Venue & Game Details
Location: Raymond James Stadium, 4201 N Dale Mabry Hwy, Tampa, FL 33607
Kickoff: 4:25 p.m. ET / 1:25 p.m. PT
Broadcast: CBS: Jim Nantz, Tony Romo, Tracy Wolfson (field reporter)
Weather Forecast (Tampa)
Temperature: ~84°F at kickoff
Conditions: Partly sunny, humid
Impact: Heat and humidity could test San Francisco’s conditioning on a long East Coast trip
Injury Report
San Francisco 49ers
QB Brock Purdy (toe) – Questionable
QB Mac Jones (knee/oblique) – Questionable
WR Jauan Jennings (ankle/ribs) – Questionable
WR Ricky Pearsall (knee) – Questionable
WR Brandon Aiyuk (ACL/MCL) – Out (PUP)
TE George Kittle (hamstring) – Out (IR)
DE Nick Bosa (ACL) – Out (IR)
DT Kalia Davis (hand) – Doubtful
Tampa Bay Buccaneers
WR Mike Evans (hamstring) – Out
WR Chris Godwin (leg) – Questionable
RB Bucky Irving (shoulder) – Questionable
CB Jamel Dean (hip) – Questionable
CB Benjamin Morrison (hamstring) – Questionable
OT Tristan Wirfs (knee) – Questionable
LB Lavonte David (knee) – Questionable
Player Matchups
Baker Mayfield (TB QB) vs. 49ers Secondary: Mayfield has 1,283 yards, 10 TDs, 1 INT. He’s thriving with rookie WR Emeka Egbuka (445 yards, 5 TDs).
Christian McCaffrey (SF RB) vs. Bucs Run Defense: McCaffrey leads SF with 282 rushing yards and 387 receiving yards. Tampa’s front seven must contain him.
Emeka Egbuka (TB WR) vs. Deommodore Lenoir (SF CB): With Evans out, Egbuka is Mayfield’s go-to weapon.
49ers O-Line vs. Vita Vea (TB DT): Vea anchors a Bucs defense that can collapse the pocket.
Fred Warner (SF LB) vs. Bucs RBs: Warner leads SF with 50 tackles, key in limiting Irving/White.
Team Records & Recent Form
San Francisco 49ers (4-1)
Last 5: W @ LAR (26-23 OT), L vs JAX (26-21), W vs ARI (16-15), W @ NO (26-21), W @ SEA (17-13)
Strength: #1 passing offense (290.6 YPG)
Tampa Bay Buccaneers (4-1)
Last 5: W @ SEA (38-35), L vs PHI (31-25), W vs NYJ (29-27), W @ HOU (20-19), W @ ATL (23-20)
Strength: 6th in passing offense (243.4 YPG)
Series History
All-time: 49ers lead 19-7
Recent: 49ers have won 4 straight vs. Tampa Bay
Betting Trends
49ers: 3-2 ATS, 3-2 O/U
Buccaneers: 3-2 ATS, 3-2 O/U
49ers are 0-5 ATS in last 5 road games
5 of 49ers’ last 7 games have gone Over
Over is 14-6 in Bucs’ last 20 games
49ERS NOTES:
• QB MAC JONES completed 33 of 49 atts. (67.3 pct.) for 342 yards & 2 TDs vs. 0 INTs with 100.9 rating last week. Has 65+ comp. pct., 100+ rating & 2+ TD passes in 2 of his past 3 starts. Completed 31 of 40 atts. (77.5 pct.) for 275 yards & 2 TDs vs. INT for 101.6 rating in only career start vs. TB (10/3/21 w/ NE). • RB CHRISTIAN MCCAFFREY had 139 scrimmage yards (82 rec., 57 rush) & had TD catch in Week 5. Leads all RB in catches (39) & rec. yards (387) in 2025. Aims for his 6th in row with 105+ scrimmage yards. Has TD catch in 3 of his past 4. Had 107 scrimmage yards (68 rec., 39 rush) in last meeting. • WR KENDRICK BOURNE led team with 10 catches for career-high 142 yards last week. Had 5 catches for 58 yards in his last game vs. TB (10/3/21 w/ NE). • WR DEMARCUS ROBINSON had 3 catches for 39 yards in Week 5. Had 6 catches for 64 yards in his last game vs. TB (10/27/22 w/ Bal.). • TE JAKE TONGES had TD catch last week. Aims for his 3rd in row with TD catch. Is 1 of 4 TEs with TD catch in 3 games this season. • LB FRED WARNER had season-high 12 tackles in Week 5. Has 11+ tackles in 3 of his past 4. Has 2nd-most tackles in NFC in 2025 (50). Has 7+ tackles in each of his 5 career games vs. TB. • DE BRYCE HUFF had sack last week. Has sack in 3 of his past 4. Aims for his 5th in row with TFL. • DT ALFRED COLLINS (rookie) had 1st-career FF & FR in Week 5. • CB UPTON STOUT (rookie) had career-high 8 tackles last week. Has 5+ tackles in 3 of his past 4. • CB RENARDO GREEN had PD in Week 5. Has PD in 6 of his past 7. Had 5 tackles & 2 PD in last meeting. • CB DEOMMODORE LENOIR had 6 tackles & PD last week. Had 7 tackles last meeting. • S MARQUES SIGLE (rookie) led team with career-high 13 tackles & had PD in Week 5. Aims for his 3rd in row with PD.
BUCCANEERS NOTES:
• QB BAKER MAYFIELD completed 29 of 33 atts. (87.9 pct.) for 379 yards & 2 TDs vs. 0 INTs with 134.7 rating in Week 5. Is 1 of 4 QBs with 2+ TD passes in 4 games this season. Has TD pass in 16-straight home games, longest active streak in NFL. Completed 18 of 29 atts. (62.1 pct.) for 116 yards & TD in last meeting. • RB RACHAAD WHITE had 71 scrimmage yards (41 rush, 30 rec.) & 2 rush TDs last week. Has 4 catches in each of his past 2. Had 70 scrimmage yards (39 rec., 31 rush) & TD catch in last meeting. • WR EMEKA EGBUKA (rookie) led team with 7 catches for 163 yards & had TD catch in Week 5. Leads all rookies in catches (25), rec. yards (445) & TD catches (5) in 2025 & became 1st player ever with 25+ catches, 400+ rec. yards & 5+ TD catches in 1st 5 games. Aims for his 3rd in row with TD catch. • WR STERLING SHEPARD had 1st TD of season last week. • WR CHRIS GODWIN has 3 catches in both of his games this season. Has 6+ catches in 4 of his past at home. Had TD catch in his last game vs. SF at home (9/8/19). • TE CADE OTTON had 4 catches for 81 yards in Week 5. Has 4+ catches in each of 3 career games vs. SF. • DT VITA VEA has sack in 2 of his past 3 at home. • LB LAVONTE DAVID had 9 tackles, TFL & 1st INT of season last week. Has TFL in 4 of his past 5. Had 8 tackles in last meeting. • LB SIRVOCEA DENNIS had 8 tackles in Week 5, 2nd-straight week with 8 tackles. • LB HAASON REDDICK has TFL in 2 of his past 3. Aims for his 3rd in row vs. SF with 0.5+ sacks. • CB JACOB PARRISH (rookie) had career-high 9 tackles last week. Has TFL in 2 of his past 3. • S ANTOINE WINFIELD had PD in Week 5. Had 8 tackles & PD in last meeting. • S TYKEE SMITH had 6 tackles, 2 PD & 1st-career FR last week. Aims for his 4th in row with PD.
Game Odds
San Francisco 49ers 47.5
Tampa Bay Buccaneers – 3.5
Odds Courtesy of Sports Odd Direct as of Saturday, October 11, 2025
