Venue & Game Details
Kickoff Time: 3:30 PM ET / 2:30 PM CT
Venue: Vaught-Hemingway Stadium, Oxford, Mississippi
Capacity: ~64,000
Broadcast: ABC
Weather Forecast (Oxford, MS)
Kickoff Temperature: ~82°F (28°C)
Conditions: Partly sunny, humid
Wind: 7–11 mph from the south
Precipitation: ~20% chance of scattered showers
Impact: Warm, sticky conditions typical of late September in the Deep South; stamina and depth could be factors.
Injury Report
LSU Tigers:
QB Garrett Nussmeier – healthy, 960 yards, 6 TDs, 2 INTs.
RB Caden Durham – healthy, 213 yards, 2 TDs.
WR Aaron Anderson – healthy, 293 yards.
CB Zy Alexander – questionable (ankle).
Ole Miss Rebels:
QB Trinidad Chambliss – healthy, 719 yards, 4 TDs, 0 INTs.
RB Kewan Lacy – healthy, 358 yards, 7 TDs.
WR Harrison Wallace III – healthy, 343 yards, 2 TDs.
LB Suntarine Perkins – questionable (shoulder).
Key Player Matchups
Garrett Nussmeier (LSU QB) vs. Ole Miss Secondary
Nussmeier is completing 68.6% of passes.
Rebels’ pass defense ranks 25th nationally but has been vulnerable to chunk plays.
Trinidad Chambliss (Ole Miss QB) vs. LSU Pass Rush
Chambliss has been efficient and mobile, adding 112 rushing yards vs. Tulane.
LSU’s defense ranks 17th in total yards allowed and 9th in scoring defense.
Caden Durham (LSU RB) vs. Rebels Run Defense
Rebels allow 190.5 rushing ypg (121st in FBS).
LSU may lean on Durham to control tempo.
Kewan Lacy (Ole Miss RB) vs. LSU Front Seven
Lacy has 7 rushing TDs in 4 games.
LSU allows just 64 rushing ypg (10th nationally).
Recent Team Form
LSU Tigers (4–0)
W 56–10 vs. Southeastern Louisiana (Week 4)
W 27–17 vs. Florida (Week 3)
W 24–13 vs. Clemson (Week 2)
W 38–7 vs. Georgia State (Week 1)
Strengths: Elite defense, efficient QB play.
Weaknesses: Rushing attack inconsistent.
Ole Miss Rebels (4–0)
W 45–10 vs. Tulane (Week 4)
W 31–28 vs. Arkansas (Week 3)
W 27–24 vs. Kentucky (Week 2)
W 38–14 vs. Memphis (Week 1)
Strengths: Explosive offense (543 ypg, 12th nationally).
Weaknesses: Run defense porous.
Conference vs. Conference
Both teams are SEC West rivals.
This game has SEC Championship and CFP implications with both teams unbeaten.
Series History
All-time series: LSU leads 65–42–4.
Last meeting: Ole Miss beat LSU 29–26 in 2024.
Trend: The last two meetings were thrillers — LSU won 55–49 in 2023, Ole Miss edged LSU in 2024.
Betting Trends
LSU Tigers:
2–2 ATS in 2025.
5–2 ATS in last 7 SEC games.
4 of last 6 games have gone Under.
Ole Miss Rebels:
3–1 ATS in 2025.
6–1 ATS in last 7 home games.
2 of last 3 games have gone Over.
Historical Betting Results
2024: Ole Miss +3 covered in 29–26 win (Under cashed).
2023: LSU -2.5 covered in 55–49 win (Over cashed).
2022: LSU -1.5 covered in 45–20 win (Over cashed).
Game Odds
LSU Tigers – 2
Mississippi Rebels 54
Odds Courtesy of Sports Odd Direct as of Friday, September 26, 2025
