NFL Game Preview: Indianapolis Colts (8-2) vs. Kansas City Chiefs (5-5)

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Venue & Game Details

Location: GEHA Field at Arrowhead Stadium, Kansas City, MO

Kickoff: Sunday, November 23, 2025, 1:00 PM ET

Broadcast: CBS: Jim Nantz, Tony Romo, Tracy Wolfson (field reporter)

Weather Updates

Forecast: Cool day, clear skies, temperatures in the mid-40s, winds 8–12 mph.

Impact: Passing may be slightly affected by wind, but overall conditions favor balanced offensive play.

Injury Report

Indianapolis Colts:

QB Daniel Jones – healthy, projected 237 passing yards.

RB Jonathan Taylor – probable, coming off 244 rushing yards and 3 TDs vs. Falcons.

WR Tyler Warren – healthy, 99 yards last game.

Kansas City Chiefs:

QB Patrick Mahomes – healthy, 2,625 passing yards, 18 TDs this season.

RB Kareem Hunt – probable, 353 rushing yards, 6 TDs.

TE Travis Kelce – healthy, 631 receiving yards, 4 TDs.

Key Player Matchups

Daniel Jones (IND QB) vs. Chiefs Secondary: Jones’ efficiency (19/26 completions last week) will be tested against a defense that has allowed big plays but thrives at home.

Jonathan Taylor (IND RB) vs. Chiefs Front Seven: Taylor’s dominance on the ground is the Colts’ biggest weapon against a KC defense allowing 4.2 YPC.

Patrick Mahomes (KC QB) vs. Colts Defense: Mahomes’ ability to extend plays is critical against a Colts defense that forced multiple sacks last week.

Travis Kelce (KC TE) vs. Colts Coverage: Kelce remains Mahomes’ top target, and his matchup against Indy’s linebackers could tilt momentum.

Team Records & Recent Forms

Indianapolis Colts:

1st in AFC South.

Road Record: 2–2.

Last Game: 31–25 OT win vs. Falcons.

Offense: 27.9 PPG, Defense: 20.4 PPG.

Kansas City Chiefs:

3rd in AFC West.

Home Record: 4–1.

Last Game: 22–19 win vs. Broncos.

Offense: 23.1 PPG, Defense: 24.7 PPG.

Series History

All-Time: Chiefs lead 13–11.

Recent: Colts upset Chiefs 20–17 in 2022; Chiefs won 30–24 in 2023.

Betting Trends

Colts: 4–1 in last 5 games; 2–2 ATS on the road.

Chiefs: 3–2 in last 5 games; 4–1 at home this season.

Totals: OVER has hit in 3 of last 4 Colts games; Chiefs games lean UNDER at Arrowhead.

Final Score Projection: Indianapolis Colts 28, Kansas City Chiefs 24

Reasoning: Taylor’s ground dominance and Jones’ efficiency should give Indy the edge. Mahomes and Kelce will keep KC competitive, especially at home, but the Colts’ balance and recent form tilt the matchup. Expect a close, high-scoring game with Indianapolis covering narrowly.

COLTS NOTES:

• QB DANIEL JONES completed 19 of 26 att. (73.1 pct.) for 255 yards & TD vs. INT in Week 10. Ranks 3rd in 2025 with 2,659 passing yards & is 1 of 2 (Drake Maye) to record 8+ games of 100+ passer rating in 2025. Is 1 of 2 (Drake Maye) to record 10+ games of 200+ pass yards. Is 1 of 3 QBs since 2021 to record 15 pass TDs & 5 rush TDs in first 10 games of a season (Josh Allen & Jalen Hurts). • RB JONATHAN TAYLOR had career-high & franchise record 286 scrimmage yards (244 rush, 42 rec.) & 3 rush TDs in Week 10. Needs 3 rush TDs to join HOFer LaDainian Tomlinson (2006) with 5 games of 3+ rush TDs in a season. Ranks 2nd in 2025 with 1,399 scrimmage yards. Leads league with 1,139 rushing yards, 17 scrimmage TDs & 15 rush TDs. Is 1 of 5 RBs since 2000 to record 1,000+ rush yards & 250+ rec. yards through first 10 weeks of a season. • WR ALEC PIERCE had 4 catches for 84 yards & 1st TD of season in Week 10. Aims for 5th in row 65+ rec. yards. Is 1 of 2 WRs (Jaxon Smith-Njigba) to record catch of 25+ yards in 7+ games. • TE TYLER WARREN led team with 8 catches for 99 yards in Week 10. Ranks 2nd among rookies with 50 receptions & 3rd with 617 receiving yards. 1 of 3 rookie TEs (Brock Bowers & Keith Jackson) to record 50+ receiving yards in 7 of first 10 games in career. • LB ZAIRE FRANKLIN had 10 tackles, 2 TFL & sack in Week 10. Since 2022 ranks tied-1st (Roquan Smith) with 10+ tackles in 30 games. • LB GERMAIN PRATT had 7 tackles, PD & FR in Week 10. • CB SAUCE GARDNER had 6 tackles & PD in Colts debut in Week 10. • S CAMRYN BYNUM had 5 tackles, sack & FF in Week 10. Has 5+ tackles in 3 of his past 4 games. • S NICK CROSS had 7 tackles & sack in Week 10. Ranks tied for 7th among safeties with 69 tackles. Is 1 of 3 safeties with 2.5+ sacks (2.5) this season.

CHIEFS NOTES:

• QB PATRICK MAHOMES passed for 276 yards & TD vs. INT in Week 11. Is 1 of 2 in 2025 (Drake Maye) to have 8+ games with 250+ pass yards. Can become 7th QB in NFL history to record 250+ pass yards & 3+ pass TDs in 5+ consecutive home games. Ranks 4th in 2025 with 233 completions & 2,625 pass yards. Had 321 yards & TD in only home meeting vs. Ind (10/06/19). • RB KAREEM HUNT had 59 rush yards & TD in Week 11. Aims for 4th in row with rush TD. Aims for 3rd in row with 50+ scrimmage yards. Had 2 TDs in last game vs. Ind. (10/22/23 w/ Cle.). • WR RASHEE RICE had 6 catches in Week 11. Aims for 5th in row with 4+ catches. Has scrimmage TD in 3 of his past 4 games. Has 80+ receiving yards in 2 of his past 3 games. • WR XAVIER WORTHY aims for 5th in row with 3+ catches. • TE TRAVIS KELCE led team with 9 catches for 91 yards & TD in Week 11. Has 84 career TDs & surpassed Priest Holmes for most TDs (84) in Chiefs history. Ranks 2nd among TEs in 2025 with 631 rec. yards. Ranks tied-4th among TEs in 2025 with 50 catches. • DT CHRIS JONES had 2 tackles & sack in Week 11. Ranks 5th among DL since entering the league in 2016 with 83.5 sacks. • LB NICK BOLTON had 6 tackles & PD in Week 11. Has 6+ tackles in 9 of his past 10 games. Is 1 of 8 players since entering the league in 2021 with 500+ tackles, 15+ PD, 4+ INT & 3+ FF. Had 9 tackles & career-high 2 sacks in last meeting vs. Ind. • LB DRUE TRANQUILL had 7 tackles & TFL in Week 11. Has 6+ tackles in 2 of his past 3 games. • DB CHAMARRI CONNER had 8 tackles & 2nd-career sack in Week 11. Has 5+ tackles in 5 of his past 6 games.

Game Odds

Indianapolis Colts            50.5

Kansas City Chiefs           – 3.5

Odds Courtesy of Sports Odd Direct as of Saturday, November 22, 2025