MLB Game Preview: Pittsburgh Pirates (64-80) vs. Baltimore Orioles (66-77)

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Baltimore Orioles logo

First Pitch: 6:35 PM ET
Venue: Oriole Park at Camden Yards, 333 West Camden Street, Baltimore, MD 21201
Capacity: ~45,000
Coverage: MASN (Orioles), SportsNet Pittsburgh, KDKA AM/FM, MLB.TV

Weather Forecast (Baltimore, MD)

  • Conditions: Mostly sunny
  • First Pitch Temperature: ~78°F (26°C)
  • Wind: 6 mph from the southwest
  • Precipitation Chance: <5%
  • Impact: Ideal baseball weather — minimal effect on ball flight or pitching grip

Injury Report

Baltimore Orioles

  • Samuel Basallo (Hand) – Day-to-day
  • Dean Kremer (Forearm) – Day-to-day
  • Jordan Westburg (Ankle) – 10-day IL
  • Adley Rutschman (Oblique) – 10-day IL
  • Felix Bautista (Shoulder), Zach Eflin (Back), Grayson Rodriguez (Elbow) – 60-day IL
  • Tyler O’Neill (Wrist) – 10-day IL
  • Multiple long-term IL stints affecting bullpen depth

Pittsburgh Pirates

  • Ronny Simon (Shoulder) – 10-day IL
  • Jack Suwinski (Groin) – 10-day IL
  • Endy Rodriguez (Elbow), Jared Jones (Elbow) – 60-day IL
  • Enmanuel Valdez (Shoulder) – 60-day IL

Recent Form

Orioles (Last 10): 6–4 (.249 AVG, 4.40 ERA, -3 run diff)
Pirates (Last 10): 5–5 (.227 AVG, 3.68 ERA, -4 run diff)

Series History

  • 2025 Season: First meeting between these clubs
  • Last Meeting: 2023 — Orioles took 2 of 3 in Pittsburgh
  • Trend: Interleague matchups between these two are rare; no postseason history

Key Player Matchups

  • Gunnar Henderson (BAL) — .274 AVG, 16 HR, 61 RBI — vs. Mike Burrows (PIT) — 4.08 ERA, 1.26 WHIP
  • Ryan Mountcastle (BAL) — Hot bat: 12-for-42 last 10 games — vs. Pirates’ bullpen (3.68 ERA last 10)
  • Oneil Cruz (PIT) — 19 HR, 56 RBI — vs. Kyle Bradish (BAL) — 3.60 ERA, 1.00 WHIP

Betting Trends

  • Orioles are 5-5 when favored at -158 or shorter this season
  • Pirates are 17-31 as underdogs of +132 or longer
  • The Under is 6-4 in Orioles’ last 10 games
  • Pirates are 41-25 when not allowing a home run

Game Odds

Pittsburgh Pirates            8.5

Baltimore Orioles            – 158

Odds Courtesy of Sports Odds Direct as of Monday, September 8, 2025