Venue & Game Info
Location: SoFi Stadium, Inglewood, CA
Kickoff: 4:05 p.m. ET (1:05 p.m. PT)
Broadcast: CBS: Ian Eagle, JJ Watt, Evan Washburn (field reporter)
Surface: Artificial turf
Weather Forecast
Temperature: ~69°F
Conditions: Foggy, light haze
Wind: 5 mph SW
Impact: Minimal — indoor-style stadium with roof mitigates weather effects
Injury Report
Colts
WR Josh Downs (concussion) – DNP, unlikely
WR Ashton Dulin (chest) – Out
RB Tyler Goodson (groin) – Out
CB Charvarius Ward (concussion) – Questionable
CB Kenny Moore II (Achilles) – Limited
WR Alec Pierce (ankle) – Full, expected to play
Chargers
WR Quentin Johnston (hamstring) – Questionable
OT Joe Alt (ankle) – DNP
OT Trey Pipkins III (knee) – DNP
G Jamaree Salyer (knee) – Limited
LB Khalil Mack (elbow) – Limited, trending toward return
WR Keenan Allen (rest) – Expected to play
Player Matchups
Daniel Jones (IND) vs. Justin Herbert (LAC): Jones (1,502 yds, 8 TD, 3 INT) has the NFL’s highest QBR; Herbert (1,493 yds, 10 TD, 4 INT) remains elite despite OL injuries.
Jonathan Taylor (IND) vs. Chargers Run Defense: Taylor leads NFL with 603 yds, 7 TDs; Chargers allow 124.2 rush yds/game.
Tyler Warren (IND TE) vs. Chargers Linebackers: Rookie Warren (370 yds, 2 TDs) is a mismatch weapon.
Keenan Allen & Ladd McConkey (LAC) vs. Colts Secondary: Indy’s CB injuries could be exploited by Herbert’s quick passing game.
Colts O-Line vs. Chargers Pass Rush: Indy’s line ranks No. 1 in run-blocking; Chargers need Mack/Tuipulotu to generate pressure.
Team Recent Form
Colts (5-1): Wins over Cardinals (31-27), Raiders (40-6), Titans (41-20), Broncos (29-28), Dolphins (33-8). Only loss: Rams (27-20).
Chargers (4-2): Beat Dolphins (29-27) last week; also wins vs. Raiders, Broncos, Commanders. Losses to Giants and Commanders.
Series History
All-time: Chargers lead 20–11
Last Meeting: Chargers 20, Colts 3 (Dec. 2022)
Playoffs: Chargers lead 2–1 (notable wins in 2007 & 2008 postseason)
Betting Trends
Colts are 4-2 ATS this season; 6-1 in last 7 overall
Chargers are 2-3-1 ATS; 1-1-1 at home
Under is 4-2 in Chargers games; Colts games split 3-3
Colts have scored 30+ points in 4 of 6 games
Projection: Colts 30, Chargers 27
COLTS NOTES:
• COLTS have won 5 of 1st 6 games for 1st time since 2009. Lead NFL in scoring offense (32.3 points per game) in 2025. • QB DANIEL JONES passed for 212 yards & had 3 TDs (2 pass, 1 rush) with 101 rating in Week 6 & became 3rd QB ever (Josh Allen – 2020 & Dak Prescott – 2017) with TD pass, rush TD & 100+ rating in 3 of his team’s 1st 6 games of season. Is 1 of 2 (Drake Maye) with 100+ rating in 5 games in 2025. Ranks 3rd in comp. pct. (71.7) this season. • RB JONATHAN TAYLOR had 137 scrimmage yards (123 rush, 14 rec.) & leagueleading 7th rush TD of season last week. Leads NFL in scrimmage TDs (8) & ranks 3rd in scrimmage yards (750) in 2025. Aims for his 6th in row on road with 95+ scrimmage yards. Needs 146 scrimmage yards to reach 8,000 for his career. • TE TYLER WARREN (rookie) led team with 6 catches for 63 yards & had 2nd rec. TD of season last week. Can become 3rd rookie TE (Evan Engram & Heath Miller) since 2000 with scrimmage TD in 4 straight games. Leads all rookies in receptions (29) & ranks 3rd in rec. yards (370). • WR MICHAEL PITTMAN has 5+ catches & rec. TD in 3 of his past 4. Aims for his 4th in row on road with TD catch. • WR JOSH DOWNS had 6 catches & 1st rec. TD of season last week. • DT DEFOREST BUCKNER has 5 TFL in 2025, his 10th-straight season with 5+ TFL. Had 1.5 sacks & FF in last meeting. • DE KWITY PAYE had 4th-career 2-sack game in Week 6. Had FR in last meeting. • LB ZAIRE FRANKLIN aims for his 3rd in row on road with PD & 6th in row overall with 5+ tackles. Had 9 tackles & sack in last meeting. • LB GERMAINE PRATT had 11 tackles in team debut last week. Had 7 tackles & 2 PD in Week 1 vs. LAC (with LV). • CB MEKHI BLACKMON aims for his 3rd in row with INT & 6th in row with 5+ tackles. • S CAM BYNUM has TFL & PD in each of his 2 career games vs. LAC.
CHARGERS NOTES:
• QB JUSTIN HERBERT passed for 264 yards & 2 TDs vs. 0 INTs for 112.2 rating in Week 6 & became 3rd player ever (Patrick Mahomes & Russell Wilson) with 2+ TD passes & 100+ rating in 35+ games (35) in 1st 6 career seasons. Has 300+ pass yards in 2 of 3 home starts in 2025. • RB KIMANI VIDAL had career highs in scrimmage yards (138) & rush yards (124) & had his 1st-career rec. TD in Week 6. • WR KEENAN ALLEN has 5+ catches in 5 of 6 games this season & aims for his 3rd in row at SoFi Stadium with 5+ receptions. Has 28 receptions (9.3 per game) for 334 yards (111.3 per game) & 2 rec. TDs in 3 career games vs. Ind., incl. 8+ catches & 100+ rec. yards in each game. • WR LADD MCCONKEY led team with season highs in receptions (7) & rec. yards (100) & had 2nd TD catch of season in Week 6, his 4th-career game with 100+ rec. yards. Has 5+ catches in 5 of his past 6 at SoFi Stadium. • WR QUENTIN JOHNSTON has 70+ rec. yards in 4 of his 5 games in 2025. • TE ORONDE GADSEN (rookie) set career highs with 7 catches & 68 rec. yards in Week 6. • LB TULI TUIPULOTU had 5th sack of season last week. • LB ODAFE OWEH had sack in LAC debut in Week 6, his 24th-career sack. Had sack in his only career game vs. Ind. (10/11/21 w/ Bal.). • LB DAIYAN HENLEY has 7+ tackles in 5 of 6 games this season. • S DERWIN JAMES had 1st INT of season last week, his 10th-career INT. Ranks tied-1st among DBs with 5 TFL this season. Has 5+ tackles in 5 of his past 6 at SoFi Stadium. Had INT in last meeting. • S TONY JEFFERSON had 2nd INT of season last week. • CB BENJAMIN ST-JUSTE had 2nd-career INT in Week 6. Has PD in 3 of his past 4. • CB TARHEEB STILL aims for his 3rd in row with PD.
Game Odds
Indianapolis Colts 48.5
Los Angeles Chargers – 2.5
Odds Courtesy of Sports Odd Direct as of Saturday, October 18, 2025
