Venue & Game Details
Location: NRG Stadium, Houston, TX
Kickoff: 8:15 PM ET
Broadcast: Prime Video: Al Michaels, Kirk Herbstreit, Kaylee Hartung (field reporter)
Westwood One: Kevin Kugler, Marcel Reece
Weather Updates
Forecast: Clear skies, 71°F, light winds (5 mph).
Impact: With NRG’s retractable roof, weather will have minimal effect on gameplay.
Injury Report
Buffalo Bills:
WRs Joshua Palmer, Curtis Samuel, Mecole Hardman – listed on estimated injury report (questionable).
TE Dalton Kincaid – limited practice, game-time decision.
Houston Texans:
QB C.J. Stroud – concussion protocol, ruled out.
QB Davis Mills – starting in relief.
RB Jo’quavious Marks – probable.
WR Nico Collins – healthy, expected to play.
Key Player Matchups
Josh Allen (BUF QB) vs. Texans Secondary: Allen comes off a six-touchdown performance vs. Tampa Bay, testing a defense ranked mid-pack in passing yards allowed.
James Cook III (BUF RB) vs. Texans Front Seven: Cook already has 968 rushing yards, critical for balance against Houston’s aggressive pass rush.
Davis Mills (HOU QB) vs. Bills Defense: Mills has been steady (274 yards, 1 TD vs. Titans), but faces a Buffalo defense improving after a midseason slump.
Nico Collins (HOU WR) vs. Bills Coverage: Collins’ reliability (92 yards, 1 TD last week) is Houston’s best chance to stretch the field.
Team Recent Forms
Buffalo Bills:
2nd in AFC East.
Road Record: 3–2.
Last Game: 44–32 win vs. Tampa Bay.
Offense: 29.2 PPG (4th NFL).
Houston Texans:
3rd in AFC South.
Home Record: 3–2.
Last Game: 16–13 win vs. Titans.
Offense: 20.8 PPG (20th NFL).
Series History
All-Time: Bills vs. Texans series is competitive; Allen is 1–3 career vs. Houston.
Recent: Texans edged Buffalo 23–20 in 2024.
Betting Trends
Buffalo: 4–6 ATS this season; 6–1 when scoring 30+ points.
Houston: 3–1 in divisional play; 2–3 ATS at home.
Totals: Buffalo games lean OVER (high-scoring offense), Houston games lean UNDER (defensive grind).
Final Score Projection: Buffalo Bills 31, Houston Texans 20
Reasoning: Buffalo’s offense led by Allen and Cook should overwhelm Houston’s defense. Mills will keep the Texans competitive, but without Stroud, Houston lacks the firepower to match Buffalo’s pace. Expect Buffalo to cover and the total to lean OVER.
BILLS NOTES:
• QB JOSH ALLEN had 317 pass yards, 3 pass TDs, 40 rush yards & 3 rush TDs in Week 11, only player in NFL history with 300+ pass yards, 3 pass TDs & 3 rush TDs in a single game. Has 75 career reg.-season rush TDs, tied with Cam Newton for most by QB in NFL history. Has 213 reg.-season pass TDs, tied with HOFer Brett Favre for 5th-most by player in 1st 8 seasons in NFL history. Ranks 3rd with 10 rush TDs this season. • RB JAMES COOK had 114 scrimmage yards (66 rec., 48 rush) & rec. TD in Week 11. Ranks 5th among RBs with 1,158 scrimmage yards. Has 100+ scrimmage yards in 3 of his past 4 games. Had 99 scrimmage yards (82 rush, 17 rec.) & rush TD in last meeting. • RB TY JOHNSON had 61 rec. yards, including 52-yard TD, in Week 11. Has scrimmage TD in 2 of his past 3 games. • WR KHALIL SHAKIR has 5+ catches in 3 of his past 4 games. Aims for 3rd in row with 6+ catches on road. • WR TYRELL SHAVERS had team & career-high 4 catches for 90 yards & TD in Week 11. • DT DAQUAN JONES had 4 tackles, sack & FF in Week 11. Had 6 tackles & TFL in last meeting. • LB TERREL BERNARD co-led team with 11 tackles, 2 TFL & 2 PD in Week 11. Is 1 of 3 players in 2025 (Daiyan Henley & Andru Phillips) to record 10+ tackles, 2 TFL & 2 PD in single game. Aims for 4th in row with 5+ tackles & 3rd in row with TFL. Had 5 tackles & INT in last meeting. • S COLE BISHOP had 6 tackles & INT in Week 11. Aims for 3rd in row with INT. Aims for 4th in row with 6+ tackles & PD. • S JORDAN POYER co-led team with 11 tackles & PD in Week 11. Ranks 2nd among DBs since entering the league in 2013 with 9 games of 10+ tackles & PD. Aims for 5th in row with 5+ tackles.
TEXANS NOTES:
• QB DAVIS MILLS had 274 pass yards & TD in Week 11. Ranks 5th in NFL over last two weeks with 566 pass yards. Aims for 3rd in row with 250+ pass yards & TD. Aims for 4th in row with 250+ pass yards as a starter. • RB WOODY MARKS had 44 rush yards in Week 11. Aims for 3rd in row with 50+ scrimmage yards. Has 80+ scrimmage yards in 3 of his past 4 home games. Has 3 rush TDs at home this season. • WR NICO COLLINS led team with 9 catches for 92 yards & TD in Week 11. Aims for 4th in row with 7+ catches & 75 yards. Had 2 catches for 78 yards & TD in last meeting. • WR JAYDEN HIGGINS had 4 catches for 55 yards in Week 11. Aims for 3rd in row with 4+ catches & 40 yards. • TE DALTON SCHULTZ had 6 catches for 51 yards in Week 11. Tied-2nd among TEs in 2025 with 7 games of 5+ catches. Aims for 4th in row with 6+ catches & 50 yards. • DE WILL ANDERSON JR. had 4 tackles, 2 TFL, sack, FF & FR in Week 11. Is 1 of 3 in 2025 (Nick Bosa & T.J. Watt) to record 4+ tackles, 2 TFL, sack, FF & FR in single game. Tied-4th in AFC with 8 sacks in 2025. • DE DANIELLE HUNTER had 4 tackles, 1.5 sacks & TFL in Week 11. Since entering league in 2015, ranks 3rd with 108.5 sacks & ranks tied-3rd with 27 games with 1.5+ sacks. Aims for 3rd in row with 1.5+ sacks & TFL. Ranks tied-4th in 2025 with 9 sacks. • LB AZEEZ AL-SHAAIR had 6 tackles last week. Aims for 4th in row with 6+ tackles. Has PD in 4 of his past 5 home games. • CB KAMARI LASSITER had PD in Week 11 & has PD in 7 consecutive games, the longest active streak in NFL. • CB DEREK STINGLEY had 4 tackles & PD in Week 11. Has PD in 8 of his past 9 games in 2025. Aims for his 6th in row with PD
Game Odds
Buffalo Bills – 4.5
Houston Texans 43.5
Odds Courtesy of Sports Odd Direct as of Wednesday, November 19, 2025
