Venue & Game Details
Location: Levi’s Stadium, 4900 Marie P DeBartolo Way, Santa Clara, CA 95054
Kickoff: 4:25 PM ET / 1:25 PM PT
Broadcast: FOX: Kevin Burkhardt, Tom Brady, Erin Andrews / Tom Rinaldi (field reporter)
Weather Forecast (Santa Clara)
Conditions: Sunny, mild
Temperature: Mid-60s °F at kickoff
Wind: 6–10 mph, light breeze
Factor: Ideal football weather, no weather-related impact expected
Injury Report
Rams:
WR Puka Nacua – questionable (ribs)
CB Darious Williams – questionable (shoulder)
WR Tutu Atwell – IR (hamstring)
CB Ahkello Witherspoon – IR (collarbone)
49ers:
QB Brock Purdy – questionable (toe)
WR Ricky Pearsall – questionable (knee)
DE Bryce Huff – questionable (hamstring)
C Jake Brendel – questionable (hamstring)
DE Mykel Williams – OUT (ACL)
Key Player Matchups
Matthew Stafford (Rams QB) vs. 49ers secondary – Stafford has 2,147 yards, 21 TDs, 2 INTs through 8 games. He threw for 389 yards in the Week 5 loss.
Kyren Williams (Rams RB) vs. 49ers front seven – Williams has 586 rushing yards, 6 total TDs; San Francisco’s run defense has been inconsistent without Fred Warner.
Christian McCaffrey (49ers RB) vs. Rams linebackers – McCaffrey has 596 rushing yards, 626 receiving yards, 8 TDs, making him the most versatile weapon on the field.
Puka Nacua (Rams WR) vs. Deommodore Lenoir (49ers CB) – Nacua leads LA with 711 receiving yards, while Lenoir is San Francisco’s top cover corner.
Recent Team Form
Rams: Riding a 3-game win streak, including a 34-10 rout of the Saints. Defense has allowed just 20 points total in last 3 games.
49ers: Beat Giants 34-24 last week, but have alternated wins and losses since Week 5. Injuries to the defensive front have hurt consistency.
Series History
All-time: 49ers lead 78-68-3
Recent: 49ers won Week 5, 26-23 in OT at SoFi Stadium
Last 10: 49ers lead 7-3
Betting Trends
Rams: 6-2 ATS; UNDER 5-3 this season
49ers: 5-4 ATS; OVER 6-3 this season
Head-to-head: 49ers have covered 8 straight as underdogs vs. Rams
Historical Betting Results
Rams games: 62.5% UNDER in 2025
49ers games: 66% OVER in 2025
Last meeting (Week 5): 49ers covered as +3.5 underdogs in OT win
Projected Final Score: Rams 27 – 49ers 23
RAMS NOTES:
• QB MATTHEW STAFFORD passed for 281 yards & 4 TDs vs. 0 INTs for 140.8 rating in Week 9, his 19th-career game with 4+ TD passes. Became 4th player (Tom Brady, Patrick Mahomes & Aaron Rodgers) with 20+ TD passes (NFLleading 21) & 2-or-fewer INTs (2) in his 1st 8 games of season. Has 398 reg. season TD passes & can become 9th player ever with 400 reg. season TD passes. Has 3+ TD passes in 4 of his past 5, incl. 389 pass yards & 3 TDs with 111 rating in Week 5 meeting. • RB KYREN WILLIAMS rushed for 114 yards & had 29th-career rush TD last week, his 11th-career game with 100+ rush yards. Has 50+ scrimmage yards in 36 straight games, longest active streak in NFL. Has 459 scrimmage yards (114.8 per game) & 7 TDs (4 rec., 3 rush) in 4 career games vs. SF, incl. 2+ TDs in 3 of 4 games. Aims for his 5th in row vs. SF with 100+ scrimmage yards. • WR DAVANTE ADAMS had 26th-career game with 2 rec. TDs last week, 6thmost such games in SB era. Leads NFL with 8 rec. TDs in 2025 & became 5th WR in SB era with 8+ rec. TDs in 6 straight seasons. Has 111 career rec. TD, tied-8th most in NFL history. Has 721 rec. yards (120.2 per game) & 7 rec. TDs in 6 career reg. season games vs. SF. • WR PUKA NACUA had 7 catches for 95 yards & 12th-career rec. TD last week. Has 5+ catches in 14 of his past 15 games. Has 85+ rec. yards in 6 of his 7 games in 2025 & 3 of his 4 career games vs. SF. • LB BYRON YOUNG has 0.5+ sacks in 4 of his 5 career games vs. SF. Ranks 3rd in NFL with career-high 9 sacks in 2025. • LB NATE LANDMAN had 8th-career FF last week. Had 14 tackles, 3 PD & TFL in Week 5 meeting. Aims for his 6th in row with 5+ tackles. • DE BRADEN FISKE had 1st sack of season last week. • CB EMMANUEL FORBES tied his career high with 3 PD & had 1st INT of season in Week 9. • S QUENTIN LAKE has career-high 10 PD in 2025. Had 11 tackles in Week 5 meeting.
49ERS NOTES:
• QB MAC JONES completed 19 of 24 atts. (season-high 79.2 pct.) for 235 yards & 2 TDs vs. 0 INTs for season-high 135.2 rating in Week 9. Is 1 of 3 in NFC (Sam Darnold & Matthew Stafford) with 260+ pass yards per game (261.7) in 2025 (min. 5 starts). Passed for 342 yards & 2 TDs in Week 5 meeting. • QB BROCK PURDY has 300+ pass yards & 2+ TD passes in 3 of his past 4 at home. • RB CHRISTIAN MCCAFFREY had 5 catches, 173 scrimmage yards (106 rush, 67 rec.) & 2 TDs (1 rush, 1 rec.) in Week 9, his 16th-career game with both rush TD & rec. TD, most in NFL history. Became 3rd player ever (HOFers Marshall Faulk & Walter Payton) with 10+ games (10) with 100+ rush yards & 50+ rec .yards. Has 33 career rec. TD, 2nd-most by RB in SB era. Leads NFL with 1,222 scrimmage yards & 8 games with 100+ scrimmage yards in 2025. Has 36 catches (7.2 per game), 790 scrimmage yards (158 per game) & 7 TDs (4 rush, 2 rec., 1 pass) in 5 career games vs. LAR, with 135+ scrimmage yards in each game. • TE GEORGE KITTLE has 50+ rec. yards in 5 of his past 6 at home vs. LAR. Needs 20 rec. yards to become 6th TE with 7,500+ rec. yards in 1st 9 career seasons. • WR JAUAN JENNINGS had 2nd rec. TD of season last week, his 15th-career TD catch. Has 5 rec. TDs in 6 career games vs. LAR. • WR KENDRICK BOURNE had 10 catches for 142 yards in Week 5 meeting. • LB TATUM BETHUNE had career-high 16 tackles & 1st-career PD last week. Since Week 6, leads NFL with 50 tackles, incl. 10+ tackles in all 4 games. • LB DEE WINTERS has PD in 2 of his past 3 at home. • DL SAM OKUAYINONU has sack in 2 of his past 3. • DL CLELIN FERRELL had sack last week in 1st game with SF this season. • CB RENARDO GREEN had 5th-career game with 2 PD last week. • CB UPTON STOUT is 1 of 3 rookie DBs (Jonas Sanker & Malaki Starks) with 6+ games (6) with 5+ tackles in 2025. • S MALIK MUSTAPHA aims for his 4th in row with 5+ tackles.
Game Odds
Los Angeles Rams – 4.5
San Francisco 49ers 49.5
Odds Courtesy of Sports Odd Direct as of Saturday, November 8, 2025
