MLB Game Preview: Houston Astros (78-66) vs. Toronto Blue Jays (82-61)

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Toronto Blue Jays logo

First Pitch: 7:07 PM ET
Venue: Rogers Centre, One Blue Jays Way, Toronto, Ontario, Canada
Capacity: ~49,000 (retractable roof)
Coverage: Sportsnet (Canada), Space City Home Network (Houston), MLB.TV, Sportsnet Radio Network, KBME 790 AM (Houston)

Weather Forecast (Toronto, ON)

  • Conditions: Mostly sunny outside; roof likely closed for climate control
  • Outside Temperature: ~72°F (22°C)
  • Wind: 5–7 mph from the southwest
  • Precipitation Chance: <10%
  • Impact: Minimal — controlled indoor environment

Injury Report

Toronto Blue Jays

  • Robinson Pina (Elbow), Nick Sandlin (Elbow), Yimi Garcia (Ankle), Bowden Francis (Shoulder), Ryan Burr (Shoulder), Anthony Santander (Shoulder), Alek Manoah (Elbow), Angel Bastardo (Elbow) — all on 60-day IL

Houston Astros

  • Kaleb Ort (Elbow), Spencer Arrighetti (Elbow), John Rooney (Concussion/Nasal), Brendan Rodgers (Oblique), Pedro Leon (Knee), Brandon Walter (Elbow), Bennett Sousa (Elbow), Josh Hader (Shoulder), Isaac Paredes (Hamstring), Zach Dezenzo (Hand), Ronel Blanco (Elbow), Hayden Wesneski (Elbow) — various IL stints

Recent Form

Blue Jays (Last 10): 5–5 (.285 AVG, 4.65 ERA, +6 run diff)
Astros (Last 10): 4–6 (.246 AVG, 3.76 ERA, even run diff)

Series History

  • Season Series: Toronto leads 2–1
  • Trend: Blue Jays thrive at home (67–26 when recording 8+ hits); Astros dangerous when hitting 2+ HR (36–7 in such games)

Key Player Matchups

  • Vladimir Guerrero Jr. (TOR) — .301 AVG, 33 2B, 23 HR, 79 RBI — vs. Luis Garcia (HOU) — 1–0, 4.50 ERA, 0.50 WHIP
  • George Springer (TOR) — 11-for-36 last 10 games, 2 2B, 3 HR — vs. Astros bullpen (3.76 ERA last 10)
  • Jose Altuve (HOU) — 24 HR, .442 SLG — vs. Jose Berríos (TOR) — 9–5, 4.02 ERA, 1.29 WHIP
  • Yordan Alvarez (HOU) — 16-for-36 last 10 games, 2 2B, 2 HR, 7 RBI

Betting Trends

  • Blue Jays are 19–5 when favored at -160 or shorter
  • Astros are 6–2 as underdogs of +134 or longer
  • Over is 6-4 in Toronto’s last 10 games
  • Astros have won 28 of 49 games as underdogs this season

Game Odds

Houston Astros                 8.5

Toronto Blue Jays             – 160

Odds Courtesy of Sports Odds Direct as of Monday, September 8, 2025