Venue & Game Details
Kickoff Time: 12:00 PM ET
Venue: Acrisure Stadium, Pittsburgh, Pennsylvania
Capacity: ~68,400
Broadcast: ESPN2
Weather Forecast (Pittsburgh, PA)
Kickoff Temperature: ~69°F (21°C)
Conditions: Partly cloudy, mild
Wind: 6–9 mph from the northwest
Precipitation: ~15% chance of light showers
Impact: Comfortable fall football weather; no major disruptions expected.
Injury Report
Louisville Cardinals:
QB Miller Moss – healthy, 690 yards, 2 TDs, 2 INTs.
RB Isaac Brown – healthy, 248 yards, 3 TDs.
WR Chris Bell – healthy, 197 yards, 1 TD.
No major injuries reported.
Pittsburgh Panthers:
QB Eli Holstein – healthy, 822 yards, 9 TDs, 3 INTs.
RB Desmond Reid – healthy, 142 yards, 1 TD.
WR Raphael Williams – healthy, 285 yards, 3 TDs.
LB Dylan Hazen – questionable (shoulder).
Key Player Matchups
Miller Moss (UL QB) vs. Pitt Secondary
Moss is completing 66.3% of passes but has 2 INTs.
Pitt allows 202.7 passing ypg (64th nationally).
Eli Holstein (Pitt QB) vs. Louisville Defense
Holstein has 9 TDs in 3 games.
Louisville’s pass defense ranks 4th nationally (114.7 ypg allowed).
Isaac Brown (UL RB) vs. Pitt Front Seven
Brown averaging 8.2 ypc.
Pitt allows just 83.7 rushing ypg (18th nationally).
Raphael Williams (Pitt WR) vs. Louisville Corners
Williams averaging 95 ypg.
Louisville’s secondary has been elite, allowing only 16 ppg.
Recent Team Form
Louisville Cardinals (3–0)
W 40–17 vs. Bowling Green (Week 3)
W 27–14 vs. Georgia Tech (Week 2)
W 52–10 vs. Eastern Kentucky (Week 1)
Strengths: Top-20 defense (244.7 ypg allowed).
Weaknesses: Penalties (70 ypg, 112th nationally).
Pittsburgh Panthers (2–1)
L 24–31 vs. West Virginia (Week 3)
W 45–14 vs. Kent State (Week 2)
W 35–21 vs. Cincinnati (Week 1)
Strengths: Passing offense (315 ypg, 19th nationally).
Weaknesses: Time of possession (129th nationally, 25:38 avg).
Conference vs. Conference
Both are ACC members.
This is an intra-conference matchup with early-season ACC standings implications.
Series History
All-time series: Pittsburgh leads 10–9.
Last meeting: Louisville beat Pitt 38–21 in 2024.
Trend: Louisville has won 2 of the last 3 matchups.
Betting Trends
Louisville Cardinals:
0–3 ATS in 2025.
5–2 ATS in last 7 ACC games.
2 of 3 games have gone Under.
Pittsburgh Panthers:
2–1 ATS in 2025.
4–1 ATS in last 5 home games.
2 of 3 games have gone Over.
Historical Betting Results
2024: Louisville -3 covered in 38–21 win (Over cashed).
2022: Pitt -2.5 covered in 34–17 win (Under cashed).
2015: Pitt +7 covered in 45–34 win (Over cashed).
Game Odds
Louisville Cardinals – 4.5
Pittsburgh Panthers 57.5
Odds Courtesy of Sports Odd Direct as of Friday, September 26, 2025
