Venue & Logistics
Venue: Schmidt Stadium, Edwardsville, Pennsylvania (home of Wilkes University Colonels)
Kickoff Time: 12:00 PM ET (9:00 AM PT)
Weather Forecast (Edwardsville, PA)
Conditions: Partly sunny, warm early fall afternoon
Temperature: ~72°F (22°C) at kickoff, cooling to 66°F (19°C) by the fourth quarter
Winds: 5–9 mph from the northwest
Precipitation:
Impact: Ideal football weather; no disruptions expected
Injury Report
Muhlenberg Mules:
QB1 (ankle) – Probable
RB2 (hamstring) – Questionable
LB1 (shoulder) – Out
Wilkes Colonels:
WR2 (groin) – Game-time decision
DB1 (concussion protocol) – Out
OL starter (knee) – Probable
Key Player Matchups
Muhlenberg QB1 vs. Wilkes Secondary – Mules’ passing game has been efficient; Colonels’ depleted secondary must hold up.
Wilkes RB Committee vs. Muhlenberg Front Seven – Colonels’ ground game is their offensive anchor; Mules must control the trenches.
WR1 (Muhlenberg) vs. Wilkes Corners – With WR2 questionable, WR1 will be the focal point; Wilkes must double him to avoid explosive plays.
Special Teams: Both squads have shown inconsistency in the kicking game; field position could be decisive.
Series History
Head-to-Head: No recent official meetings recorded.
Context: This is a rare non-conference matchup between two Pennsylvania programs, adding intrigue to the early-season slate.
Betting Trends
Muhlenberg is 7-2 ATS in last 9 games overall.
Wilkes is 4-2 ATS in last 6 home games.
The Over has hit in 5 of Wilkes’ last 7 games due to high-scoring offense.
Muhlenberg is 4-1 SU in last 5 games.
Historical Betting Results
2024 (Muhlenberg): -10.5 vs. Montclair State, won 21-0 → Cover, Under
2024 (Wilkes): +3.5 vs. Catholic, won 40-15 → Cover, Over
2023 (Muhlenberg): -7.5 vs. Dickinson, won 42-14 → Cover, Over
Game Odds
Muhlenberg Mules – 7.5
Wilkes Colonels 51
Odds Courtesy of Sports Odd Direct as of Friday, September 19, 2025
