Venue, Date & Time
Location: JMA Wireless Dome, Syracuse, New York
Kickoff: 12:00 PM ET
Broadcast: ACC Network
Weather Forecast
Conditions: Dome stadium (climate-controlled), no weather impact
Outside Syracuse: ~72°F, partly cloudy, light winds
Injury Report
Duke Blue Devils
LB Nick Morris Jr. – Out (season)
LB Kendall Johnson – Out
S Terry Moore – Out
Syracuse Orange
QB Steve Angeli – Out (Achilles, season-ending)
QB Rickie Collins – Starting debut
CB Duce Chestnut – Questionable (leg)
Key Player Matchups
QB Darian Mensah (Duke, 1,305 yds, 11 TD, 2 INT) vs. Syracuse Secondary
Mensah ranks 3rd nationally in passing yards; Syracuse ranks 132nd in FBS vs. the pass.
WR Cooper Barkate (Duke, 337 yds, 1 TD) vs. CB Cornell Perry (Syracuse)
Barkate is Mensah’s top target; Perry leads Syracuse’s coverage unit.
RB Anderson Castle (Duke, 193 yds, 3 TD) vs. LB Gary Bryant III (Syracuse, 21 tackles)
Castle adds balance to Duke’s offense; Bryant is key in run support.
QB Rickie Collins (Syracuse, LSU transfer) vs. DE Vincent Anthony Jr. (Duke, 5 sacks)
Collins makes first career start; Anthony is among ACC sack leaders.
RB Yasin Willis (Syracuse, 233 yds, 4 TD) vs. Duke Front Seven
Willis is a bruising runner; Duke allows 150+ rush yards per game.
Recent Team Forms
Duke Blue Devils (2-2, 1-0 ACC)
W 45–33 vs. NC State
L 34–27 @ Tulane
L 45–19 vs. Illinois
W 45–17 vs. Elon
Trend: Explosive offense (34 PPG), but defense allows 32.3 PPG
Syracuse Orange (3-1, 1-0 ACC)
W 34–21 @ Clemson
W 66–24 vs. Colgate
W 27–20 OT vs. UConn
L 45–26 vs. Tennessee
Trend: High-powered passing attack (38.3 PPG), defense allows 27.5 PPG
Conference Context
Both teams: ACC Atlantic Coast rivals
Duke: Looking to build momentum after first ACC win
Syracuse: Riding high after upset at Clemson, but QB change adds uncertainty
Series History
All-time H2H: Duke leads 4–1
Last Meeting: Duke 38–24 (2020)
Syracuse’s lone win: 49–6 in 2019
Trend: Duke 3–0 in Syracuse
Betting Trends
Duke:
1–3 ATS in 2025
4–0 to the Over this season
Syracuse:
2–2 ATS in 2025
3–1 to the Over this season
Historical Betting Results
2020: Duke -2.5 covered, won 38–24 (Over 54.5)
2019: Syracuse +8.5 covered, won 49–6 (Over 52.5)
2014: Duke -3.5 covered, won 27–10 (Under 48)
1939: Duke -14 covered, won 33–6 (Under 40)
1938: Duke -7 covered, won 21–0 (Under 35)
Game Odds
Duke Blue Devils – 4
Syracuse Orange 59.5
Odds Courtesy of Sports Odd Direct as of Friday, September 26, 2025
