Venue & Match Details
Stadium: Los Angeles Memorial Coliseum, Los Angeles, CA
Kickoff: 9:00 PM ET / 6:00 PM PT
Broadcast: FOX
Weather Forecast: Clear skies, 64°F at kickoff, light winds (5–7 mph). Ideal conditions for a night game in Southern California.
Injury Report
Northwestern Wildcats:
QB Preston Stone – active, but coming off a 2-INT game vs. Nebraska.
RB Caleb Komolafe – healthy, rushed for 125 yards and 2 TDs last week.
No major new injuries reported.
USC Trojans:
QB Jayden Maiava – healthy, dual-threat QB with 15 TDs this season.
RB King Miller – active, 129 rushing yards vs. Nebraska.
WR Makai Lemon – available, team’s leading receiver.
Player Matchups
QB Preston Stone (NW): 1,372 yards, 10 TDs, 9 INTs; must protect the ball against USC’s opportunistic defense.
QB Jayden Maiava (USC): 2,315 yards, 15 TDs, 5 INTs; adds mobility (62 rushing yards, 1 TD vs. Nebraska).
RB Caleb Komolafe (NW): 608 yards, 7 TDs; faces USC’s front seven.
RB King Miller (USC): 576 yards, 5 TDs; complements Maiava in the ground game.
WR Griffin Wilde (NW): 570 yards, 4 TDs; top downfield threat.
WR Makai Lemon (USC): 776 yards, 6 TDs; matchup nightmare for Northwestern’s secondary.
Team Form
Northwestern Wildcats:
Last 5: L–W–W–L–L
Offense: 360.3 YPG (91st FBS), 22.5 PPG (102nd)
Defense: 304.3 YPG allowed (19th), 16.8 PPG allowed (13th)
USC Trojans:
Last 5: W–L–W–L–W
Offense: 505.9 YPG (2nd FBS), 39.8 PPG (8th)
Defense: 355.1 YPG allowed (56th), 22.4 PPG allowed (53rd)
Series History
First-ever Big Ten meeting between the programs.
USC undefeated at home in 2025 (4–0).
Northwestern 2–2 on the road this season.
Betting Trends
USC: 4–4 ATS this season; 2–2 ATS as a 14+ point favorite.
Northwestern: 5–3 ATS; 2–0 ATS as a 14+ point underdog.
USC: 4 of 8 games Over the total.
Northwestern: 5 of 8 games Under the total.
Northwestern ranks 6th nationally in time of possession (33:23), while USC ranks 59th (30:22).
Projected Score: USC 31 – Northwestern 13
Game Odds
Northwestern Wildcats 50.5
USC Trojans – 14.5
Odds Courtesy of Sports Odd Direct as of Thursday, November 6, 2025
