Venue & Logistics
Venue: Highmark Stadium, Orchard Park, New York
Kickoff Time: 8:15 PM ET (Amazon Prime Video)
Broadcast: Prime Video: Al Michaels, Kirk Herbstreit, Kaylee Hartung (field reporter)
Westwood One: Jason Horowitz, Ross Tucker
Weather Forecast (Orchard Park, NY)
Conditions: Partly cloudy, cool evening
Temperature: ~66°F (19°C) at kickoff, dipping to 61°F (16°C) by the fourth quarter
Winds: 8–12 mph from the west
Precipitation: ~20% chance of light showers
Impact: Slight wind could affect deep passing and kicking
Injury Report
Miami Dolphins:
QB Tua Tagovailoa (ankle) – Probable
RB Raheem Mostert (hamstring) – Questionable
LT Terron Armstead (knee) – Out
CB Jalen Ramsey (shoulder) – Probable
Buffalo Bills:
WR Keon Coleman (groin) – Game-time decision
DB Christian Benford (concussion protocol) – Out
OL starter (ankle) – Probable
Key Player Matchups
Tua Tagovailoa vs. Bills’ Pass Rush – Tua has 3 TDs but 3 INTs through two games; Buffalo’s front has been disruptive.
Tyreek Hill & Jaylen Waddle vs. Bills Secondary – Miami’s speed duo must exploit a banged-up Buffalo secondary.
Josh Allen vs. Dolphins’ Pass Defense – Allen has 542 yards and 2 TDs with no INTs; Miami has allowed 60 points in two games.
James Cook vs. Dolphins’ Run Defense – Cook leads Buffalo with 176 rushing yards and 3 TDs; Miami has struggled against the run.
Recent Team Form
Miami Dolphins (0-2):
L vs. New England 33-27 (Week 2)
L vs. Indianapolis 27-8 (Week 1)
Offense averaging 17.5 PPG; defense allowing 30.0 PPG.
Buffalo Bills (2-0):
W vs. NY Jets 30-10 (Week 2)
W vs. Baltimore 27-24 (Week 1)
Offense averaging 28.5 PPG; defense allowing 17.0 PPG.
Series History
All-Time Meetings: Dolphins lead 62–58–1
Recent Trend: Bills have won 11 of the last 13 matchups
Most Recent: Buffalo swept Miami in 2024
Betting Trends
Bills have won 14 straight home games vs. opponents on a losing streak.
Dolphins have lost 8 straight road games vs. AFC opponents on a winning streak.
Dolphins are 1-8 ATS in last 9 as underdogs vs. AFC opponents.
Bills are 7-1 ATS in last 8 as favorites following a division game.
Road team has covered in 5 of last 6 Dolphins-Bills meetings.
Historical Betting Results
2024 (Week 18): Bills -7.5, won 27-14 → Cover, Under
2024 (Week 2): Bills -6.5, won 31-20 → Cover, Over
2023 (Wild Card): Bills -10.5, won 34-31 → No Cover, Over
DOLPHINS NOTES:
• QB TUA TAGOVAILOA completed 26 of 32 atts. (81.3 pct.) for 315 yards & 2 TDs vs. INT with 115.5 rating last week, 4th-career game with 80+ comp. pct. & 300+ pass yards, tied 3rd-most among active players. Has 70+ comp. pct. in 4 of his past 5 road starts. Completed 25 of 28 ats. (89.3 pct.) for 231 yards & 2 TDs vs. 0 INTs with 124.9 rating in last meeting. Aims for his 5th in row vs. division with 2+ TD passes & 100+ rating. • RB DE’VON ACHANE led team with 122 scrimmage yards (career-high 92 rec., 30 rush) & had TD catch last week. Is 1 of 2 RBs (Chuba Hubbard) with rec. TD in each of 1st 2 weeks of season. Aims for his 4th in row with 75+ scrimmage yards & TD. Has 467 scrimmage yards (116.8 per game) & 6 TDs (4 rush, 2 rec.) in 4 career games vs. Buf. Has TD catch in each of 2 career Thursday games. • WR TYREEK HILL had 6 catches for 109 yards in Week 2, 37th-career 100- yard game, 5th-most among active WRs. Had 80 rec. yards in last meeting & has 55+ rec. yards in 4 of his past 5 vs. Buf. Has 905 rec. yards (90.5 per game) & 7 rec. TDs in 10 career Thursday games. • WR JAYLEN WADDLE had 5 catches for 68 yards & 1st TD of season last week. Had TD catch in last meeting. • WR NICK WESTBROOK-IKHINE had TD catch in his last game vs. Buf. (10/20/24 w/ Ten.). • LB BRADLEY CHUBB is 1 of 6 LBs with sack in each of 1st 2 weeks of season. Has 7 sacks & 2 FFs in 3 career Thursday games, with 2+ sacks in each game. • LB JORDYN BROOKS had 8 tackles & 1st sack of season last week. Aims for 3rd in row with 8+ tackles & TFL. Has TFL in 10 of his past 11. • LB CHOP ROBINSON had 1st sack of season in Week 2. Had sack in last meeting. Aims for his 3rd in row vs. Buf. with TFL. • LB TYREL DODSON led team with 9 tackles last week. Aims for 3rd in row with 9+ tackles. Had 7 tackles in his last game vs. Buf. (10/27/24 w/ Sea.). • S MINKAH FITZPATRICK aims for 3rd in row with 7+ tackles.
BILLS NOTES:
• BILLS can begin 3-0 for 2nd-consecutive season & 4th time under HC Sean McDermott. Lead NFL with 450 yards/game & rank 2nd with 35.5 points/game. Have won 12 straight reg. season home games, 2nd-longest streak in Buf. history. • QB JOSH ALLEN totaled 207 yards (148 pass, 59 rush) with 0 INTs last week. Has 0 INTs in 10 of his past 11 starts, incl. playoffs. Has 2+ TD passes in 14 of 15 career starts vs. Mia., with 90+ rating in each of past 8, incl. playoffs. Is 7-0 with 107.4 rating in 7 career starts on Thursday. • RB JAMES COOK rushed for 132 yards & 2 TDs last week, 5th game with 2+ rush TDs since 2024, tied-most in NFL. Is only player in NFL with 100+ scrimmage yards & rush TD in each of 1st 2 weeks of season. Has rush TD in 6 straight reg. season games, 2nd-longest active streak in NFL. Has 6 TDs (5 rush, 1 rec.) in his past 5 in primetime. Tied for NFL lead with 3 rush TDs in 2025. • WR JOSHUA PALMER led team with 47 rec. yards in Week 2. Aims for his 5th in row with 40+ rec. yards. Has TD catch in 2 of his past 3 on Thursday. • WR KEON COLEMAN aims for his 3rd in row at home in reg. season with rec. TD. • WR ELIJAH MOORE had 2nd-career rush TD last week. • TE DALTON KINCAID has 4 catches in 4 of past 5. • DE JOEY BOSA had career-high 2 FFs & sack last week, only player with 2 FFs in a game this season & only player with FF in each of 1st 2 weeks. Has sack in 2 of his past 3 on Thursday. • DE GREG ROUSSEAU had PD & half sack last week. Aims for his 4th in row in reg. season with PD. Had 3 TFL & sack in last meeting & aims for his 5th in row vs. Mia. with TFL. • DT ED OLIVER aims for 3rd in row at home in reg. season with sack. Has sack in 3 of his past 4 on Thursday. • DT DAQUAN JONES had 18th-career sack in Week 2. • S COLE BISHOP had 5 tackles & 1st-career sack last week.
Game Odds
Miami Dolphins 50
Buffalo Bills – 12
Odds Courtesy of Sports Odd Direct as of Wednesday, September 17, 2025
