Venue & Game Information
Location: L&N Federal Credit Union Stadium, Louisville, KY
Kickoff: Friday, November 14, 2025, 7:30 p.m. ET
Broadcast: ESPN
Capacity: 61,000+ fans; Louisville’s home field is known for its loud, hostile environment
Weather Outlook
Forecast: Chilly evening, mid-40s°F at kickoff
Wind: 6–8 mph, minor impact on passing/kicking
Impact: Cold conditions favor Louisville’s run-heavy approach
Injury Report
Clemson: RB Adam Randall (ankle) probable; WR Antonio Williams (hamstring) expected to play.
Louisville: RB Isaac Brown (leg) questionable; QB Miller Moss (rib soreness) probable.
Team Recent Form
Clemson Tigers: Coming off a 24–10 win over Florida State, but overall inconsistent. Offense averages 22.7 points per game, defense allows 25.1 points per game.
Louisville Cardinals: Lost 29–26 to California last week, but still in ACC title contention. Offense averages 31.9 points per game, defense allows 21.8 points per game.
Player Matchups
QB Battle:
Clemson: Cade Klubnik – 1,875 yards, 12 TD, 7 INT, 62% completion.
Louisville: Miller Moss – 2,231 yards, 19 TD, 9 INT, 70% completion.
RBs:
Clemson: Adam Randall – 48 yards vs. FSU, 3.2 YPC.
Louisville: Keyjuan Brown – 136 yards vs. Cal, 9.7 YPC.
WRs:
Clemson: Antonio Williams – 62 yards, 1 TD vs. FSU.
Louisville: Caullin Lacy – 60 yards vs. Cal.
Defense: Clemson ranks 5th in ACC run defense (106.2 ypg); Louisville’s rushing attack averages 210 yards/game in wins.
Series History
Clemson leads the all-time series 8–1.
Louisville’s lone win came in 2024 under Jeff Brohm.
Last year: Louisville rushed for 210 yards in a 33–21 victory.
Betting Trends
Louisville: 3–6 ATS this season; 2–6 ATS as favorites of 3+ points.
Clemson: 3–6 ATS; 4 of 9 games have hit the Over.
Louisville has gone Over in 5 of 9 games.
Predicted Score: Louisville 27 – Clemson 20
Summary: This ACC showdown pits Clemson’s inconsistent offense against Louisville’s balanced attack. The Tigers’ defense is strong against the run, but Louisville’s rushing depth and home-field advantage tilt the matchup. Expect a competitive but controlled game, with Louisville favored to cover and the Under offering value.
Game Odds
Clemson Tigers 50
Louisville Cardinals – 3
Odds Courtesy of Sports Odd Direct as of Thursday, November 13, 2025
