Venue & Event Details
Kickoff: Sunday, October 5, 2025 – Kickoff 8:20 p.m. ET
Venue: Highmark Stadium, One Bills Drive, Orchard Park, NY 14127
Broadcast: NBC: Mike Tirico, Cris Collinsworth, Melissa Stark (field reporter)
Westwood One: Ryan Radtke, Mike Golic
This is a prime‑time AFC East showdown: Buffalo is undefeated at home since 2023 (13 straight wins), while New England seeks its first signature win under QB Drake Maye.
Weather Update (Orchard Park, NY)
Forecast: Clear skies, crisp fall evening
Temperature at Kickoff: ~65°F (18°C)
Humidity: ~60%
Wind: 6–9 mph
Impact: Ideal conditions for passing; no weather disruptions expected [^8].
Injury / Suspension Report
New England Patriots [^7]
QUESTIONABLE: WR Terry McLaurin (ankle)
QUESTIONABLE: WR Noah Brown (hamstring)
OUT: DT Milton Williams (ankle)
QB: Drake Maye (2nd year) – 74% completions, 988 yards, 7 TDs, 2 INTs
Buffalo Bills [^8]
OUT: LB Dorian Williams (injury)
OUT: CB Dorian Strong (injury)
QUESTIONABLE: OT Spencer Brown (calf)
QB: Josh Allen – 10 total TDs (7 pass, 3 rush), 1,000+ scrimmage yards through 4 games
Key Player Matchups
Drake Maye (NE) vs. Bills Secondary: Maye leads NFL in completion percentage (74%). Buffalo ranks #1 in pass defense (503 yards allowed through 4 games).
Stefon Diggs (NE) vs. Tre’Davious White (BUF): Diggs faces his former team for the first time since leaving Buffalo. Revenge factor looms large.
Josh Allen (BUF) vs. Patriots Pass Rush: Allen has been sacked only 5 times; New England has 12 sacks in 4 games.
James Cook (BUF) vs. Patriots Run Defense: Cook has 100+ scrimmage yards in every game; Patriots rank 2nd in rush defense (310 yards allowed).
Dalton Kincaid (BUF) vs. Patriots Linebackers: Patriots haven’t allowed a TE TD this season; Kincaid is emerging as a red‑zone weapon.
Team Records & Recent Form
New England Patriots
Record: 2‑2 (2nd in AFC East)
Last 5: L‑W‑L‑W
Last Game: 42‑13 win vs. Carolina (Week 4) – Maye 3 total TDs, 82% completions
Offense: 23.0 PPG (13th), 245 pass YPG (11th), 92 rush YPG (25th)
Defense: 21.5 PPG allowed (14th), 2nd vs. run, 26th vs. pass
Buffalo Bills
Record: 3‑1 (1st in AFC East)
Last 5: W‑W‑W‑W (undefeated in 2025)
Last Game: 31‑19 win vs. Saints (Week 4) – Allen 3 TDs, Cook 117 rush yards
Offense: 30.5 PPG (3rd), 1st in rushing offense (170 YPG)
Defense: 18.0 PPG allowed (6th), 1st vs. pass, 30th vs. run
Series History
All-time: Patriots lead 77‑51‑1 [^7]
Last Meeting: Jan. 5, 2025 – Bills 27, Patriots 21 (Week 18, Orchard Park)
Recent Trend: Bills have won 3 of last 5; Patriots upset Buffalo once in 2024.
At Highmark Stadium: Bills have won 6 of last 7.
Betting Trends
Bills are 2‑2 ATS this season.
Patriots are 2‑2 ATS.
Bills have not covered when favored by 7.5+ this year (0‑2).
Bills games have gone Over in 3 of 4.
Patriots are 1‑1 on the road this season.
Buffalo has scored 30+ points in all 4 games.
PATRIOTS NOTES
• PATRIOTS scored 40+ points (42) last week for 1st time since 2021. • QB DRAKE MAYE completed 14 of 17 atts. (82.4 pct.) for 203 yards & 2 TDs vs. 0 INTs with career-high 155.6 rating last week, becoming 3rd NE QB ever (Tom Brady & Steve Grogan) with 150+ rating in a game, min. 15 atts. Is 1st player 24-oryounger with 2+ TD passes & 75+ comp. pct. in 3 straight games, min. 15 atts. per game. Passed for 261 yards & 2 TDs with 90.2 rating in last road meeting. Leads qualified QBs with 74 comp. pct. in 2025. Making 1st-career start on SNF. • RB RHAMONDRE STEVENSON aims for his 4th in row on road with 75+ scrimmage yards. Had 73 scrimmage yards (60 rush, 13 rec.) & rush TD in last road meeting & has 70+ scrimmage yards in each of 5 career games vs. Buf. • RB TREVEYON HENDERSON (rookie) rushed for 1st-career TD last week. • RB ANTONIO GIBSON rushed for 1st TD of season in Week 4. • WR STEFON DIGGS led team with 6 catches for season-high 101 yards last week, 1st 100- yard game since 10/15/23. Has 5+ catches in 6 of his past 7 on road. Had 6 catches for 82 yards in his last game vs. Buf. (10/6/24 w/ Hou.). Has 85+ rec. yards in of his past 5 on SNF. Had 445 catches, 5,372 rec. yards & 37 rec. TDs over 4 seasons (2020-2023) with Buf. • WR MACK HOLLINS has TD catch in 2 of past 3. • TE HUNTER HENRY aims for 3rd in row with rec. TD. Had TD catch in last road meeting. • DE MILTON WILLIAMS has TFL in 3 of 4 games this season & 2 TFL in 2 of past 3. Had 2 sacks in his last game on SNF (11/24/24 vs. LAR, w/ Phi.). • LB K’LAVON CHAISSON had sack last week & has sack in 3 of 4 games this season. Aims for 4th in row with TFL. • LB ROBERT SPILLANE aims for 3rd in row with 10+ tackles. Has PD in 2 of past 3. Had 14 tackles & sack in his last game vs. Buf. (9/17/23 w/ LV). • LB JACK GIBBENS had season-high 9 tackles last week. Aims for 3rd in row with TFL. • CB MARCUS JONES had 87-yard PR-TD last week, 3rd-longest PR-TD in NE history
BILLS NOTES
• BILLS can begin 5-0 for 4th time in franchise history & 1st since 1991. Are 4th team in NFL history to win 14 straight reg. season home games with 24+ pts. in each game. • QB JOSH ALLEN completed 16 of 22 atts. (72.7 pct.) for 209 yards & 2 TDs vs. INT with 113.6 rating & rushed for 45 yards & TD last week, 27th-career game with 2+ TD passes & rush TD, most in NFL history. Has 2+ TD passes & 110+ rating in 3 of 4 games this season. Has rush TD in 3 of his past 4 at home. Is 8-2 in 10 career starts on SNF. • RB JAMES COOK led team with 135 scrimmage yards (117 rush, 18 rec.) & had rush TD last week & is 6th player in SB era with 100+ scrimmage yards & rush TD in each of team’s 1st 4 games of season. Aims for his 9th in row overall in reg. season & 3rd in row vs. NE with rush TD. Aims for his 3rd in row on SNF with 100+ scrimmage yards & rush TD. Leads NFL with 5 rush TDs & ranks 2nd with 401 rush yards in 2025. • WR KHALIL SHAKIR had 5 catches for season-high 69 yards & TD in Week 4. Aims for 3rd in row with rec. TD. • WR KEON COLEMAN had 45 rec. yards last week. • TE DALTON KINCAID had TD catch in Week 4 & is only TE in NFL with rec. TD in 3 games this season. Has 5+ catches in 3 of 4 career games on SNF. • DE JOEY BOSA had sack & FF last week. Is 1st player since 2020 (Myles Garrett) with FF in 3 of team’s 1st 4 games of season. Has sack in 2 of past 3. Has 5 sacks in 8 career games on SNF. Leads NFL with 4 FFs in 2025. • DE GREG ROUSSEAU had FF in last home meeting. Has TFL in 3 of his past 4 on SNF. • DE A.J. EPENESA had 1st sack of season in Week 4. Has TFL in 2 of his past 3 vs. NE. • DT DAQUAN JONES had sack last week & has sack in 2 of past 3. • LB TERREL BERNARD aims for his 4th in row vs. NE with 10+ tackles. • CB TRE’AVIOUS WHITE led team with season-high 7 tackles last week. Has TFL in each of his 3 games this season & PD in 2 of 3. Aims for his 3rd in row vs. NE with PD. • S COLE BISHOP had 5 tackles & 1st-career INT in Week 4.
Game Odds
New England Patriots 49.5
Buffalo Bills – 8.5
Odds Courtesy of Sports Odd Direct as of Saturday, October 4, 2025
