Time: 8:15 PM ET (5:15 PM PT) – Thursday Night Football on Prime Video
Venue: SoFi Stadium, 1001 Stadium Drive, Inglewood, CA 90301
Capacity: 70,240
Broadcast: Prime Video: Al Michaels, Kirk Herbstreit, Kaylee Hartung (field reporter)
Westwood One: Kevin Kugler, Ross Tucker
Weather Forecast (Inglewood, CA)
Kickoff: 71°F, clear skies
End of Game: ~66°F, mild evening
Rain Chance: 0%
Wind: 5–7 mph, negligible impact
Impact: Perfect conditions for passing and kicking
Injury Report
San Francisco 49ers
QB Brock Purdy – Out (toe)
WR Ricky Pearsall – Out (knee)
WR Jauan Jennings – Out (ankle/rib)
WR Jordan Watkins – Out (calf)
DE Robert Beal Jr. – Out (ankle)
DT CJ West – Questionable (thumb)
CB Renardo Green – Probable (neck)
DE Yetur Gross-Matos – Probable (knee)
Los Angeles Rams
TE Tyler Higbee – Doubtful (hip)
OT Rob Havenstein – Doubtful (ankle)
CB Ahkello Witherspoon – Out (collarbone, IR)
LB Keir Thomas – Out (IR)
Key Player Matchups
QB Battle:
49ers: Mac Jones (starting for Purdy) – 563 yds, 4 TD, 1 INT, 66.3% comp
Rams: Matthew Stafford – 1,114 yds, 8 TD, 2 INT, 67.6% comp
Skill Players:
49ers RB Christian McCaffrey – 225 rush yds, 305 rec yds, 2 TD (dual-threat weapon)
Rams WR Puka Nacua – 42 rec, 503 yds, 1 TD (NFL leader in receptions & yards)
Rams WR Davante Adams – 269 yds, 3 TD (veteran red-zone threat)
Defensive Stars:
49ers LB Fred Warner – 38 tackles, 2 TFL, 3 PD
Rams LB Byron Young – 23 tackles, 7 TFL, 5 sacks (tied NFL lead)
Rams S Kamren Curl – 35 tackles, 2 INT
Recent Team Form
San Francisco 49ers (3-1):
L 26-21 vs Jaguars
W 16-15 vs Cardinals
W 26-21 @ Saints
W 17-13 @ Seahawks
Los Angeles Rams (3-1):
W 27-20 vs Colts
L 33-26 @ Eagles
W 33-19 @ Titans
W 14-9 vs Texans
49ERS NOTES
• QB BROCK PURDY passed for 309 yards & 2 TDs last week, his 11th-career 300-yard game, 2nd-most in NFL since 2023. Aims for his 5th in row with 275+ pass yards & 2+ TD passes. Passed for 292 yards & 3 TDs vs. 0 INTs for 137.1 rating in last road meeting (9/22/24). • RB CHRISTIAN MCCAFFREY had 6 catches, 141 scrimmage yards (92 rec., 49 rush) & 31st-career rec. TD last week. Is 1 of 3 RBs (James Cook & Bijan Robinson) with 100+ scrimmage yards in each of 1st 4 weeks. Ranks 3rd in NFL in scrimmage yards (530) & receptions (31). Has 28 receptions (7 per game), 651 scrimmage yards (162.8 per game) & 5 TDs (4 rush, 1 rec.) in 4 career games vs. LAR, incl. 135+ scrimmage yards in each game. Aims for his 4th in row on Thursday with 115+ scrimmage yards & rush TD. • WR RICKY PEARSALL ranks 4th in NFL with 327 rec. yards in 2025 & has 50+ rec. yards in 5 of his past 6. Aims for his 8th in row with 4+ catches. • WR JAUAN JENNINGS has 50+ rec. yards in 4 of his past 5 on road. Had career highs in catches (11), rec. yards (175) & rec. TDs (3) in last road meeting (9/22/24). • TE JAKE TONGES had career-high 58 rec. yards & 2nd-career TD catch last week. • LB FRED WARNER had 8 tackles & 17th-career FF last week. Had 15 tackles in last meeting. Has PD in 4 of his past 5 vs. LAR. Has 79 tackles (8.8 per game) in 9 career Thursday games. • LB DEE WINTERS led team with career-high 10 tackles & had TFL & PD in Week 4. Aims for his 3rd in row with PD. • DL BRYCE HUFF has sack in 2 of his past 3 & aims for his 4th in row with TFL. • CB DEOMMODORE LENOIR aims for his 4th in row with TFL. Had 2 PD in last meeting. • S MARQUES SIGLE had career-best 8 tackles & 1st-career PD last week & is only rookie DB with 5+ tackles in each of 1st 4 weeks.
RAMS NOTES
• QB MATTHEW STAFFORD passed for 375 yards & 3 TDs vs. 0 INTs for 123.5 rating last week, his 18th-career game with 375+ pass yards. Aims for his 4th in row with 2+ TD passes. Has won 4 of his past 5 Thursday starts. • RB KYREN WILLIAMS had 94 scrimmage yards (77 rush, 17 rec.) last week & has 50+ scrimmage yards in 32 straight games, longest active streak in NFL. Has 12 TDs (10 rush, 2 rec.) in his past 10 at home. Has 328 scrimmage yards (109.3 per game) & 5 TDs (3 rush, 2 rec.) in 3 career games vs. SF, incl. 3 TDs (2 rush, 1 rec.) in last home meeting (9/22/24). Aims for his 4th in row on Thursday with 100+ scrmmage yards. • WR PUKA NACUA had 13 receptions for career-high 170 yards & 10th-career TD catch last week, his 7th-career game with 10+ catches & 100+ rec. yards. Became 2nd player ever (Cooper Kupp – 2022) with 10+ catches & 100+ rec. yards in 3 of his team’s 1st 4 games of season. Leads NFL with 42 receptions, tied-most by player in team’s 1st 4 games of season all-time. Had career-high 15 receptions for 147 yards in his only career home game vs. SF (9/17/23). • WR DAVANTE ADAMS aims for his 4th in row with rec. TD & 5th in row with 50+ rec. yards. Has 106 career reg. season rec. TDs, tied with Mike Evans for most among active players & tied 9th-most in NFL history. Has 46 receptions (9.2 per game) for 633 yards (126.6 per game) & 7 rec. TDs in 5 career games vs. SF, with rec. TD in each game & 7+ catches & 130+ rec. yards in 4 of 5 games. • LB BYRON YOUNG is 1 of 2 (Brian Burns) with sack in each of 1st 4 weeks. Has sack in 3 of his 4 career games vs. SF & aims for his 4th in row vs. SF with TFL. • LB JARED VERSE aims for his 3rd in row with sack & FF. • DE KOBIE TURNER had 2 sacks in last meeting. • S KAM CURL had career-high 3 PD & 1st-career game with 2 INTs last week. Aims for his 7th in row with 5+ tackles. Had 2 PD in last meeting. • S QUENTIN LAKE had 2 PD in last meeting. Aims for his 4th in row with 5+ tackles.
Team Records
San Francisco 49ers: 3-1 overall, 2-0 away
Los Angeles Rams: 3-1 overall, 2-0 home
Series History
All-Time: 49ers lead 78–71–3
Last Meeting (Dec 12, 2024): Rams 12, 49ers 6
Recent Trend: Rams have won 3 straight after 9 consecutive 49ers wins
Coaching Note: Kyle Shanahan is 10-7 vs Sean McVay
Betting Trends
49ers: 2-2 ATS in 2025; 2-2 O/U
Rams: 3-1 ATS; 2-2 O/U
Head-to-Head: Rams 3-0 ATS last 3 vs 49ers (all as underdogs)
Favorites: In last 10 meetings, favorites covered only twice
Totals: Last 3 games in LA have gone OVER
Historical Betting Results
Dec 2024: Rams 12, 49ers 6 (Rams +3 covered, Under 48.5)
Sep 2024: Rams 27, 49ers 24 (Rams +6 covered, Over 44.5)
Jan 2024: Rams 21, 49ers 20 (Rams +5.5 covered, Over 40)
Sep 2023: 49ers 30, Rams 23 (49ers -7.5 failed, Over 45 hit)
Oct 2022: 49ers 31, Rams 14 (49ers -1 covered, Over 42 hit)
Projected Score: Rams 24, 49ers 20
Game Odds
San Francisco 49ers 45.5
Los Angeles Rams – 8.5
Odds Courtesy of Sports Odd Direct as of Wednesday, October 1, 2025
