Kickoff: 8:15 PM MT (10:15 PM ET)
Venue: Folsom Field, Boulder, Colorado (Capacity: ~50,183)
Broadcast: ESPN
Weather Forecast (Boulder, CO – Sept. 20, 2025)
Temperature: ~72°F (22°C) at kickoff, cooling into the 60s by the 4th quarter
Conditions: Clear skies, low humidity, light winds (5–8 mph)
Impact: Ideal Rocky Mountain evening; no weather disruptions expected.
Injury Report
Wyoming Cowboys (Mountain West):
QB Kaden Anderson (starter, 2 TDs, 2 INTs through 3 games) healthy.
RB Harrison Waylee (team’s leading rusher, 245 yards, 2 TDs) available.
WR Will Pelissier (team-high 118 yards) active.
Defense intact, led by LB Shae Suiaunoa.
Colorado Buffaloes (Big 12):
QB Ryan Staub (54% completions, 1 TD, 2 INTs vs. Houston) expected to start, though QB rotation possible.
WR Travis Hunter (two-way star, 187 receiving yards) available.
WR Omarion Miller (team-high 210 yards, 1 TD) active.
Defense thin in secondary; DB Cormani McClain questionable.
Key Player Matchups
QB Kaden Anderson (Wyoming) vs. Colorado Secondary
Anderson has been steady but not explosive; Colorado’s DBs have struggled, allowing 6.8 yards per play.
RB Harrison Waylee (Wyoming) vs. Colorado Front Seven
Waylee’s ability to churn out yards will be critical to controlling tempo.
QB Ryan Staub (Colorado) vs. Wyoming Pass Rush
Staub has been inconsistent; Wyoming’s defense ranks top-30 nationally in EPA/play allowed.
WR Travis Hunter (Colorado) vs. Wyoming Corners
Hunter is Colorado’s most dynamic weapon; Wyoming must double him in key situations.
Recent Team Form
Wyoming Cowboys (2–1, Mountain West)
8/30/25: W 24–3 vs. Akron
9/6/25: W 17–4 vs. Northern Iowa
9/13/25: L 31–6 @ Utah
Trend: Defense stout (allowing just 12.7 PPG), offense limited in explosiveness.
Colorado Buffaloes (1–2, Big 12)
8/30/25: L 34–28 vs. Georgia Tech
9/6/25: W 45–17 vs. Delaware
9/13/25: L 36–20 @ Houston
Trend: Offense inconsistent, QB play unsettled, defense regressed from 2024 form.
Series History
Colorado leads the all-time series 26–2–1.
Last meeting: 2009, Colorado won 24–0 in Boulder.
Wyoming’s last win came in 1935.
Betting Trends
Wyoming:
2–1 ATS in 2025.
2–8 O/U in last 10 games dating back to 2024.
Defense-driven unders common.
Colorado:
1–2 ATS in 2025.
2 of 3 games have gone under the total.
0–4 ATS in last 4 vs. Mountain West opponents.
Head-to-Head:
Colorado has won 8 straight meetings.
Last 3 matchups have gone under the total.
Historical Betting Results
Wyoming: Profitable ATS as a double-digit underdog; defense keeps games close.
Colorado: Struggles ATS as a favorite; QB instability has led to inconsistent results.
MWC vs. Big 12: Mountain West teams cover ~55% of the time in these matchups.
Game Odds
Wyoming Cowboys 45
Colorado Buffaloes – 12.5
Odds Courtesy of Sports Odd Direct as of Friday, September 19, 2025
