Venue & Game Details
Kickoff: 1:00 PM ET / 10:00 AM PT
Venue: Caesars Superdome, 1500 Sugar Bowl Drive, New Orleans, LA 70112
Broadcast: FOX: Kevin Kugler, Daryl Johnston, Allison Williams (field reporter), streaming via Fubo
Weather Forecast (New Orleans, LA)
Kickoff Temp: ~88°F (31°C) outside
Conditions: Hot, humid, partly cloudy
Impact: None — game played indoors at the Superdome.
Injury Report
San Francisco 49ers:
TE George Kittle — Out
WR Jauan Jennings — Questionable (ankle)
WR Jordan Watkins — Questionable (hamstring)
RB Jordan James — Questionable (shoulder)
QB Brock Purdy — Questionable (undisclosed)
New Orleans Saints:
DE Chase Young — Questionable (groin)
OT Trevor Penning — Questionable (ankle)
S Jordan Howden — Questionable (hamstring)
S Julian Blackmon — Questionable (shoulder)
OT Taliese Guaga — Questionable (knee)
Recent Form
49ers: W-L-L-L-W — Defense holding opponents under 20 points in 3 of last 5.
Saints: L-W-L-L-L — Offense averaging just 15.6 PPG in that span.
Series History
All-Time: 49ers lead 50–27–2
Last Meeting: Nov. 27, 2022 — 49ers won 13-0 in Santa Clara
Trend: San Francisco has won 6 of last 9 meetings; Saints last home win vs. SF was in 2014.
Key Player Matchups
QB Battle:
Brock Purdy (SF) — Questionable, but if active, brings efficiency and timing-based passing.
Spencer Rattler (NO) — 27/46, 214 YDS in Week 1; needs to improve red-zone execution.
Skill Positions:
SF RB Christian McCaffrey vs. NO front seven — CMC had 95 total yards in Week 1; Saints allowed just 3.4 YPC vs. ARI.
NO RB Alvin Kamara vs. SF linebackers — Kamara scored Saints’ only TD in Week 1, but totaled just 57 yards.
Defensive Spotlight:
Nick Bosa (SF) vs. Trevor Penning (NO) — elite pass rusher against a tackle nursing an ankle injury.
Betting Trends
49ers are 6-2-1 ATS in last 9 vs. Saints
49ers are 1-5 ATS in last 6 road games
Saints are 4-10 ATS in last 14 overall
Under is 6-1 in Saints’ last 7 games
49ERS NOTES:
• QB BROCK PURDY passed for 277 yards & 2 TDs in Week 1. Aims for his 4th in row with 275+ pass yards & 2+ TD passes. Needs 205 pass yards to reach 10,000 career pass yards. • QB MAC JONES can make SF debut. Has 10,590 pass yards & 54 TD passes in 52 games (49 starts) with NE (2021-23) & Jax. (2024). • RB CHRISTIAN MCCAFFREY had 9 receptions & 142 scrimmage yards (73 rec., 69 rush) in Week 1, his 31st career game with 50+ rush yards & 50+ rec. yards, 2nd-most in NFL history. Has 24 career games with 150+ scrimmage yards, 2nd-most in NFL since 2017. Has 50 catches (5.6 per game), 858 scrimmage yards (95.3 per game) & 5 TDs (3 rush, 2 rec.) in 9 career games vs. NO. Has 50+ scrimmage yards in 27 straight games, 2nd-longest active streak in NFL. • RB BRIAN ROBINSON had 87 scrimmage yards (65 rush, 22 rec.) in his only career game at NO (12/15/24 w/ Was.). • WR RICKY PEARSALL led team with 108 rec. yards in Week 1, his 2nd-career 100-yard game. Aims for his 4th in row with 65+ rec. yards. • WR JAUAN JENNINGS had 6 catches for 49 yards & rec. TD in last meeting. • TE JAKE TONGES had GW rec. TD in Week 1, his 1st-career TD catch. • LB FRED WARNER led team with 8 tackles & had TFL in Week 1. Aims for his 4th in row with TFL. Had 2 PD & FF in last meeting. • LB DEE WINTERS had 1st 2 career TFL last week. Aims for his 5th in row with 6+ tackles. • DL NICK BOSA had 3 TFL, sack, FF & FR last week, his 8th-career game with 3+ TFL. Has 22 games with 2+ TFL since 2019, 3rd-most in NFL. Had sack in last meeting & aims for his 3rd in row vs. NO with TFL. • DL SAM OKUAYINONU had 2nd-career FF last week. • CB RENARDO GREEN had PD last week & aims for his 5th in row with PD. • S MARQUES SIGLE (rookie) had 1st-career FR last week in NFL debut.
SAINTS NOTES:
• QB SPENCER RATTLER had career highs in completions (27) & atts. (46) in Week 1, tied-most pass atts. in NFL last week. Has 20+ completions in each of his 4 career home starts. • RB ALVIN KAMARA had 57 scrimmage yards (45 rush, 12 rec.) & 61st-career rush TD in Week 1. Aims for his 9th in row with 50+ scrimmage yards. Is 1 of 3 all-time (HOFers Marshall Faulk & Lenny Moore) with 60+ rush TDs & 25+ rec. TDs (25). Had 7 catches, 98 scrimmage yards (83 rec., 15 rush) & 3 TDs (2 rush, 1 rec.) in last home meeting (11/15/20). Is 1 of 4 active players (Saquon Barkley, Christian McCaffrey & Jonathan Taylor) with career average of 100+ scrimmage yards per game. • WR CHRIS OLAVE had 7 catches for 54 yards last week, his 11th-career game with 7+ receptions. Had 5 catches for 62 yards in last meeting. • WR RASHID SHAHEED had 6 catches last week, his 3rd-career game with 6+ receptions. • TE JUWAN JOHNSON led all TEs in receptions (career-high tying 8) & had tied 3rd-most rec. yards (76) among TEs in Week 1. Aims for his 4th in row with 6+ receptions & 65+ rec. yards. • DE CAMERON JORDAN had 1.5 sacks last week & has 123 career sacks, 2ndmost among active players. Aims for his 6th in row with TFL. • DE CARL GRANDERSON had 1.5 sacks & 2nd-career game with 2 PD last week. • LB DEMARIO DAVIS had 9 tackles & 2 TFL last week. Has 6 TFL in his past 5. Aims for his 7th in row with 8+ tackles. • LB PETE WERNER had 9 tackles & 1st-career full sack last week. Has 5+ tackles in each of his past 13 games. • CB ALONTAE TAYLOR had 6th-career sack last week. • CB KOOL-AID MCKINSTRY had career-high 7 tackles last week. • S JULIAN BLACKMON had 7 tackles & PD in NO debut last week.
Game Odds
San Francisco 49ers – 6.5
New Orleans Saints 43.5
Odds Courtesy of Sports Odd Direct as of Saturday, September 13, 2025
