Venue & Logistics
Location: Armfield Athletic Center, Greensboro, North Carolina (home of Guilford College Quakers)
Kickoff Time: 1:00 PM ET (10:00 AM PT)
Conference: Old Dominion Athletic Conference (ODAC) – both teams are long-time league rivals
Weather Forecast (Greensboro, NC)
Temperature: ~74°F (23°C) at kickoff
Conditions: Mostly sunny with scattered clouds
Winds: 5–8 mph from the southwest
Precipitation:
Impact: Excellent early fall football weather, no major disruptions expected
Injury Report (as of latest updates)
Hampden-Sydney Tigers: No major reported injuries; offensive line depth remains a watchpoint after a physical start to the season.
Guilford Quakers: No confirmed long-term absences; defensive rotation expected after conceding 35 to Washington & Lee.
(Note: Division III programs often release limited injury details, so official confirmations may be sparse.)
Key Player Matchups
Quarterback Play:
Hampden-Sydney senior QB Carter Sido has thrown for 608 yards (35-of-66) with 8 TDs and 3 INTs through three games, while adding 104 rushing yards.
Guilford’s QB has struggled with consistency, managing just 7 points in a 35–7 loss to Washington & Lee (Sept 20, 2025).
Running Game:
Hampden-Sydney’s balanced attack has produced 38+ points in two of three games this season.
Guilford’s RB corps has been limited, averaging under 100 yards per game in September.
Defensive Edge:
Hampden-Sydney’s defense dominated Shenandoah in a 42–7 win (Sept 20, 2025), forcing multiple turnovers.
Guilford’s defense has been porous, conceding 40+ points in two of its first three games.
Recent Team Form
Hampden-Sydney Tigers (3–0 in 2025)
W 38–31 vs. Washington & Jefferson (Sept 13)
W 42–7 vs. Shenandoah (Sept 20)
W 38–9 vs. Delaware Valley (Sept 6)
Momentum: Ranked #25 in AFCA Coaches Poll, undefeated start, first 3–0 since 2011
Guilford Quakers (1–2 in 2025)
W 21–7 vs. Greensboro (Sept 7)
L 40–42 vs. Methodist (Sept 14)
L 7–35 @ Washington & Lee (Sept 20)
Struggles: Defense giving up big plays, offense inconsistent against ODAC opponents
Series History
All-time head-to-head: Hampden-Sydney leads 50–24
Recent dominance: Tigers have won 5 straight and 23 of the last 25 meetings
2024: Hampden-Sydney 31 – 0 Guilford
2023: Hampden-Sydney 42 – 21 Guilford
Trend: Hampden-Sydney has controlled the rivalry since the 1990s
Betting Trends
Hampden-Sydney is 3–0 ATS (against the spread) in 2025
Guilford is 1–2 ATS this season
The Over has hit in 2 of Hampden-Sydney’s 3 games
Guilford has failed to cover in 4 of its last 5 ODAC games
Historical Betting Results
2024: Hampden-Sydney (-14.5) covered in a 31–0 win (Total: Under 47.5)
2023: Hampden-Sydney (-10.5) covered in a 42–21 win (Total: Over 50.5)
Totals: Split results – one Over, one Under in the last two years
Game Odds
Hampden-Sydney Tigers – 17
Guilford Quakers 51
Odds Courtesy of Sports Odd Direct as of Friday, September 26, 2025
