Venue & Game Details
Location: Memorial Stadium, Clemson, SC
Kickoff: 3:30 p.m. ET
Broadcast: ACC Network / Fubo streaming
Weather Forecast: ~72°F at kickoff, partly cloudy, light winds 5–8 mph,
Team Recent Form
Clemson Tigers:
Last game: Defeated Boston College 41–10.
Trend: Offense averaging 26.3 PPG (81st nationally), defense allowing just 18.5 PPG (27th nationally).
SMU Mustangs:
Last game: Beat Stanford 34–10.
Trend: Offense averaging 34.0 PPG (42nd nationally), defense allowing 22.3 PPG (55th nationally).
Injury Report
Clemson: No major injuries reported; QB Cade Klubnik and WR Bryant Wesco Jr. healthy.
SMU: No major injuries reported; QB Kevin Jennings and RB Tomarion Harden expected to start.
Key Player Matchups
QB Cade Klubnik (Clemson): 1,530 yards, 11 TDs, 5 INTs, 65.8% completion; also 104 rushing yards, 2 TDs.
RB Adam Randall (Clemson): 404 rushing yards, 4 TDs; also 163 receiving yards, 3 TDs.
WR Bryant Wesco Jr. (Clemson): 537 yards, 6 TDs – explosive deep threat.
QB Kevin Jennings (SMU): 1,658 yards, 15 TDs, 6 INTs, 71.7% completion.
RB Tomarion Harden (SMU): 414 yards, 5 TDs – steady ground presence.
WR Romello Brinson (SMU): 484 yards, 3 TDs – reliable target.
Series History
This is the first-ever meeting between SMU and Clemson.
Betting Trends
Clemson is 2-4 ATS this season, 2-2 ATS as a 9.5+ point favorite.
SMU is 1-4 ATS this season.
Clemson games average 52.2 total points (slightly under line).
SMU games average 58.8 total points (slightly over line).
Historical Betting Results
Clemson has covered in 2 of last 3 games.
SMU has covered in 1 of last 3 games.
The Under has hit in 4 of 6 Clemson games and 4 of 6 SMU games.
Score Projection: Clemson 26 – SMU 25
Game Odds
SMU Mustangs 56
Clemson Tigers – 9.5
Odds Courtesy of Sports Odd Direct as of Friday, October 17, 2025
