Time: 3:30 PM ET (ESPN2)
Venue: L&N Federal Credit Union Stadium, 2800 S. Floyd Street, Louisville, KY 40209
Capacity: 61,000
Weather Forecast (Louisville, KY)
Kickoff: 83°F, partly cloudy
End of Game: ~75°F, clear skies
Rain Chance: <10%
Wind: 5–8 mph
Impact: Excellent football conditions, minimal weather effect
Injury Report
Virginia Cavaliers (4-1, 2-0 ACC):
OL Monroe Mills – Out (season-ending)
DB Daniel Brown – Out (undisclosed)
WR David Washington Jr. – Out (shoulder)
QB Chandler Morris – Probable (hand, played through vs. FSU)
Louisville Cardinals (4-0, 1-0 ACC):
No major injuries reported
Key Player Matchups
Quarterbacks:
Virginia: Chandler Morris – 1,279 yds, 10 TD, 4 INT, 71.6% comp; 169 rush yds, 4 TD
Louisville: Miller Moss – 1,029 yds, 5 TD, 3 INT, 65.6% comp
Running Backs:
Virginia: J’mari Taylor – 397 yds, 7 TD
Louisville: Isaac Brown – 268 yds, 3 TD
Receivers:
Virginia: Trell Harris – 366 yds, 3 TD
Louisville: Chris Bell – 332 yds, 2 TD
Defensive Leaders:
Virginia: Daniel Rickert – 3.5 sacks; Devin Neal – 26 tackles
Louisville: Clev Lubin – 3.5 sacks; TJ Quinn – 22 tackles, 2 INT
Recent Team Form
Virginia (4-1):
W 46-38 (2OT) vs Florida State
W 48-20 vs Stanford
W 55-16 vs William & Mary
L 35-31 @ NC State
W 48-7 vs Coastal Carolina
Louisville (4-0):
W 34-27 @ Pittsburgh
W 40-17 vs Bowling Green
W 28-14 vs James Madison
W 51-17 vs Eastern Kentucky
Team Records
Virginia: 4-1 overall, 2-0 ACC
Louisville: 4-0 overall, 1-0 ACC
Series History
All-Time: Louisville leads 8–5
Current Streak: Louisville has won 3 straight (2022–2024)
Last Meeting (2024): Louisville 24, Virginia 20
At Louisville: Cardinals 5–1 vs Cavaliers since joining ACC
Betting Trends
Virginia: 4-1 ATS in 2025; 4 of 5 games OVER
Louisville: 1-3 ATS; 3 of 4 games OVER
Head-to-Head: Louisville 3-0 SU last 3 vs Virginia; 2 of last 3 UNDER
Situational: Virginia 6-0 ATS in last 6 October games as underdog
Historical Betting Results
2024: Louisville 24, Virginia 20 (UVA +7.5 covered, Under 54 hit)
2023: Louisville 31, Virginia 24 (UVA +20.5 covered, Over 50.5 hit)
2022: Louisville 34, Virginia 17 (LOU -1.5 covered, Over 48 hit)
2021: Virginia 34, Louisville 33 (UVA +2.5 covered, Over 69.5 hit)
Projected Score: Louisville 33, Virginia 28
Game Odds
Virginia Cavaliers 61
Louisville Cardinals – 6.5
Odds Courtesy of Sports Odd Direct as of Friday, October 3, 2025
