2025
